• Catherine H. Orteu
  • Jan P. Dutz
  • Nicolas Hunzelmann
  • Thomas Krieg


Localized scleroderma (LS) or morphea encompasses a group of disorders characterized by limited and localized inflammatory sclerosis (thickening) and fibrosis of the skin, subcutaneous tissue, fascia and/or adjacent muscle. In contrast to systemic sclerosis, Raynaud’s phenomenon, acrosclerosis and internal organ involvement do not usually occur. Morphea may be divided into five subtypes: plaque, generalized, bullous, linear and deep, based on the extent, form and depth of cutaneous sclerosis (Peterson et al. 1995). These subtypes frequently occur together in the same patient. Although morphea is rarely life threatening, significant morbidity and disability occur, particularly in the linear and deep forms.


Systemic Sclerosis Connective Tissue Growth Factor Lichen Sclerosus Progressive Systemic Sclerosis Localize Scleroderma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer-Verlag Wien 2001

Authors and Affiliations

  • Catherine H. Orteu
  • Jan P. Dutz
  • Nicolas Hunzelmann
  • Thomas Krieg

There are no affiliations available

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