Histiocytic Fibroma

Fibroma, Non-Ossifying Fibroma, Non-Osteogenic Fibroma, Fibrous Defect of the Cortex, Fibrous Metaphyseal Defect, Fibrous Xanthoma, Histiocytic Xanthogranuloma
  • Mario Campanacci


It is an innocuous lesion originating eccentrically in the growing metaphysis and composed of histio-fibroblasts. It is usually asymptomatic and spontaneously regressing.


Giant Cell Fibrous Dysplasia Bone Cyst Giant Cell Tumor Distal Tibia 


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Histiocytic fibroma

  1. 1942.
    Jaffe H. L., Lichtenstein L. 1942: Non osteogenic fibroma of bone. Am. J. Pathol., 18, 205–221.PubMedGoogle Scholar
  2. 1945.
    Hatcher C. H. 1945: The pathogenesis of localized fibrous lesions in the metaphyses of long bones. Ann. Surg., 122, 1016–1030.CrossRefGoogle Scholar
  3. 1949.
    Ponseti I. V., Friedman B. 1949: Evolution of metaphyseal fibrous defects. J. Bone Joint Surg., 31A, 582–585.PubMedGoogle Scholar
  4. 1955.
    Caffey J. 1955: On fibrous defects in cortical walls of growing tubular bones: their radiologic appearance, structure, prevalence, natural course and diagnostic significance. Adv. Pediatr., 7, 13–51.PubMedGoogle Scholar
  5. 1956.
    Cunningham J.B., Ackerman L.V. 1956: Methaphyseal fibrous defects. J. Bone Joint Surg., 38A, 797–808.PubMedGoogle Scholar
  6. 1961.
    Selby S. 1961: Metaphyseal cortical defects in the tubular bones of growing children. J. Bone Joint Surg., 43A, 395–400.Google Scholar
  7. 1964.
    Morton K.S. 1964: Bone production in non-osteogenic fibroma. An attempt to clarify nomenclature in fibrous lesions of bone. J. Bone Joint Surg., 46B, 233–243.Google Scholar
  8. 1966.
    Berkin C.R. 1966: Non ossifying fibroma of bone. Br. J. Radiol., 39, 469–471.PubMedCrossRefGoogle Scholar
  9. 1972.
    Drennan D.B., Fahey J.J., Maylahn D.J. 1972: Fractures through large non ossifying fibromas. The operative and non-operative course to healing. J. Bone Joint Surg., 54A, 1794–1799.Google Scholar
  10. 1974.
    Drennan D.B., Maylahn D.J., Fahey J.J. 1974: Fractures through large nonossifying fibromas. Clin Orthop, 103, 82–88.PubMedCrossRefGoogle Scholar
  11. 1974.
    Steiner G.C. 1974: Fibrous cortical defect and nonossifying fibroma of bone: a study of the ultrastructure. Arch. Pathol., 97, 205–210.PubMedGoogle Scholar
  12. 1979.
    Laus M., Vicenzi G. 1979: Histiocytic fibroma of bone. Study of 170 cases Ital. J. Orthop. Traumatol., 5, 343–348.PubMedGoogle Scholar
  13. 1981.
    Arata M.A, Peterson H.A., Dahlin D.C. 1981: Pathological fractures through non ossifying fibromas. J. Bone Joint Surg., 63A, 980–988.PubMedGoogle Scholar
  14. 1982.
    Herrera G.A., Reimann B.E.F., Scully T.J., Difiore R.J. 1982: Non-ossifying fibroma. Clin. Orthop., 167, 269–276.PubMedGoogle Scholar
  15. 1988.
    Ritschl P., Karnel F., Hajek P. 1988: Fibrous metaphyseal defects. Determination of their origin and natural history using a radiomorphological study. Skeletal Radiol, 17, 8–15.PubMedCrossRefGoogle Scholar
  16. 1989.
    Ritschl P., Hajek P.C., Pechmann U. 1989: Fibrous metaphyseal defects. Magnetic resonance imaging appearances. Skeletal Radiol, 18, 253–259.PubMedCrossRefGoogle Scholar
  17. 1990.
    Ritschl P., Lintner F., Pechmann U., Brand G. 1990: Fibrous metaphyseal defect. Int. Orthop., 14, 205–211PubMedCrossRefGoogle Scholar
  18. 1994.
    Araki Y., Tanaka H., Yamamoto H., Yamamoto T., Tsukaguchi I., Shino K. Nakamura H. 1994: Mri of fibrous cortical defect of the femur. Radiat. Med., 12, 93–98.PubMedGoogle Scholar

Multiple histiocytic fibromas with extraskeletal anomalies

  1. 1978.
    EvAns G.A.. Park W.M. 1978: Familial multiple non-osteogenic fibromata. J. Bone Joint Surg., 60B, 416419.Google Scholar
  2. 1982.
    Mirra J.M., Gold R.H., Rand F. 1982: Disseminated non-ossifying fibromas in association with cafe-au-lait spots (Jaffe-Campanacci Syndrome). Clin. Orthop., 168, 192–205.PubMedGoogle Scholar
  3. 1983.
    Campanacci M., Laus M., Boriani S. 1983: Multiple non-ossifying fibromata with extraskeletal anomalies: a new syndrome? J. Bone Joint Surg., 65B, 627–632.Google Scholar
  4. 1987.
    Moser R.P., Sweet D.E., Haseman D.B., Madewell J.E. 1987: Multiple skeletal fibroxanthomas. Radiologic-pathologic correlation of 72 cases. Skeletal Radiol, 16, 353–359.PubMedCrossRefGoogle Scholar
  5. 1988.
    Blau R.A., Zwick D.L., Westphal R.A. 1988: Multiple non-ossifying fibromas. J. Bone Joint Surg., 70A, 299–304.PubMedGoogle Scholar
  6. 1992.
    Scotland H.M., Eldridge R., Sommer S.S., Malawer M.M. 1992: Neurofibromatosis 1 and osseous fibrous dysplasia in a family. Am. J. Med. Genet., 43, 815–822.CrossRefGoogle Scholar
  7. 1994.
    Kotzot D., Stoss H., Wagner H., Ulmer R. 1994: Jaffe-Campanacci syndrome: case report and review of literature. Clin. Dysmorphol, 3, 328–334.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Wien 1999

Authors and Affiliations

  • Mario Campanacci
    • 1
    • 2
  1. 1.University of BolognaItaly
  2. 2.Rizzoli Orthopaedic InstituteBolognaItaly

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