Giant Cell Tumor

Giant Cell Tumor of Bone, Osteoclastoma
  • Mario Campanacci


Giant cell tumor of bone is defined as an intramedullary bone tumor, with a specific predilection for age and location, composed of mononucleated cells and osteoclast-like multi-nucleated giant cells, and having a variable and unpredictable potential for growth1. The giant cell tumor usually behaves as a benign tumor, but has a significant tendency to recur locally and, rarely, may produce pulmonary metastases. These have the same histological features as the primary tumor and are frequently curable. Rarely, a giant cell tumor may transform into a high-grade sarcoma.


Local Recurrence Giant Cell Pulmonary Metastasis Pathologic Fracture Multinucleated Giant Cell 
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Giant cell tumor

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Copyright information

© Springer-Verlag Wien 1999

Authors and Affiliations

  • Mario Campanacci
    • 1
    • 2
  1. 1.University of BolognaItaly
  2. 2.Rizzoli Orthopaedic InstituteBolognaItaly

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