Pathogenesis of Autoimmune Disease

  • Martin Röcken
  • Tilo Biedermann


The term autoimmunity signifies the presence of specific memory-type immune reactions that are directed against one or more self-epitopes. Under most conditions, autoimmunity is determined in terms of immunoglobulins that react with either unknown or well-defined human antigens. Today it is supposed that the production of these autoantibodies requires prior activation of potentially autoreactive B cells by memory T cells. These T cells not only have to recognize a closely related peptide structure. Importantly, these T cells can stimulate B cells only when primed by activated antigen presenting cells.


Major Histocompatibility Complex Bullous Pemphigoid Major Histocompatibility Complex Molecule Peripheral Tolerance Inflammatory Autoimmune Disease 


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© Springer-Verlag Wien 2001

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  • Martin Röcken
  • Tilo Biedermann

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