Skip to main content

Metastatic Bone Disease

  • Chapter
Bone and Soft Tissue Tumors

Abstract

The vast majority of metastases to bones are due to visceral carcinomas. Any malignant tumor, however, can metastasize to the skeleton, namely sarcomas (of bone, soft tissue, or viscera), melanomas, and neuroblastomas.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 74.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

Metastatic bone disease

  1. Abrams H.L., Spiro R., Goldestein N. 1950: Metastases in carcinoma. Analysis of 1000 autopsied cases. Cancer, 3, 76–85.

    Article  Google Scholar 

  2. Young J.M., Funk F.J. Jr. 1954: Incidence of tumor metastasis to the lumbar spine. A comparative study of roentgenographic changes and gross lesions. J. Bone Joint Surg., 35-A, 55–64.

    Google Scholar 

  3. Sum P. W., Roswii B., Unger S.M. 1960: Skeletal metastases from malignant testicular tumors. A report of 10 cases with osteolytic and osteoblastic changes. Am. J. Roentgenol., 83, 704–708.

    CAS  Google Scholar 

  4. Toomey F.B., Felson B. 1960: Osteoblastic bone metastasis in gastrointestinal and bronchial carcinoids. Am. J. Roentgenol., 83, 709–715.

    CAS  Google Scholar 

  5. McCoRmacx K.B. 1966: Bone metastases from thyroid carcinoma. Cancer, 19, 181–184.

    Article  Google Scholar 

  6. Norman A., Leventhal E. 1966: Skeletal metastases from latent primary carcinomas of gastrointestinal tract. N.Y. State J. Med., 66, 2814–2817.

    PubMed  CAS  Google Scholar 

  7. Briggs R.C. 1967: Detection of osseous metastases. Evaluation of bone scanning with strontium-85. Cancer, 20, 392–395.

    Article  PubMed  CAS  Google Scholar 

  8. Marcove R.C., Yang D.J. 1967: Survival times after treatment of pathologic fractures. Cancer, 20, 2154–2158.

    Article  PubMed  CAS  Google Scholar 

  9. Barer M., Peterson L.F.A., Dahlin D.C., Winkelmann R.K., Stewart J.R. 1968: Mastocytosis with osseous lesions resembling metastatic malignant lesions in bone. J. Bone Joint Surg., 56-A, 142–152.

    Google Scholar 

  10. Legier J.F., Tauber L.N. 1968: Solitary metastasis of occult prostatic carcinoma simulating osteogenic sarcoma. Cancer, 22, 168–172.

    Article  PubMed  CAS  Google Scholar 

  11. RosAI J. 1968: Carcinoma of pancreas simulating giant cell tumor of bone. Electron-microscopic evidence of its acinar cell origin. Cancer, 22, 333–344.

    Article  PubMed  CAS  Google Scholar 

  12. Norman A., Ulin R.A. 1969: A comparative study of periosteal new-bone response in metastatic bone tumors (solitary) and primary bone sarcomas. Radiology, 92, 705–708.

    PubMed  CAS  Google Scholar 

  13. Silverberg S.G., Evans R.H., Koehler A.L. 1969: Clinical and pathologic fractures of initial metastatic presentations of renal cell carcinoma. Cancer, 23, 1126–1132.

    Article  PubMed  CAS  Google Scholar 

  14. Parrish F.F., Murray J. A. 1970: Surgical treatment for secondary neoplastic fractures. A retrospective study of ninety-six patients. J. Bone Joint Surg., 52-A, 665–686.

    Google Scholar 

  15. Beals R.K., Lawton G.D., Snell W.E. 1971: Prophylactic internal fixation of the femur in metastatic breast cancer. Cancer, 28, 1350–1354.

    Article  PubMed  CAS  Google Scholar 

  16. Galasko C.S.B. 1971: Detection of skeletal metastases. J. Bone Joint Surg., 53-B, 153.

    Google Scholar 

  17. White W.A., Patterson R.H. Jr., Bergland R.M. 1971: Role of surgery in the treatment of spinal cord compression by metastatic neoplasm. Cancer, 27, 558–561.

    Article  PubMed  CAS  Google Scholar 

  18. Muggia F.M., Hansen H. H. 1972: Osteoblastic metastases in small-cell (oat-cell) carcinoma of the lung. Cancer, 30, 801–805.

    Article  PubMed  CAS  Google Scholar 

  19. Perez C.A., Bradfield J S, Morgan H.C. 1972: Management et pathological fractures. Cancer, 29, 684–693.

    Article  PubMed  CAS  Google Scholar 

  20. Templeton A.C., Hut’ M.S.R., Dodge O.G. 1972: Cryptogenic metastases in Uganda Africans. J. Bone Joint Surg., 54-B, 125–129.

    Google Scholar 

  21. Duparc J., Nordin J.Y., Olivier H. 1973: Les fractures metastatiques du femur. Rev. Chir. Orthop., 59, 91–108.

    Google Scholar 

  22. Schurman D.J., Amstutz H.C. 1973: Treatment of neoplastic subtrochanteric fracture: six cases treated with the Zickel nail. Clin. Orthop., 97, 108–113.

    Article  PubMed  Google Scholar 

  23. Silverberg S.G., DE Giorgi L.S. 1973: Osteoclastoma like giant-cell tumor of the thyroid. Cancer, 31, 621–625.

    Article  PubMed  CAS  Google Scholar 

  24. Katzner M., Petit R., Schvingt E.: Traitement chirurgical des metastases et des fractures metastatiques des os longs. A propos de 53 osteosyntheses de confort. Rev. Chir. Orthop., 60, 387–400.

    Google Scholar 

  25. Blythe J.G., Cohen M.H., Buchsbaum H.J., Latourette H.B. 1975: Bony metastases from carcinoma of cervix. Occurrence, diagnosis, and treatment. Cancer, 36, 475–484.

    Article  PubMed  CAS  Google Scholar 

  26. Douglass H.O. Jr., Shukla S.K., Mindell E. 1976: Treatment of pathological fractures of long bones excluding those due to breast cancer. J. Bone Joint Surg., 58-A, 1055–1061.

    Google Scholar 

  27. Duparc J., Decoulx J. 1976: Le traitement des metastases osseuses. Masson Ed., Paris.

    Google Scholar 

  28. Zickel R. E., Mouradian W. H. 1976: Intramedullary fixation of pathological fractures and lesions of the subtrochanteric region of the femur. J. Bone Joint Surg., 58-A, 1061–1066.

    Google Scholar 

  29. Oyasu R., Battifora H.A., Buckingham W.B., Hidwegi D. 1977: Metaplastic squamous cell carcinoma of bronchus simulating giant cell tumor of bone. Cancer, 39, 1119–1128.

    Article  PubMed  CAS  Google Scholar 

  30. Deutsch A., Resnick D. 1980: Eccentric cortical metastases to the skeleton from bronchogenic carcinoma. Radiology, 137, 49–52.

    PubMed  CAS  Google Scholar 

  31. Simon M.J., Karluk M.B. 1982: Skeletal metastases of unknown origin. Diagnostic strategy for orthopaedic surgeons. Clin. Orthop., 166, 96–103.

    PubMed  Google Scholar 

  32. Stoll B.A., Parbhoo S. 1983: Bone metastasis: monitoring and treatment. Raven Press, New York. 1986 Galasko C.S.: Skeletal metastases. Butterworths, London.

    Google Scholar 

  33. Simon M.A., Bartucci E.J. 1986: The search for the primary tumor in patients with skeletal metastases of unknown origin. Cancer, 58, 1088–1095.

    Article  PubMed  CAS  Google Scholar 

  34. Bloom R.A., Libson E., Husband J.E., Stoker D.J. 1987: The periosteal sunburst reaction to bone metastases: a literature review and report of 20 additional cases. Skeletal Radiol., 16, 629–634.

    Article  PubMed  CAS  Google Scholar 

  35. Libson E., Bloom R.A., Husband J., Stocker D. 1987: Metastatic tumors of bones of the hand and foot. A comparative review and report of 43 additional cases. Skeletal Radiol., 16, 387–392.

    Article  PubMed  CAS  Google Scholar 

  36. Greenspan A., Norman A. 1988: Osteolytic cortical destruction: an unusual pattern of skeletal metastases. Skeletal Radiol., 17, 402–406.

    Article  PubMed  CAS  Google Scholar 

  37. Harrington K.D. 1988: Anterior decompression and stabilization of the spine as a treatment for vertebral collapse and spinal cord compression for metastatic malignancy. Clin. Orthop., 233, 177–197.

    PubMed  Google Scholar 

  38. Harrington K.D. 1988: Orthopaedic management of metastatic bone disease. Mosby, St. Louis.

    Google Scholar 

  39. Sim F.H. 1988: Diagnosis and management of metastatic bone disease. A multidisciplinary approach. Raven Press, New York.

    Google Scholar 

  40. Gurney H., Larcos G., McKay M., Kefford R., Langlands A. 1989: Bone metastases in hypernephroma. Frequency of scapular involvement. Cancer, 64, 1429–1431.

    CAS  Google Scholar 

  41. Habermann E.T., Lopez R.A. 1989: Metastatic disease of bone and treatment of pathological fractures. Orthop. Clin. North Am., 20, 469–486.

    PubMed  CAS  Google Scholar 

  42. Marcocci C., Pacini F., Elisei R., Schipani E., Ceccarelli C, Miccoli P., Arganini M., Pinchera A. 1989: Clinical and biologic behavior of bone metastases from differentiated tyroid carcinoma. Surgery, 106, 960–966.

    PubMed  CAS  Google Scholar 

  43. Matsuyama T., Tsukamoto N., Imachi M., Nakano H. 1989: Bone mestastasis from cervix cancer. Gynecol. Oncol., 32, 72–75.

    Article  PubMed  CAS  Google Scholar 

  44. Nottebaert M., Exner G.U., Von Hochstetter A.R., Schreiber A. 1989: Metastatic bone disease from occult carcinoma: a profile. Int. Orthop., 13, 119–123.

    Article  PubMed  CAS  Google Scholar 

  45. Talbot R.W., Irvine B., Jass J.R., Dowd G.S., Northover J.M. 1989: Bone metastases in carcinoma of the rectum: a clinical and pathological review. Eur. J. Surg. Oncol., 15, 449–452.

    PubMed  CAS  Google Scholar 

  46. Chigira M., Shinozaki T. 1990: Diagnostic value of serum tumor markers in skeletal metastasis of carcinomas. Arch. Orthop. Trauma Surg., 109, 247–251.

    Article  PubMed  CAS  Google Scholar 

  47. Daroca P.J. Jr., Reed R J, Martin P.C. 1990: Metastatic amelanotic melanoma simulating giant-cell tumor of bone. Hum. Pathol., 21, 978–980.

    Article  PubMed  Google Scholar 

  48. Kattapuram S.V., Khurana J.S., Scott J.A., EL-Khoury G.Y. 1990: Negative scintigraphy with positive magnetic resonance imaging in bone metastases. Skeletal Radiol., 19, 113–116.

    CAS  Google Scholar 

  49. Yazawa Y., Frassica F.J., Chao E.Y.S., Pritchard D.J., Sim F.H., Shives T.C. 1990: Metastatic bone disease. A study of the surgical treatment of 166 pathological humeral and femoral fractures. Clin. Orthop., 251, 213–219.

    PubMed  Google Scholar 

  50. Henriksson C., Haraldsson G., Aldenborg F., Lindberg S., Pettersson S. 1992: Skeletal metastases in 102 patients evaluated before surgery for renal cell carcinoma. Scand. J. Urol. Nephrol., 26, 363–366.

    Article  PubMed  CAS  Google Scholar 

  51. Tam Y., Yamaoka Y., Takayasu T., Ino K., Shimahara Y., Mori K., Morimoto T., Ozawa K. 1992: Bone metastases of hepatocellular carcinoma after liver resection. J. Surg. Oncol., 50, 12–18.

    Article  Google Scholar 

  52. Rougraff B.T., Kneisl J.S., Simon M.A. 1993: Skeletal metastases of unknown origin. A prospective study of a diagnostic strategy. J. Bone Joint Surg., 75-A, 1276–1281.

    Google Scholar 

  53. Vassilopoulou-Sellin R., Newman B.M., Taylor S.H., Guinee V.F. 1993: Incidence of hypercalcemia in patients with malignancy referred to a comprehensive Cancer Center. Cancer, 71, 1309–1312.

    Article  Google Scholar 

  54. Loda M., Fogt F., French F.S., Posner M., Cukor B., Aretz H.T., Alsaigh N. 1994: Androgen receptor immunohistochemistry on paraffin-embedded tissue. Mod. Pathol., 7, 388–391.

    PubMed  CAS  Google Scholar 

  55. Ratanatharathorn V., Powers W.E., Steverson N., Han I., Ahmad K., Grimm J. 1994: Bone metastasis from cervical cancer. Cancer, 73, 2372–2379.

    Article  PubMed  CAS  Google Scholar 

  56. IGou D., Sundaram M., Mcdonald D.J., Janney C., Chalk D.E. 1995: Appendicular metastatic prostate cancer simulating osteosarcoma, Paget’ s disease, and Paget’ s sarcoma. Skeletal Radiol., 24, 447–449.

    Article  PubMed  CAS  Google Scholar 

  57. Osborn J.L., Getzemberg R.H., Trump D.L. 1995: Spinal cord compression in prostate cancer. J. Neurooncol., 23, 135–147.

    Article  PubMed  CAS  Google Scholar 

  58. Townsend P.W., Smalley S.R., Cozad S.C., Rosenthal H.G., Hassanein R.E. 1995: Role of postoperative radiation therapy after stabilization of fractures caused by metastatic disease. Int. J. Radiat. Oncol. Biol. Phys., 31, 43–49.

    Article  PubMed  CAS  Google Scholar 

  59. Soderlund V. 1996: Radiological diagnosis of skeletal metastases. Eur. Radiol., 6, 587–595.

    Article  PubMed  CAS  Google Scholar 

  60. Tatsui H., Onomura T., Morishita S., Oketa M., Inoue T. 1996: Survival rates of patients with metastatic spinal cancer after scintigraphic detection of abnormal radioactive acumulation. Spine, 21, 2143–2148.

    Article  PubMed  CAS  Google Scholar 

  61. Jacobsen S., Stephensen S.L., Paaske B.P., Lie P.G., Lausten G.S. 1997: Skeletal metastases of unknown origin: a retrospective analysis of 29 cases. Acta Orthop. Belg., 63, 15–22.

    PubMed  CAS  Google Scholar 

Bone metastases in children

  1. Reilly D., Nesbt M.E., Krivit W. 1968: Cure of three patients who had skeletal metastases in disseminated neuroblastoma. Pediatrics, 41, 47–51.

    PubMed  CAS  Google Scholar 

  2. Marsden H.B., Lawler W. 1980: Bone metastasizing renal tumour of childhood: histopathological and clinical review of 38 cases. Virchows Arch., 387, 341–351.

    CAS  Google Scholar 

  3. Daubenton J.D., Fisher R.M., Ikarabus C.D., Mann M.D. 1987: The relationship between prognosis and scintigraphic evidence of bone metastases in neuroblastoma. Cancer, 59, 1586–1589.

    Article  PubMed  CAS  Google Scholar 

  4. Oppedal B.R., Storm Mathisen I., Kemshead J.T., Brandizaeg P. 1989: Bone marrow examination in neuroblastoma patients. A morphologic, immunocytochemical and immunohistochemical study. Hum. Pathol., 20, 800–805.

    Article  PubMed  CAS  Google Scholar 

  5. Hall-Craggs M.A., Shaw D., Pritchard J., Gordon I. 1990: Metastatic neuroblastoma: new abnormalities on bone scintigraphy may not indicate tumour recurrence. Skeletal Radiol., 19, 33–36.

    Google Scholar 

  6. Jacobs A., Delree M., Desprechins B., Otten J., Ferster A., Jonckheer M.H., Mertens J., Ham H.R., Piepsz A. 1990: Consolidating the role of I-Mibg-scintigraphy in childhood neuroblastoma: five years of clinical experience. Pediatr. Radiol., 20, 157–159.

    Article  PubMed  CAS  Google Scholar 

  7. Paul S.R., Tarbell N.J., Korf B., Kretschmar C.S., Lavally B., Grier H.E. 1991: Stage IV neuroblastoma in infants. Long-term survival. Cancer, 67, 1493–1497.

    Article  PubMed  CAS  Google Scholar 

  8. Shapeero L.G., Couanet D., Vanel D., Ackerman L.V., Terrier-Lacombe M.J., Flamant F., Con-Tesso G., Lumbroso J. 1993: Bone metastases as the presenting manifestation of rhabdomyosarcoma in childhood. Skeletal Radiol., 22, 433–438.

    Article  CAS  Google Scholar 

  9. Strother D., Shuster J.J., Mcwilliams N., Nitschke R., Smith E.I., Joshi V.J., Kun L., Hayes F.A., Castleberry R. 1995: Results of pediatric oncology group protocol 8104 for infants with stages D and DS neuroblastoma. J. Pediatr. Hematol. Oncol., 17, 254–259

    Article  PubMed  CAS  Google Scholar 

  10. Suc A., Lumbroso J., Rubie H., Hattchouel J.M., Boneu A., Rodary C., Robert A., Hartmann O. 1996: Metastatic neuroblastoma in children older than one year: prognostic significance of the initial metaiodobenzylguanidine scan and proposal for a scoring system. Cancer, 77, 805–811.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 1999 Springer-Verlag Wien

About this chapter

Cite this chapter

Campanacci, M. (1999). Metastatic Bone Disease. In: Bone and Soft Tissue Tumors. Springer, Vienna. https://doi.org/10.1007/978-3-7091-3846-5_49

Download citation

  • DOI: https://doi.org/10.1007/978-3-7091-3846-5_49

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-3848-9

  • Online ISBN: 978-3-7091-3846-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics