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Detoxifikation mit Opiat-Antagonisten

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Opiatabhängigkeit
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Zusammenfassung

Die Gabe des Opiatantagonisten Naloxon zur Therapie des Opiatentzuges wurde erstmals 1971 von Zaks und Mitarbeitern (1) beschrieben. Sie verabreichten Nalo-xonhydrochlorid bei 7 Patienten mit Opiatabhängigkeit. 1975 wurde von Blachley und Mitarbeiter (2) sowie Resnick und Mitarbeiter (3) die intravenöse Gabe beschrieben. Sie infundierten den Opiatantagonisten Naloxon fraktioniert in zeitlichen Abständen Patienten mit Opiatabhängigkeit intravenös und konnten damit nicht nur Entzugsymptome erzeugen, sondern vor allem die Dauer der gesamten Entzugsperiode verkürzen.

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Literatur

  1. Zaks A, Jones T, Fink M, Freedman AM (1971) Naloxone treatment of opiate dependence. JAMA 215: 2108–2110

    Article  PubMed  CAS  Google Scholar 

  2. Blachley P, Casey D, Marcel L, Denney D (1975) Rapid detoxification from heroin and methadone using naloxine: A model for study of the treatment of the opiate abstinence syndrome. In: Senay E, Shorty V, Alkenese H (eds) Developments in the field of drug abuse. Schenkman Publishing, Cambridge Massachusetts, pp 327–336

    Google Scholar 

  3. Resnick R, Kestenbaum R, Gastanaga P, Volavka J, Freedman AM (1975) Experimental techniques for rapid withdrawal from methadone maintenance: Results of pilot trials. In: Senay E, Shorty V, Alkenese H (eds) Developments in the field of drug abuse. Schenkman Publishing, Cambridge, Massachusetts, pp 321–327

    Google Scholar 

  4. Meyer DR, Sparber SB (1976) Clonidine antagonized body weight loss and other symptoms used to measure withdrawl in morphine-pelleted rats given naloxone. Pharmacologist 18: 236–239

    Google Scholar 

  5. Aghajanian GK (1982) Central noradrenergic neurons: a locus for the functional interplay between alpha-2-noradrenoceptors and opiate receptors. J Clin Psychiatry 43: 20–24

    PubMed  CAS  Google Scholar 

  6. Gold MS, Redmonds DE, Kleber HD (1978) Clonidin in opiate withdrawal. Lancet I: 929–930

    Google Scholar 

  7. Riordan CE, Kleber HD (1980) Rapid opiate detoxification with Clonidine and naloxon. Lancet I: 1079–1080

    Google Scholar 

  8. O’Connor PG, Caroll KM, Shi JM, Schottenfeld RS, Kosten TR, Rounsville BJ (1997) Three methods of opioid detoxification in a primary setting: A randomised trial. Ann Intern Med 127: 526–530

    Article  PubMed  Google Scholar 

  9. Gerra G, Zaimovic A, Giusti F, DiGennaro C, Zambelli U, Gardini S, Selsignore R (2001) Lofexidine versus Clonidine in rapid opiate detoxification. J Subst Abuse Treatment 21: 11–17

    Article  CAS  Google Scholar 

  10. Loimer N, Lenz K, Schmid R, Presslich O (1991) Technique for greatly shortening the transition from methadone to naltrexone maintenance of patients addicted to opiates. Am J Psychiatry 148: 933–935

    PubMed  CAS  Google Scholar 

  11. Seoane A, Carrasco G, Cabre L, Puiggros A, Hernandez E, Alvarez M, Costa J, Molina R, Sobrepere G (1997) Efficacy and safety of two new methods of rapid intravenous detoxification in heroin addicts previously treated without success. Brit J Psychiatry 171: 340–45

    Article  CAS  Google Scholar 

  12. Bell JR, Young MR, Masterman SC, Morris A, Mattick RP, Bammer G (1999) A pilot study of naltrexone accelerated detoxification in opioid dependent patients. Med J Australia 171: 26–30

    PubMed  CAS  Google Scholar 

  13. Presslich O, Loimer N, Lenz K, Schmid R (1989) Opiate detoxification under general anesthesia by large doses of naloxone. Clinical Toxicology 27: 263–270

    Article  PubMed  CAS  Google Scholar 

  14. Loimer N, Schmid R, Lenz K, Presslich O, Grünberger G (1990) Acute blocking of naloxone precipitated opiate withdrawal symptoms by methohexital. Brit J Psychiatry 157:748–752

    Article  CAS  Google Scholar 

  15. Loimer N, Schmid RW, Presslich O, Lenz K (1989) Continuous naloxone administration supresses opiate withdrawal symptoms in human opiate addicts during detoxificatin treatment. J Psychiat Res 23: 81–86

    Article  PubMed  CAS  Google Scholar 

  16. Bartter T, Gooberman LL (1996) Rapid Opiate detoxification. Am J Drug Ale Abuse 22:489–495

    Article  CAS  Google Scholar 

  17. Legarda JJ, Gossop M (1994) A 24h inpatient detoxification treatment for heroin addicts: a preliminary investigation. Drug and Alcohol Dependence 35: 91–93

    Article  PubMed  CAS  Google Scholar 

  18. Brewer C (1997) Ultra rapid, antagonist precipitated opiate detoxification under general anesthesia or sedatio. Addict Biol 291–302

    Google Scholar 

  19. Hensel M, Kox WJ (2000) Safety, efficacy and long term results of a modified version of rapid opiate detoxification under general anesthesia: A prospective study in methadone, heroin, codeine and morphine addicts. Acta Anaesthesiol Scan 44: 326–333

    Article  CAS  Google Scholar 

  20. Scherbaum N, Klein S, Kaube H, Kienbaum P, Peters J, Gostpur M (1998) Alternative strategies of opiate detoxification: Evaluation of the so called ultrarapid detoxification. Pharmacopsychiatry 31: 205–209

    Article  PubMed  CAS  Google Scholar 

  21. Loimer N, Lenz K (2001) NUKE — Praxisorientierte Modifikation des Narkoseentzugs (in Vorbereitung)

    Google Scholar 

  22. Kienbaum P, Thürauf N, Michel MC, Scherbaum N, Gastpar M, Peters J (1998) Profound increase in epinephrine concentration in plasma and cardiovascular stimulation after opioid receptor blockade in opioid addicted patients during barbiturate induced anesthesia for acute detoxification Anesthesiology 88: 1154–1161

    Article  PubMed  CAS  Google Scholar 

  23. Elman I, Dàmbra MN, Krause S, Breiter H, Kane M, Morris R, Tuffy L, Gastfriend DR (2001) Ultrarapid opioid detoxification: Effects on cardiopulmonary physiology, stress hormones and clinical outcomes. Drug and Alcohol Dependence 163–172

    Google Scholar 

  24. Pfab R, Zilker T (1999) Opiate detoxification under anesthesis: No apparent benefit but suppression of thyroid hormones and rish of pulmonary and renal faiure. Clinical Toxicology 37:43–50

    Article  PubMed  CAS  Google Scholar 

  25. Lenz K, Fritsch N, Pixner N, Kapral C, Ko P, C, Wewalka F (2001) Effektivität einer Hochdosistherapie mit Protonenpumpen-blockern zur Stressulkusprophylaxe. Z Gastroenterol 39: 881; Abstr AG 14

    Google Scholar 

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© 2003 Springer-Verlag Wien

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Lenz, K., Loimer, N. (2003). Detoxifikation mit Opiat-Antagonisten. In: Beubler, E., Haltmayer, H., Springer, A. (eds) Opiatabhängigkeit. Springer, Vienna. https://doi.org/10.1007/978-3-7091-3796-3_16

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  • DOI: https://doi.org/10.1007/978-3-7091-3796-3_16

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-83793-1

  • Online ISBN: 978-3-7091-3796-3

  • eBook Packages: Springer Book Archive

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