Clear Cell Sarcoma of Tendons and Aponeuroses

Malignant Melanoma of Soft Tissues
  • Mario Campanacci


This highly malignant tumor seems to be of neuroectodermal origin, possibly from melanocytes migrated during the embryonic development. Cytogenetically, a translocation of chromosomes 12 and 22 (which is not a feature of melanomas) has been frequently found.


Soft Tissue Tumor Malignant Peripheral Nerve Sheath Tumor Melanin Pigment Acta Pathol Clear Cytoplasm 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Enzinger F.M. 1965: Clear-cell sarcoma of tendons and aponeuroses. An analysis of 21 cases. Cancer, 18, 1163–1174.PubMedCrossRefGoogle Scholar
  2. Angervall L., Stener B. 1969: Clear-cell sarcoma of tendons. A study of four cases. Acta Pathol. Microbiol. Scand., 77, 589–597.PubMedCrossRefGoogle Scholar
  3. Dutra F.R. 1970: Clear cell sarcoma of tendons and aponeuroses. Three additional cases. Cancer, 25, 942–946.PubMedCrossRefGoogle Scholar
  4. Hoffman G.J., Carter D. 1973: Clear cell sarcoma of tendons and aponeuroses with melanin. Arch. Pathol., 95, 22–25.PubMedGoogle Scholar
  5. Mackenzie D.H. 1974: Clear cell sarcoma of tendon and aponeuroses with melanin production. J. Pathol., 114, 231–232.PubMedCrossRefGoogle Scholar
  6. Bearman R.M., Noe J., Kempson R. 1975: Clear cell sarcoma with melanin pigment. Cancer, 36, 977–984.PubMedCrossRefGoogle Scholar
  7. Alitalo K., Paavolainen P., Franssila K., Ritsila V. 1977: Clear-cell sarcoma of tendons and aponeuroses. Report of two cases. Acta Orthop. Scand., 48, 241–244.PubMedCrossRefGoogle Scholar
  8. Haydu S.I., Shiu M.H., Fortner J.G. 1977: Tendosynovial sarcoma. A clinicopathologic study of 136 cases. Cancer, 39, 1201–1217.CrossRefGoogle Scholar
  9. Boudreaux D., Waisman J. 1978: Clear cell sarcoma with melanogenesis. Cancer, 41, 1387–1394.PubMedCrossRefGoogle Scholar
  10. Chung E.B., Enzinger F.M. 1978: Clear cell sarcoma of tendons and aponeuroses. Further observations, abstracted. Lab. Invest., 38, 338.Google Scholar
  11. Toe T.K., Saw D. 1978: Clear cell sarcoma with melanin. Report of two cases. Cancer, 41, 235–238.PubMedCrossRefGoogle Scholar
  12. Tsuneyoshi M., Enjoji M., Kubo T. 1978: Clear cell sarcoma of tendons and aponeuroses. A comparative study of 13 cases with provisional subgrouping into the melanotic and synovial types. Cancer, 42, 243–252.PubMedCrossRefGoogle Scholar
  13. Ekfors T.O., Rantakokko V. 1979: Clear cell sarcoma of tendons and aponeuroses: malignant melanoma of soft tissue. Report of four cases. Pathol. Res. Pract., 165, 422–428.PubMedCrossRefGoogle Scholar
  14. Radstone D.J., Revell P.A., Mantell B.S. 1979: Clear cell sarcoma of tendons and aponeuroses treated with bleomycin and vincristine. Br. J. Radiol., 52, 238–241.PubMedCrossRefGoogle Scholar
  15. Raynor A.C., Vargas-Cortes F., Alexander R.W., Bingham H.G. 1979: Clear-cell sarcoma with melanin pigment: a possible soft-tissue variant of malignant melanoma. Case report. J. Bone Joint. Surg., 61-A, 276–280.Google Scholar
  16. Parker J.B., Marcus P.B., Martin J.H. 1980: Spinal melanotic clear-cell sarcoma: a light and electron microscopic study. Cancer, 46, 718–724.PubMedCrossRefGoogle Scholar
  17. Eckardt J.J., Pritchard D.J., Soule E.H. 1983: Clear cell sarcoma. A clinicopathologic study of 27 cases. Cancer, 52, 1482–1488.PubMedCrossRefGoogle Scholar
  18. Kindblom L.G., Lodding P., Angervall L. 1983: Clear-cell sarcoma of tendons and aponeuroses. An immunohistochemical and electron microscopic analysis indicating neural crest origin. Virchows Arch., 401, 109–128.CrossRefGoogle Scholar
  19. Katenkamp D., Perevoshchikov A.G., Raikhlin N.T. 1984: Soft tissue clear cell sarcoma. Morphology, differential diagnosis and tumor classification. Zentralbl. Allg. Pathol., 129, 521–531.PubMedGoogle Scholar
  20. Ben-Romdhane B.K., Lacombe M.J., Sevin D., Bertin F., Boddaert A., Caillou B., Contesso G. 1984: Les sarcomes a cellules claires des tissus mous. Reevaluation des sarcomes a cellules claires des tendons et de gaines. A propos de 14 cas. Ann. Pathol., 4, 349–360.PubMedGoogle Scholar
  21. Benson J.D., Kraemer B.B., Mackay B. 1985: Malignant melanoma of soft parts. An ultrastructural study of four cases. Ultrastruct. Pathol., 8, 57–70.PubMedCrossRefGoogle Scholar
  22. Hasegawa T., Hirose T., Kudo E., Hizawa R. 1989: Clear-cell sarcoma. An immunohistochemical and ultra-structural study. Acta Pathol. Jpn., 39, 321–327.PubMedGoogle Scholar
  23. Swanson P.E., Wick M.R. 1989: Clear-cell sarcoma: an immunohistochemical analysis of six case and comparison with other epithelioid neoplasms of soft tissue. Acta Pathol. Lab. Med., 113, 55–60.Google Scholar
  24. Lucas D.R., Nascimento A.G., Sim F.H. 1992: Clear cell sarcoma of soft tissues. Mayo Clinic experience with 35 cases. Am. J. Surg. Pathol., 16, 119–1204.CrossRefGoogle Scholar
  25. Stenman G., Kindblom L.G., Angervall L. 1992: Reciprocal translocation t(12; 22)(q13; q13) in clear-cell sarcoma of tendons and aponeuroses. Genes. Chromosom. Cancer, 4, 122–127.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Wien 1999

Authors and Affiliations

  • Mario Campanacci
    • 1
    • 2
  1. 1.University of BolognaItaly
  2. 2.Rizzoli Orthopaedic InstituteBolognaItaly

Personalised recommendations