Sjogren’s Syndrome

  • Robert I. Fox


The term Sjogren’s syndrome (SS) refers to xeropthalmia and xerostomia due to lymphocytic infiltrates of lacrimal and salivary glands. The condition may exist as a primary entity (primary SS, 1° SS) or in association with other autoimmune disorders such as systemic lupus erythematosus (SLE), dermatomyositis, scleroderma or rheumatoid arthritis (in which the sicca symptoms are termed “secondary” SS, 2° SS). The criteria for diagnosis of primary SS has been controversial. The absence of a uniformly accepted criteria has led to confusion in clinical practice and in the research literature. For example, only 15% of patients that fulfill European (EEC) criteria for SS would fulfill the San Diego criteria. This difference in disease classification leads to difficulty in comparing clinical trials and in elucidating pathogenetic mechanisms, since different patient populations are evaluated. However, a new international criteria has been suggested and will be presented since the final version of this criteria is close to acceptance by rheumatologists and government agencies.


Salivary Gland Systemic Lupus Erythematosus Patient Congenital Heart Block Subacute Cutaneous Lupus Erythematosus Sicca Symptom 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  • Robert I. Fox

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