Malignant Peripheral Nerve Sheath Tumor (MPNST)

  • Mario Campanacci


This usually high-grade sarcoma mainly consists of spindle cells of both schwannian and fibroblastic type, and occasionally may have focal heterogeneous differentiation, such as chondroid, osteoid, rhabdomyoblastic, epithelial, endothelial, and melanocytic. This histology recapitulates the components of the nerve sheath (Schwann cells and fibroblasts), but also the potential differentiation of the primitive neural crest (schwannian, mesenchymal, primitive neuroblastic, epithelial, melanocytic: see pag. 11).


Spindle Cell Synovial Sarcoma Soft Tissue Tumor Malignant Peripheral Nerve Sheath Tumor Small Round Cell 
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Copyright information

© Springer-Verlag Wien 1999

Authors and Affiliations

  • Mario Campanacci
    • 1
    • 2
  1. 1.University of BolognaItaly
  2. 2.Rizzoli Orthopaedic InstituteBolognaItaly

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