Multiple Chondromas

chondromatosis, Ollier’s disease, Maffucci’s syndrome Definition
  • Mario Campanacci


Multiple chondromas, unlike multiple exostoses, are not hereditary, are very variable in number and extent, and tend to prevail in one side of the body. When the chondromas are more extensively distributed, the term of O11ier’s disease is also employed. Multiple chondromas associated with soft tissues hemangiomas are known as Maffucci’s syndrome. Extensive multiple chondromas cause shortening and deformity of the affected bones, and undergo a frequent transformation into a chondrosarcoma.


Fibrous Dysplasia Fibrous Histiocytoma Cavernous Hemangioma Limb Length Discrepancy Dedifferentiated Chondrosarcoma 
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  1. Maffucci A.: 1881 Di un caso di encondroma ed angioma multiplo: contribuzione alla genesi embrionale dei tumori. Mov. Med. Chir. Nap., 13, 399–412.Google Scholar
  2. Cowan W. K.: 1965 Malignant change and multiple metastases in 011ier’s disease. J. Clin. Pathol., 18, 650653.Google Scholar
  3. Braddock G.T.F., Hadlow V.D.: 1966 Osteosarcoma in enchondromatosis (011ier’s disease). Report of a case. J. Bone Joint Surg., 48-B, 145–149.Google Scholar
  4. Lewis R.J., Ketcham A.S.: 1973 Maffucci’s syndrome: functional and neoplastic significance. Case report and review of the literature. J. Bone Joint Surg., 55-A, 1465–1479.Google Scholar
  5. Goodman S.B., Bell R.S., Fornasier V.L., De Demeter D., Bateman J.E: 1984 011ier’s disease with multiple sarcomatous transformations. Hum. Pathol., 15, 91–93.Google Scholar
  6. Cannon S.R., Sweetnam D.R.: 1985 Multiple chondrosarcomas in dyschondroplasia (011ier’s disease). Cancer, 55, 836–840.PubMedCrossRefGoogle Scholar
  7. Davidson T.I., Kissin M.W., Bradish C.F., Westbury G.: 1985 Angiosarcoma arising in a patient with Maffucci syndrome. Eur. J. Surg. Oncol., 11, 381–384.PubMedGoogle Scholar
  8. Sun T.C., Swee R.G., Shives T.C., Unni K.K.: 1985 Condrosarcoma in Maffucci’s syndrome. J. Bone Joint Surg., 67-A, 1214–1219.Google Scholar
  9. Azouz E.M.: 1987 Case report 418. Multiple enchondromatosis (Oilier disease) with severe vertebral changes. Skeletal Radiol., 16, 236–239.PubMedCrossRefGoogle Scholar
  10. Liu J., Hudkins P., Swee R.G., Unni K.K.: 1987 Bone sarcomas associated with 011ier’s disease. Cancer, 59, 1376–1385.PubMedCrossRefGoogle Scholar
  11. Mitchell M.L., Ackerman L.V.: 1987 Case report 405. Oilier disease (enchondromatosis). Skeletal Radiol., 16, 61–66.PubMedCrossRefGoogle Scholar
  12. Schwartz H.S., Zimmerman N.B., Simon M.A., Wroble R.R., MillarE.A., BONFIGLIO M.: 1987 The malignant potential of enchondromatosis. J. Bone Joint Surg., 69-A, 269–274.Google Scholar
  13. Lucas D., Tupler R., EnnekingW.F.: 1990 Multicentric chondrosarcomas associated with 011ier’s disease: review and case report. J. Fla. Med. Assoc., 77, 24–28.PubMedGoogle Scholar
  14. Tsuchiya H., Tomita K., Yasutake H., Takagi Y., Ueda Y., Kadoya M: 1991 Maffucci’s syndrome combined with dedifferentiated chondrosarcoma. Arch. Orthop. Trauma Surg., 110, 269–272.Google Scholar
  15. Weyl-Ben Arush M., Oslander L.: 1991 011ier’s disease associated with ovarian Sertoli-Leydig cell tumor and breast adenoma. Am. J. Pediatr. Hematol. Oncol., 13, 49–51.Google Scholar
  16. Chang S., Prados M.D.: 1994 Identical twins with 011ier’s disease and intracranial gliomas: case report. Neurosurgery, 34, 903–906.PubMedCrossRefGoogle Scholar
  17. D’angelo G., Petas N., Donzelli O.: 1996 Lengthening of the lower limbs in 011ier’s disease: problems related to surgery. Chir. Organi Mov., 81, 279–285.PubMedGoogle Scholar

Copyright information

© Springer-Verlag Wien 1999

Authors and Affiliations

  • Mario Campanacci
    • 1
    • 2
  1. 1.University of BolognaItaly
  2. 2.Rizzoli Orthopaedic InstituteBolognaItaly

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