Massive Idiopathic Osteolysis

massive osteolysis due to hemangiomatosis, disappearing — phantom-vanishing bone, Ghoram-Stout’s disease
  • Mario Campanacci


Massive osteolysis is a cryptogenetic, non neoplastic, self limited disease characterized by progressive dissolution of the affected bone(s), associated with vascular dilatation and hyperplasia, and resulting in fibrous substitution of the affected tissues (bone, muscle).


Surrounding Soft Tissue Prosthetic Replacement Massive Osteolysis Progressive Dissolution Pelvic Osteolysis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1955.
    Gorham L.W., Stout A.P.: Massive osteolysis (acute spontaneous absorption of bone, phantom bone, disappearing bone). Its relation to hemangiomatosis. J. Bone Joint Surg., 37-A, 985–1004.PubMedGoogle Scholar
  2. 1958.
    Hambach R., Pujman J., Maly V.: Massive osteolysis due to hemangiomatosis. Report of a case of Gorham’s disease with autopsy. Radiology, 71, 43–47.PubMedGoogle Scholar
  3. 1958.
    Johnson P.M., McClure J.G.: Observations on massive osteolysis. A review of the literature and report of a case. Radiology, 71, 28–42.PubMedGoogle Scholar
  4. 1964.
    Halliday D.R., Dahlin D.C., Pugh D.G., Young H.H.: Massive osteolysis and angiomatosis. Radiology, 82, 637–644.PubMedGoogle Scholar
  5. 1967.
    Baciu C.L., Temelie A, Roventza N., Filipesco G.: Osteolyse essentielle massive du bassin. Acta Orthop. Belg., 33, 788–796.Google Scholar
  6. 1967.
    Stern M. B., Goldman R. L.: Disappearing bone disease. Report of a case and review of the literature. Clin. Orthop., 53, 99–107.PubMedGoogle Scholar
  7. 1968.
    Poirier H.: Massive osteolysis of the humerus treated by resection and prosthetic replacement. J. Bone Joint Surg., 50-B, 158–160 1968.Google Scholar
  8. 1968.
    Tilling G., Skobowytsh B.: Disappearing bone disease, morbus Gorham. Report of a case. Acta Orthop. Scand., 39, 398–406.PubMedCrossRefGoogle Scholar
  9. 1969.
    Torg J.S., Steel H.H.: Sequential roentgenographic changes occurring in massive osteolysis. J. Bone Joint Surg., 51-A, 1649–1655.Google Scholar
  10. 1970.
    Kery L., Wouters H.W.: Massive osteolysis. Report of two cases. J. Bone Joint Surg., 52-B, 452–459.Google Scholar
  11. 1974.
    Imbert J.C., Picault C.: Osteolyse massive idiopathique ou maladie de Jackson-Gorham. Rev. Chir. Orthop., 60, 73–80.PubMedGoogle Scholar
  12. 1974.
    Sage R.M., Allen P.W.: Massive osteolysis. Report of a case. J. Bone Joint Surg., 56-B, 130–135.Google Scholar
  13. 1974.
    Thompson J.S., Schurman D.J.: Massive osteolysis. Case report and review of the literature. Clin. Orthop., 103, 206–211.PubMedCrossRefGoogle Scholar
  14. 1976.
    Patrick J.H.: Massive osteolysis complicated by chylothorax successfully treated by pleurodesis. J. Bone Joint Surg., 58-B, 347–349.Google Scholar
  15. 1977.
    Heyden G., Kindblom L.G., Nielsen J.M.: Disappearing bone disease J. Bone Joint Surg., 59-A, 57–61.Google Scholar
  16. 1977.
    Sacristan H.D., Ferrandez Portal L., Casiresana Gomez F., Rodriguez P.: Massive osteolysis of the scapula and ribs. J. Bone Joint Surg., 59-A, 405–406.Google Scholar
  17. 1983.
    Edwards W.H., Thompson R.C., Varsa E.W.: Lymphangiomatosis and massive osteolysis of the cervical spine. A case report and review of the literature. Clin. Orthop., 177, 222–229.PubMedGoogle Scholar
  18. 1983.
    Gherlinzoni F., Rocco M.: Progressive telangiectatic osteolysis. Ital. J. Orthop. Traumatol., 9, 515–519.PubMedGoogle Scholar
  19. 1987.
    Hejgaard N., Olsen P.R.: Massive Gorham osteolysis of the right hemipelvis complicated by chylothorax: report of a case in a 9-year-old boy successfully treated by pleurodesis. J. Pediatr. Orthop., 7, 96–99.PubMedCrossRefGoogle Scholar
  20. 1987.
    Joseph J., Bartal E.: Disappearing bone disease: a case report and review of the literature. J. Pediatr. Orthop., 7, 584–588.PubMedCrossRefGoogle Scholar
  21. 1989.
    Mendez A.A., Keret D., Robertson W., MacEwen G.D.: Massive osteolysis of the femur (Gorham’s disease): a case report and review of the literature. J. Pediatr. Orthop., 9, 604–608.PubMedCrossRefGoogle Scholar
  22. 1990.
    Kulenkampff H.A., Richter G.M., Hasse W.E., Adler C.P.: Massive pelvic osteolysis in the Gorham-Stout syndrome. Int. Orthop., 14, 361–366.PubMedCrossRefGoogle Scholar
  23. 1990.
    Turra S., Gigante C., Scapinelli R.: A 20-year follow-up study of a case of surgically treated massive osteolysis. Clin. Orthop., 250, 297–302.PubMedGoogle Scholar
  24. 1991.
    Friedman L., Horwitz T., Beck M., Sinn R.: Case report 672. Gorham’s disease. Skeletal Radiol., 20, 307–309.PubMedCrossRefGoogle Scholar
  25. 1993.
    Dunbar S.F., Rosenberg A., Mankin H., Rosenthal D., Suit H.D.: Gorham’s massive osteolysis: the role of radiation therapy and a review of the literature. Int. J. Radiat. Oncol. Biol. Phys., 26, 491–497.PubMedCrossRefGoogle Scholar
  26. 1994.
    Drewry G.R., Sutterlin C.E.3rd., Martinez C.R., Brantley S.G.: Gorham disease of the spine. Spine, 19, 2213–2222.PubMedCrossRefGoogle Scholar
  27. 1994.
    Vinee P., Tanyu M.O., Hauenstein K.H., Sigmund G., Stover B., Adler C.P.: CT and MRI of Gorham syndrome. J. Comput. Assist. Tomogr., 18, 985–989.PubMedCrossRefGoogle Scholar
  28. Devlin R.D., Bone H.G. 3rd. Roodman G.D.: Interleukin-6: a potential mediator of the massive osteolysis in patients with Gorham-Stout disease. J. Clin. Endocrinol. Metab.,81 1893–1897 1996.Google Scholar
  29. 1997.
    Spieth M.E., Greenspan A., Forrester D.F., Ansari A.N., Kimura R.L., Gleason-Jordan I.: Gor-ham’s disease of the radius: radiographic, scintigraphic, and MRI findings with pathologic correlation. Skeletal Radiol., 26, 659–663.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Wien 1999

Authors and Affiliations

  • Mario Campanacci
    • 1
    • 2
  1. 1.University of BolognaItaly
  2. 2.Rizzoli Orthopaedic InstituteBolognaItaly

Personalised recommendations