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Mitomycin C

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Original articles

  1. Rentschler R, Wilbur D: Pyridoxine: a potential local antidote for mitomycin-C extravasation. J Surg Oncol 37: 269–271, 1988.

    Article  PubMed  CAS  Google Scholar 

  2. Argenta LC, Manders EK: Mitomycin C extravasation injuries. Cancer 51: 1080–1082, 1983.

    Article  PubMed  CAS  Google Scholar 

  3. Bertelli G, Dini D, Forno G, et al: Dimethylsulphoxide and cooling after extravasation of antitumour agents. Lancet 341: 1098–1099, 1993.

    Article  PubMed  CAS  Google Scholar 

  4. Bertelli G, Gozza A, Forno GB, et al: Topical dimethylsulfoxide for the prevention of soft tissue injury after extravasation of vesicant cytotoxic drugs: a prospective clinical study. J Clin Oncol 13: 2851–2855, 1995.

    PubMed  CAS  Google Scholar 

  5. Tsavaris NB, Komitsopoulou P, Karagiaouris P, et al: Prevention of tissue necrosis due to accidental extravasation of cytostatic drugs by a conservative approach. Cancer Chemother Pharmacol 30: 330–333, 1992.

    Article  PubMed  CAS  Google Scholar 

  6. Tsavaris NB, Karagiaouris P, Tzannou I, et al: Conservative approach to the treatment of chemotherapy-induced extravasation. J Dermatol Surg On-col 16: 519–522, 1990.

    CAS  Google Scholar 

  7. Ludwig CU, Stoll HR, Obrist R, et al: Prevention of cytotoxic drug induced skin ulcers with dimethyl sulfoxide (DMSO) and a-tocopherole. Eur J Cancer Clin Oncol 23: 327–329, 1987.

    Article  PubMed  CAS  Google Scholar 

  8. Khanna AK, Khanna A, Asthana AK, et al: Mitomycin C extravasation ulcers. J Surg Oncol 28: 108–110, 1985.

    Article  PubMed  CAS  Google Scholar 

  9. Bowers DG, Lynch JB: Adriamycin extravasation. Plast Reconstr Surg 61: 86–92, 1978.

    Article  PubMed  Google Scholar 

  10. Fuller B, Lind M, Bonomi P: Mitomycin C extravasation exacerbated by sunlight. Ann Intern Med 94: 542, 1981.

    Article  PubMed  CAS  Google Scholar 

  11. Moertel CG, Reitemeier RJ, Hahn RG: Mitomycin C therapy in advanced gastrointestinal cancer. JAMA 204: 111–114, 1968.

    Article  Google Scholar 

  12. Alberts DS, Dorr RT: Case report: topical DMSO for mitomycin-C-induced skin ulceration. Oncol Nurs Forum 18: 693–695, 1991.

    PubMed  CAS  Google Scholar 

  13. Aizawa H, Tagami H: Delayed tissue necrosis due to mitomycin C. Acta Derm Venereol 67: 364–366, 1987.

    PubMed  CAS  Google Scholar 

  14. Herrera D, Burnham N: DMSO and extravasation of mitomycin. Oncol Nurs Forum 16: 155, 1989.

    PubMed  CAS  Google Scholar 

  15. Wood HA, Ellerhorst-Ryan JM: Delayed adverse skin reactions associated with mitomycin-C administration. Oncol Nurs Forum 11: 14–18, 1984.

    PubMed  CAS  Google Scholar 

  16. Bartkowski-Dodds L, Reville B: Extensive tissue ulceration due to apparent sensitivity reactions to mitomycin. Cancer Treat Rep 69: 925–927, 1985.

    PubMed  CAS  Google Scholar 

Secondary literature

  1. Bertelli G: Prevention and management of extravasation of cytotoxic drugs. Drug Safety 12: 245–255, 1995.

    Article  PubMed  CAS  Google Scholar 

  2. Schneider G: Paravasate von Zytostatika. Diagnostik und Therapie. Aina S. Schneider Verlag, 6th edition: 1–17, 1999.

    Google Scholar 

  3. Krämer I: Onkologische Pharmazie. In: Jaehde U, Radziwill R, Mühlebach S, et al (eds) Lehrbuch der Klinischen Pharmazie. Wissenschaftliche Verlagsgesellschaft mbH, 1st edition: 268–269, 1998.

    Google Scholar 

  4. Ignoffo RJ, Friedman MA: Therapy of local toxicities caused by extravasation of cancer chemotherapeutic drugs. Cancer Treat Rev 7: 17–27, 1980.

    Article  PubMed  CAS  Google Scholar 

  5. Gain M, Melzer S, Meyer-Jürshof A, et al: Mitomycin: Behandlung von Paravasaten. In: Gain M, et al (eds) ADKA-Zytostatika-Handbuch. Verlag Heiner Biller, Vol 1, 2nd edition: 35, 1997.

    Google Scholar 

  6. Dorr RT: Pharmacologic management of vesicant chemotherapy extravasations. In: Dorr RT, Von Hoff DD (eds) Cancer Chemotherapy Handbook. Appleton & Lange, 2nd edition: 109–118, 1994.

    Google Scholar 

  7. Stanley A: Managing complications of chemotherapy. In: Allwood M, Stanley A, Wright P (eds) The Cytotoxics Handbook. Radcliffe Medical Press, 3rd edition: 105–124, 1997.

    Google Scholar 

  8. Mullin S, Beckwith MC, Tyler LS: Prevention and management of antineoplastic extravasation injury. Hosp Pharm 35: 57–76, 2000.

    Google Scholar 

  9. Schneider SM, Distelhorst CW: Chemotherapy-induced emergencies. Semin Oncol 16: 572–578, 1989.

    PubMed  CAS  Google Scholar 

  10. Dorr RT: Antidotes to vesicant chemotherapy extravasations. Blood Rev 4: 41–60, 1990.

    Article  PubMed  CAS  Google Scholar 

  11. Gain M, Melzer S, Meyer-Jürshof A, et al: Allgemeiner Teil: Behandlung von Paravasaten. In: Gain M, et al (eds) ADKA-Zytostatika-Handbuch. Verlag Heiner Biller, Vol 1, 2nd edition: A42–44, 1997.

    Google Scholar 

  12. Barth J: Paravasate und deren Behandlung. In: Barth J (ed) ZytostatikaHerstellung in der Apotheke. Deutscher Apotheker Verlag, chapter VI-3: 1–9, 2000.

    Google Scholar 

  13. Cox K, Stuart-Harris R, Abdini G, et al: The management of cytotoxicdrug extravasation: guidelines drawn up by a working party for the Clinical Oncological Society of Australia. Med J Aust 148: 185–189, 1988.

    PubMed  CAS  Google Scholar 

Further reading

  1. Averbuch SD, Boldt M, Gaudiano G, et al: Experimental chemotherapy-induced skin necrosis in swine. J Clin Invest 81: 142–148, 1988.

    Article  PubMed  CAS  Google Scholar 

  2. Dorr RT, Soble MJ, Liddil JD, et al: Mitomycin C skin toxicity studies in mice: reduced ulceration and altered pharmacokinetics with topical dim-ethyl sulfoxide. J Clin Oncol 4: 1399–1404, 1986.

    PubMed  CAS  Google Scholar 

  3. Hahn SM, Sullivan FJ, De Luca AM, et al: Protection of mitomycin C induced skin extravasation with the nitroxide, 3-carbamoyl-proxyl (3CP). Int J Oncol 10: 119–123, 1997.

    PubMed  CAS  Google Scholar 

  4. Ignoffo RJ, Tomlin W, Rubinstein E, et al: A model for skin toxicity of antineoplastic drugs: doxorubicin (DOX), mitomycin-C (MMC), and vincristine (VCR). Clin Res 29: 437A, 1981.

    Google Scholar 

  5. Johnston-Early A, Cohen MH: Mitomycin C-induced skin ulceration remote from infusion site. Cancer Treat Rep 65: 529, 1981.

    PubMed  CAS  Google Scholar 

  6. Loth TS, Eversmann WW: Treatment methods for extravasations of chemotherapeutic agents: a comparative study. J Hand Surg 11A: 388–396, 1986.

    CAS  Google Scholar 

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© 2003 Springer-Verlag Wien

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Mader, I., Fürst-Weger, P.E., Mader, R.M., Semenitz, E.I., Terkola, R., Wassertheurer, S.M. (2003). Mitomycin C. In: Extravasation of Cytotoxic Agents. Springer, Vienna. https://doi.org/10.1007/978-3-7091-3710-9_37

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  • DOI: https://doi.org/10.1007/978-3-7091-3710-9_37

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-3712-3

  • Online ISBN: 978-3-7091-3710-9

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