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Malignant Fibrous Histiocytoma

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Bone and Soft Tissue Tumors

Abstract

It is a high-grade pleomorphic sarcoma, whose mesenchymal cells are poorly differentiated. Some are recognizable as fibroblasts, others present histiocyte-like features although they are not true histiocytes.

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References

  • Ozzello L., Stout A.P., Murray M.R.: Cultural characteristics of malignant histiocytomas and fibrous xanthomas. Cancer, 16, 331–344. 1963

    Article  PubMed  CAS  Google Scholar 

  • Guccion J.G., Enzinger F.M.: Malignant giant cell tumor of soft parts. An analysis of 32 cases. Cancer, 29, 1518–1529. 1972

    Article  PubMed  CAS  Google Scholar 

  • Kempson R.L., Kyriakos M.: Fibroxanthosarcoma of the soft tissues. A type of malignant fibrous histiocytoma. Cancer, 29, 961–976. 1972

    Article  PubMed  CAS  Google Scholar 

  • Soule E.H., Enriquez P.: Atypical fibrous histiocytoma, malignant fibrous histiocytoma, malignant histiocytoma and epithelioid sarcoma. Cancer, 30, 128–143. 1972

    Article  PubMed  CAS  Google Scholar 

  • Fu Y.S, Gabbiani G., Kaye G.I., LattesR.: Malignant soft tissue tumors of probable histiocytic origin (malignant fibrous histiocytomas): general considerations and electron microscopic and tissue culture studies. Cancer, 35, 176–198. 1975

    Article  PubMed  CAS  Google Scholar 

  • Kyriakos M., Kempson R.L.: Infiammatory fibrous histiocytoma: an aggressive and lethal lesion. Cancer, 37, 1584–1606.19761976 INADA O., YUMOTO T., FURUSE K., TANAKA T.: Ultrastructural features of malignant fibrous histiocytoma of bone. Acta Pathol. Jpn., 26, 491–501.

    Google Scholar 

  • Alguacil-Garcia A., Unni K.K., Goellner J.R.: Malignant giant cell tumor of soft parts: an ultrastructural study of four cases. Cancer, 40, 244–253. 1977

    Article  PubMed  CAS  Google Scholar 

  • TaxyJ.B., BattiforaH.: Malignant fibrous histiocytoma: an electronic microscopy study. Cancer, 40, 254–267. 1977

    Article  PubMed  CAS  Google Scholar 

  • WeissS.W., EnzingerF.M.: Myxoid variant of malignant fibrous histiocytoma. Cancer, 39, 1672–1685. 1978

    Article  Google Scholar 

  • Alguacil-GarciaA., UnniK.K., Goellner J.R.: Malignant fibrous histiocytoma: an ultrastructural study of six cases. Am. J. Clin. Pathol., 69, 121–129. 1977

    Google Scholar 

  • WeissS.W., EnzingerF.M.: Malignant fibrous histiocytoma: an analysis of 200 cases. Cancer, 41, 2250–2266. 1978

    Article  PubMed  CAS  Google Scholar 

  • LagaceR., DelageC., SeemayerT.A.: Myxoid variant of malignant fibrous histiocytoma: ultrastructural observations. Cancer,43 526–534.19791980

    Google Scholar 

  • Enjoji M., Hashimoto H., Tsuneyoshi M., Iwasaki H.: Malignant fibrous histiocytoma: a clinicopathologic study of 130 cases. Acta Pathol. Jpn., 30, 727–741. 1980

    PubMed  CAS  Google Scholar 

  • Kearney M.M., Soule E.H., Ivins J.C.: Malignant fibrous histiocytoma: a retrospective study of 167 cases. Cancer, 45, 167–178. 1980

    Article  PubMed  CAS  Google Scholar 

  • Meister P., Nathrath W.: Immunohistochemical markers of histiocytic tumors. Hum. Pathol., 11, 300301. 1980

    Google Scholar 

  • Du Boulay C.E.H.: Demonstration of alpha-l-antitrypsin and alpha-1-antichymotrypsin in fibrous histiocytomas using immunoperoxidase technique. Am. J. Surg. Pathol., 6, 559–564. 1982

    Article  PubMed  Google Scholar 

  • Magnusson B., Kindblom L.G., Angervall L.: Enzyme histochemistry of malignant fibroblastic histiocytic tumors. A light and electron microscopic analysis. Appl. Pathol., 1, 223–240. 1983

    PubMed  CAS  Google Scholar 

  • Fletcher C.D., Mckee P.H.: Sarcomas: a clinicopathological guide with particular references to cutaneous manifestation. I. Dermatofibrosarcoma protuberans, malignant fibrous histiocytoma and the epithelioid sarcoma of Enzinger. Clin. Exp. Dermatol., 9, 451–465. 1984

    Article  PubMed  CAS  Google Scholar 

  • Tracy T. Jr., Neifeld J.P., Demay R.M., Salzberg A.M.: Malignant fibrous histiocytomas in children. J. Pediatr. Surg., 19, 81–83. 1984

    Article  PubMed  Google Scholar 

  • Weiss L.M., Warhol M.J.: Ultrastructural distinctions between adult pleomorphic rhabdomyosarcomas, pleomorphic liposarcomas, and pleomorphic malignant fibrous histiocytomas. Hum. Pathol., 15, 1025 1033. 1984

    Google Scholar 

  • Fischer H.J., Lois J.F., Gomes A.S., Mirra J.M., Deutsch L.S.: Radiology and pathology of malignant fibrous histiocytomas of the soft tissue: a report of ten cases. Skeletal Radiol., 13, 202–206. 1985

    Article  PubMed  CAS  Google Scholar 

  • Brecher M.E., Franklin W.A.: Absence of mononuclear phagocyte antigens in malignant fibrous histiocytoma. Am. J. Clin. Pathol., 86, 344–348. 1986

    PubMed  CAS  Google Scholar 

  • Lawson C.W., Fisher C., Gatter K.C.: An immunohistochemical study of differentiation in malignant fibrous histiocytoma. Histopathology, 11, 375–383. 1987

    Article  PubMed  CAS  Google Scholar 

  • Miettinen M., Soini Y.: Malignant fibrous histiocytoma: heterogeneous patterns of intermediate filament proteins by immunohistochemistry. Arch. Pathol. Lab. Med., 113, 1363–1366. 1989

    PubMed  CAS  Google Scholar 

  • Fisher C.: The value of electronmicroscopy and immunohistochemistry in the diagnosis of soft tissue sarcomas: a study of 200 cases. Histopathology, 16, 441–454. 1990

    Article  PubMed  CAS  Google Scholar 

  • Wolf H.K., Harrelson J.M., BOSSEN E.H.: Multicentric malignant fibrous histiocytoma of soft tissue. Am. J. Surg. Pathol., 14, 188–193. 1990

    Article  PubMed  CAS  Google Scholar 

  • Rooser B., Willen H., Gustafson P., Alvegard T.A., Rydholm A.: Malignant fibrous histiocytoma of soft tissue. A population-based epidemiologic and prognostic study of 137 patients. Cancer, 67, 499505. 1991

    Google Scholar 

  • Rydholm A., Gustafson P., Rooser B., Willen H., Berg N.O.: Subcutaneous sarcoma. A population-based study of 129 patients. J. Bone Joint Surg.,73-B, 662–667. 1991

    Google Scholar 

  • Wiklund T.A., Blomqvist C.P., Raty J., Elomaa I., Rissanen P., Miettinen M.: Postirradiation sarcoma. Analysis of a nationwide cancer registry material. Cancer, 68, 524–531. 1991

    Article  PubMed  CAS  Google Scholar 

  • Brady M.S., Gaynor J.J., Brennan M.F.: Radiation-associated sarcoma of bone and soft tissue. Arch. Surg., 127, 1379–1385. 1992

    Article  PubMed  CAS  Google Scholar 

  • Fletcher C.D.: Pleomorphic malignant fibrous histiocytoma: fact or fiction? A critical reappraisal based on 159 tumors diagnosed as pleomorphic sarcoma. Am. J. Surg. Pathol. 16, 213–228. 1992

    Article  PubMed  CAS  Google Scholar 

  • Iwasaki H., Isayama T., Ohjimi Y., Kikuchi M., Yoh S., Shinohara N., Yoshitake K., Ishiguro M., Kamada N., Enjoji M.: Malignant fibrous histiocytoma. A tumor of facultative histiocytes showing mesenchymal differentiation in cultured cell lines. Cancer, 69, 437–447. 1992

    Article  PubMed  CAS  Google Scholar 

  • Pezzi C.M., Rawlings M.S. Jr., Esgro J.J., Pollock R.E., Romsdahl M.M.: Prognostic factors in 227 patients with malignant fibrous histiocytoma. Cancer, 69, 2098–2103. 1992

    Article  PubMed  CAS  Google Scholar 

  • Hollowood K., Fletcher C.D.: Malignant fibrous histiocytoma: morphologic pattern or pathologic entity? Semin. Diagn. Pathol., 12, 210–220. 1995

    PubMed  CAS  Google Scholar 

  • Meister P.: Malignant fibrous histiocytoma: histomorphological pattern or tumor type? Pathol. Res. Pract., 192, 877–881. 1996

    Article  PubMed  CAS  Google Scholar 

  • Walter T.A., Weh H.J., Schlag P.M., Zornig C., Hossfeld D.K.: Cytogenetic studies in malignant fibrous histiocytoma. Cancer Genet. Cytogenet., 94, 131–134. 1997

    Article  PubMed  CAS  Google Scholar 

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© 1999 Springer-Verlag Wien

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Campanacci, M. (1999). Malignant Fibrous Histiocytoma. In: Bone and Soft Tissue Tumors. Springer, Vienna. https://doi.org/10.1007/978-3-7091-3846-5_67

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  • DOI: https://doi.org/10.1007/978-3-7091-3846-5_67

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-3848-9

  • Online ISBN: 978-3-7091-3846-5

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