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P System

  • Helmut Schenkel-Brunner

Abstract

The first antigen of the blood group P system, P 1 , was discovered in 1927 by Landsteiner and Levine [51]; the system was expanded in 1935 when the antigens P [82] and P k [44,45,65] were discovered and shown to be part of the P system. Five blood group P phenotypes can be defined according to the presence or absence of these three serological specificities on the erythrocytes, two of which, P 1 , and P 2 , are frequent and three, P 1 k , P 2 k , and p, very rare (Tab. 8.1) [81]:
  • P 1 , erythrocytes are characterised by the presence of P 1 , and P antigen

  • P 2 cells lack the P antigen

  • in P 1 k and P 2 k erythrocytes the P determinant is absent and the cells show strong P k activity; the presence of P 1 antigen distinguishes the P 1 k phenotype from P 2 k ,

  • none of the three antigenic characters are detectable on p cells (see Tab. 8.2).

Keywords

Blood Group Erythrocyte Membrane Hydatid Cyst Cold Agglutinin Blood Group System 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Allen, F.H., Marsh, W.L., Jensen, L. & Fink, J. (1974): Anti-IP: an antibody defining another product of interaction between the genes of the I and P blood group systems. Vox Sang. 27, 442–446.CrossRefGoogle Scholar
  2. 2.
    Ando, S. & Yamakawa, T. (1973): Separation of polar glycolipids from human red blood cells with special reference to blood group A activity. J. Biochem., Tokyo 73, 387–396.Google Scholar
  3. 3.
    Ando, S., Isobe, M. & Nagai, Y. (1976): High performance preparative column chromatography of lipids using a new porous silica, iatrobeads. I. Separation of molecular species of sphingoglycolipids. Bloch/m. Blophys. Acta 424, 98–105.Google Scholar
  4. 4.
    Anstee, D.J. & Pardoe, G.J. (1973): Structural aspects of heterologous blood-group-P, substance. Eur.1. Biochem. 39, 149–156.CrossRefGoogle Scholar
  5. 5.
    Anstee, D.J., Holt, P.D.J. & Pardoe, G.I. (1973): Agglutinins from fish ova defining blood groups B and P. Vox Sang. 25, 347–360.PubMedCrossRefGoogle Scholar
  6. 6.
    Anstee, D.J. & Tanner, M.J.A. (1974): The distribution of blood-group antigens on butanol extraction of human erythrocyte ‘ghosts’. Biochem. J. 138, 381–386.PubMedGoogle Scholar
  7. 7.
    Bailly, P., Piller, F., Cartron, J.P., Leroy, Y. & Fournet, B. (1986): Identification of UDP-galactose:lactose (lactosylceramide) a-4 and ß-3 galactosyltransferases in human kidney. Biochem. Biophys. Res. Commun 141, 84–91.PubMedCrossRefGoogle Scholar
  8. 8.
    Bailly, P., Chevaleyre, J., Sondag, D., François-Gérard, C., Piquet, Y., Vezon, G. & Cartron, J.P. (1987): Characterization of a murine monoclonal antibody specific for the human P1 blod group antigen. Mol. /mmuno% 24, 171–176.CrossRefGoogle Scholar
  9. 9.
    Bailly, P., Piller, F., Gillard, B., Veyrières, A., Marcus, D.M. & Cartron, J.P. (1992): Biosynthesis of the blood group Pk and P, antigens by human kidney microsomes. Carbohydr. Res. 228, 277–287.PubMedCrossRefGoogle Scholar
  10. 10.
    Bevan, B., Hammond, W. & Clarke, R.L. (1970): Anti-P, associated with liver-fluke infection. Vox Sang. 18, 188–189.PubMedCrossRefGoogle Scholar
  11. 11.
    Booth, P.B. (1970): Anti-ITP,: an antibody showing a further association between the I and P blood group systems. Vox Sang. 19, 85–90.PubMedCrossRefGoogle Scholar
  12. 12.
    Breimer, M.E., Cedergren, B., Karlsson, K.A., Nilson, K. & Samuelsson, B.E. (1980): Glycolipid pattern of stomach tissue of a human with the rare blood group A,p. FEBS Lett. 118, 209–211.PubMedCrossRefGoogle Scholar
  13. 13.
    Bruce, M., Watt, A., Gabra, G.S., Mitchell, R., Lakhesar, D. & Tippett, P. (1988): LKE red cell antigen and its relationship to P, and Pk: serological study of a large family. Vox Sang. 55, 237–240.PubMedCrossRefGoogle Scholar
  14. 14.
    Cameron, G.L. & Staveley, J.M. (1957): Blood-group P substance in hydatid cyst fluids. Nature 179, 147–148.PubMedCrossRefGoogle Scholar
  15. 15.
    Cory, H.T., Yates, A.D., Donald, A.S.R., Watkins, W.M. & Morgan, W.T.J. (1974): The nature of the human blood group P, determinant. B/ochem. Biophys. Res. Commun. 61, 1289–1296.CrossRefGoogle Scholar
  16. 16.
    Dahmen, J., Frejd, T., Magnusson, G., Noori, G., & Carlström, A.S. (1984): Synthesis of spacer-arm, lipid, and ethyl glycosides of the trisaccharide portion [a-D-Gal-(1–4)-3-D-Gal-(1–4)-13-D-Glc] of the blood-group Pk antigen: Preparation of neoglycoproteins. Carbohydr. Res 127, 15–25.PubMedCrossRefGoogle Scholar
  17. 17.
    Dahmen, J., Frejd, T., Magnusson, G., Noori, G. & Carlstrbm, A.S. (1984): Synthesis of spacer-arm, lipid, and ethyl glycosides of the terminal trisaccharide [a-D-Gal-(1—(4)-13-D-Gal-(1—(4)-0-D-GIcNAc] portion of the blood-group P, antigen: preparation of neoglycoproteins. Carbohydr. Res. 129, 63–71.PubMedCrossRefGoogle Scholar
  18. 18.
    Donath, J. & Landsteiner, K. (1904): Über paroxysmale Hämoglobinurie. Mönch. Med. Wschr. 51, 1590–1593.Google Scholar
  19. 19.
    Engelfriet, C.P., Beckers, D., von dem Borne, A.E.G.K., Reynierse, E. & van Loghem, J.J. (1971): Haemolysins probably recognizing the antigen p. Vox Sang. 23, 176–181.CrossRefGoogle Scholar
  20. 20.
    Fellous, M., Gerbai, A., Kamoun, M., Chereau, C., Jullien, A. & Dumont, J. (1977): Studies on the P and ABO red blood cell systems using somatic cell genetics. In: Human Blood Groups, Proceedings of the 5th International Convocation on Immunology, Buffalo 1976, (J.F. Mohn, R.W. Plunkett, R.K. Cunningham & R.M. Lambert, eds.), Karger, Basel, pp. 417–425.Google Scholar
  21. 21.
    Fellous, M., Gerbai, A., Nobillot, G. & Wiels, J. (1977): Studies on the biosynthesic pathway of human P erythrocyte antigen using genetic complementation tests between fibroblasts from rare p and Pk phenotype donors. Vox Sang. 32, 262–268.PubMedCrossRefGoogle Scholar
  22. 22.
    Fellous, M., Hors, M.C. & Rebourcet, R. (1977): The expression and relation of HLA, ß2 microglobulin, and receptor for marmoset red cells on man/mouse and man/Chinese hamster hybrid cells. Eur. J. /mmuno% 7, 22–30.CrossRefGoogle Scholar
  23. 23.
    Fellous, M., Cartron, J.P., Wiels, J. & Tursz, T. (1985): A monoclonal antibody against a Burkitt lymphoma associated antigen has an anti-Pk red blood cell specificity. Brit. J. Haematol. 60, 559–565.CrossRefGoogle Scholar
  24. 24.
    Fletcher, K.S., Bremer, E.G. & Schwarting, G.A. (1979): P blood group regulation of glycosphingolipid levels in human erythrocytes. J. Biol. Chem. 254, 11196–11198.PubMedGoogle Scholar
  25. 25.
    François-Gérard, C., Brodeur, J. & André, A. (1980): Turtledove: a new source of P1-like material cross-reacting with the human erythrocyte antigen. Vox Sang. 39, 141–148.PubMedCrossRefGoogle Scholar
  26. 26.
    François-Gérard, C., Brodeur, J., André, A., Gerday, C., Pierce-Cretei, A., Montreuil, J. & Spik, G. (1980): Demonstration of the existence of a specific blood-group P, antigenic determinant in turtle-dove ovomucoid. Blood Transf. lmmunohaemato/. 23, 579–588.Google Scholar
  27. 27.
    Graham, H.A. & Williams, A.N. (1980): A genetic model for the inheritance of the P, P, and Pk antigens. /mmuno% Commun. 9, 191–201.Google Scholar
  28. 28.
    Haataja, S., Tikkanen, K., Liukkonen, J., François-Gérard, C. & Finne, J. (1993): Characterization of a novel bacterial adhesion specificity of Streptococcus suis recognizing blood group P receptor oligosaccharides. J. Biol. Chem. 268, 4311–4317.PubMedGoogle Scholar
  29. 29.
    Haselberger, C. & Schenkel-Brunner, H. (1982): Evidence for erythrocyte membrane glycoproteins of being the predominant carriers of blood group P, determinants. FEBS Lett. 149, 126–128.PubMedCrossRefGoogle Scholar
  30. 30.
    Inglis, G., Fraser, R.H., Mitchell, A.A.B., Mackie, A., Allan, E.K. & Mitchell, R. (1987): Serological characterization of a mouse monoclonal anti-P-like antibody. Vox Sang. 52, 79–82.PubMedCrossRefGoogle Scholar
  31. 31.
    Iseki, S., Masaki, S. & Levine, P. (1954): A remarkable family with the rare human isoantibody anti-Tj° in four siblings; anti-Tj° and habitual abortion. Nature 173, 1193–1194.PubMedCrossRefGoogle Scholar
  32. 32.
    Issitt, C.H., Duckett, J.B., Osborne, B.M., Gut, J.B. & Beasley, J. (1976): Another example of an antibody reacting optimally with p red cells. Brit. J. Haematol. 34, 19–22.CrossRefGoogle Scholar
  33. 33.
    Issitt, P.D., Tegoli, J., Jackson, V., Sanders, C.W. & Allen, F.H. (1968): Anti-IP,: antibodies that show an association between the I and P blood group systems. Vox Sang. 14, 1–8.CrossRefGoogle Scholar
  34. 34.
    ssitt, P.D. (1985): Applied Blood Group Serology. Montgomery Scientific Publications, Miami, FL, USA, 3rd edn., pp 203–218.Google Scholar
  35. 35.
    Jacquinet, J.C. & Sinay, P. (1985): Chemical synthesis of the human Pk-antigenic determinant. Carbohydr. Res. 14, 143–150.CrossRefGoogle Scholar
  36. 36.
    Kannagi, R., Fukuda, M.N. & Hakomori, S.I. (1982): A new glycolipid antigen isolated from human erythrocyte membranes reacting with antibodies directed to globo-N-tetraosylceramide (globoside). J. Biol. Chem. 257, 4438–4442.PubMedGoogle Scholar
  37. 37.
    Kannagi, R., Levine, P., Watanabe, K. & Hakomori, S.I. (1982): Recent studies of glycolipid and glycoprotein profiles and characterization of the major glycolipid antigen in gastric cancer of a patient of blood group genotype pp (Tri first studied in 1951. Cancer Res. 42, 5249–5254.PubMedGoogle Scholar
  38. 38.
    Kannagi, R., Levery, S.B. & Hakomori, S.I. (1983): Sequential change of carbohydrate antigen associated with differentiation of murine leukemia cells: i-I antigenic conversion and shifting of glycolipid synthesis. Proc. Natl. Acad. Sci. USA 80, 2844–2848.PubMedCrossRefGoogle Scholar
  39. 39.
    Kannagi, R., Cochran, N.A., Ishigami, F., Hakomori, S.I., Andrews, P.W., Knowles, B.B. & Softer, D. (1983): Stage-specific embryonic antigens (SSEA-3 and -4) are epitopes of a unique globo-series ganglioside isolated from human teratocarcinoma cells. EMBO J. 2, 2355–2361.PubMedGoogle Scholar
  40. 40.
    Kannagi, R., Levery, S.B., Ishigami, F., Hakomori, S.I., Shevinski, L.H., Knowles, B.B. & Softer, D. (1983): New globoseries glycosphingolipids in human teratocarcinoma reactive with the monoclonal antibody directed to a developmentally regulated antigen, stage-specific embryonic antigen 3. J. Biol. Chem. 258, 8934–8942.PubMedGoogle Scholar
  41. 41.
    Kato, M., Kubo, S. & Naiki, M. (1978): Complement fixation antibodies to glycosphingolipids in sera of rare blood group p and P“ phenotypes. J. Immunogenet. 5, 31–40.PubMedCrossRefGoogle Scholar
  42. 42.
    Kerde, C., Fünfhausen, G., Brunk, R. & Brunk, R. (1960): Über die Gewinnung von hochwertigen Anti-P-Immunseren durch Immunisierung mit Echinokokkenzystenflüssigkeit. Z /mmun.-Forsch. 119, 216–224.Google Scholar
  43. 43.
    Kijimoto-Ochiai, S., Naiki, M. & Makita, A. (1977): Defects of glycosyftransferase activities in human fibroblasts of Pk and p blood group phenotypes. Proc. Nat/. Acad. Sci. USA 74, 5407–5410.CrossRefGoogle Scholar
  44. 44.
    Kortekangas, A.E., Noades, J., Tippett, P., Sander, R. & Race, R.R. (1959): A second family with the red cell antigen Pk. Vox Sang. 4, 337–349.PubMedCrossRefGoogle Scholar
  45. 45.
    Kortekangas, A.E., Kaarsalo, E., Melartin, L, Tippett, P., Gavin, J., Noades, J., Sanger, R. & Race, R.R. (1965): The red cell antigen Pk and its relationship to the P system: the evidence of three more Pk families. Vox Sang. 10, 385–404.PubMedCrossRefGoogle Scholar
  46. 46.
    Koscielak, J., Miller-Podraza, H., Krauze, R. & Cedergren, B. (1976): Glycolipid composition of blood group P erythrocytes. FEBS Leff. 66, 250–253.CrossRefGoogle Scholar
  47. 47.
    Kundu, S.M., Steane, S.M., Bloom, J.E.C. & Marcus, D.M. (1978): Abnormal glycolipid composition of erythrocytes with a weak P-antigen. Vox Sang. 35, 160–167.PubMedCrossRefGoogle Scholar
  48. 48.
    Kundu, S.K., Evans, A., Rizvi, J., Glidden, H. & Marcus, D.M. (1980): A new Pk phenotype in the P blood group system. J. lmmunogenet. 7, 431–439.CrossRefGoogle Scholar
  49. 49.
    Kundu, S.K., Suzuki, A., Sabo, B., McCreary, J., Niver, E., Harman, R. & Marcus, D.M. (1981): Erythrocyte glycosphingolipids of four siblings with the rare blood group p phenotype and their parents. J. lmmunogenet. 8, 357–365.CrossRefGoogle Scholar
  50. 50.
    Kundu, S.K., Marcus, D.M. & Roelcke, D. (1982): Glycosphingolipid receptors for anti-Gd and anti-p cold agglutinins. lmmunol. Lett. 4, 263–267.CrossRefGoogle Scholar
  51. 51.
    Landsteiner, K. & Levine, P. (1927): Further observations on individual differences of human blood. Proc. Soc. Exp. Biol. Med. 24, 941–942.Google Scholar
  52. 52.
    Landsteiner, K. & Levine, P. (1931): The differentiation of a type of human blood by means of normal animal serum. J. lmmuno/. 20, 179–185.Google Scholar
  53. 53.
    Leontein, K., Nilsson, M. & Norberg, T. (1985): Synthesis of the methyl and 1-octyl glycosides of the P-antigen tetrasaccharide (globotetraose). Carbohydr. Res. 144, 231–240.PubMedCrossRefGoogle Scholar
  54. 54.
    Levine, P., Bobbitt, O.B., Waller, R.K. & Kuhmichel, A. (1951): Isoimmunization by a new blood factor in tumor cells. Proc. Soc. Exp. Biol. Med. 77, 403–405.PubMedGoogle Scholar
  55. 55.
    Levine, P. & Koch, E.A. (1954): The rare human isoagglutinin anti-Tj° and habitual abortion. Science 120, 239–241.PubMedCrossRefGoogle Scholar
  56. 56.
    Levine, P., Celano, M. & Staveley, J.M. (1958): The antigenicity of P substance in Echinococcus cyst fluid coated on to tanned red cells. Vox Sang. 3, 434–438.PubMedCrossRefGoogle Scholar
  57. 57.
    Levine, P., Celano, M.J. & Falkowski, F. (1963): The specificity of the antibody in paroxysmal cold hemoglobinuria (P.C.H.). Transfusion 3, 278–280.PubMedCrossRefGoogle Scholar
  58. 58.
    Li, S.C., Kundu, S.K., Degasperi, R. & Li, Y.T. (1986): Accumulation of globotriaosylceramide in a case of leiomyosarcoma. Biochem. J. 240, 925–927.PubMedGoogle Scholar
  59. 59.
    Lingwood, C.A., Law, H., Richardson, S., Petric, M., Brunton, J.L., de Grandis, S. & Karmali, M. (1987): Glycolipid binding of purified and recombinant Escherichia coli produced verotoxin in vitro. J. Biol. Chem. 262, 8834–8839.PubMedGoogle Scholar
  60. 60.
    Lopez, M., Cartron, J., Cartron, J.P., Mariotti, M., Bony, V., Salmon, C. & Levene, C. (1983): Cytotoxicity of anti-PP,Pkantibodies and possible relationship with early abortions of p mothers. Clin. Immunot Immunopathol. 28, 296–303.CrossRefGoogle Scholar
  61. 61.
    Marcus, D.M. (1971): Isolation of a substance with blood-group P, activity from human erythrocyte stroma. Transfusion 11, 16–18.PubMedCrossRefGoogle Scholar
  62. 62.
    Marcus, D.M., Naiki, M. & Kundu, S.K. (1976): Abnormalities in the glycosphingolipid content of human Pk and p erythrocytes. Proc. Natl. Acad. Sci. USA 73, 3263–3267.PubMedCrossRefGoogle Scholar
  63. 63.
    Marcus, D.M., Naiki, M., Kundu, S.K. & Schwarting, G.A. (1977): lmmunochemical studies of the human blood group P system. In: Human Blood Groups, Proceedings of the 5th International Convocation on Immunology, Buffalo 1976 (J.F. Mohn, R.W. Plunkett, R.K. Cunningham & R.M. Lambert eds.), Karger, Basel, pp. 206–215.Google Scholar
  64. 64.
    Marcus, D.M., Kundu, S.K. & Suzuki, A. (1981): The P blood group system: recent progress in immunochemistry and genetics. Sem. Hemetol. 18, 63–71.Google Scholar
  65. 65.
    Matson, G.A., Swanson, J., Noades, J., Sanger, R. & Race, R.R. (1959): A ‘new’ antigen and antibody belonging to the P blood group system. Amer. J. Hum. Genet. 11, 26–34.Google Scholar
  66. 66.
    McAlpine, P.J., Kaita, H. & Lewis, M. (1978): Is the DIA, locus linked to the P blood group locus? Cytogenet. Cell Genet. 22, 629–632.PubMedCrossRefGoogle Scholar
  67. 67.
    Merritt, M. & Hardy, J. (1955): Notes on a serum containing anti-P in high titre. J. Clin Pathol. 8, 329–335.PubMedCrossRefGoogle Scholar
  68. 68.
    Metaxas, M.J., Metaxas-BÜhler, M. & Tippett, P. (1975): A ‘new’ antibody in the P blood group system. XIVth Congress of the International Society of Blood Transfusion, He/sink/ 1975, Finnish Red Cross Blood Transfusion Service, Helsinki, Abstracts p. 95.Google Scholar
  69. 69.
    Morgan, W.T.J. & Watkins, W.M. (1964): Blood group P, substance. I. Chemical properties. Proceedings of the IXth Congress of the International Society of Blood Transfusion, Mexico City 1962, Karger, Basel, pp. 225–229.Google Scholar
  70. 70.
    Naiki, M. & Marcus, D.M. (1974): Human erythrocyte P and Pk blood group antigens: Identification as glycosphingolipids. Biochem. Biophys. Res. Commun. 60, 1105–1111.PubMedCrossRefGoogle Scholar
  71. 71.
    Naiki, M., Fong, J., Ledeen, R. & Marcus, D.M. (1975): Structure of the human erythrocyte blood group P, glycosphingolipid. Biochemistry 14, 4831–4837.PubMedCrossRefGoogle Scholar
  72. 72.
    Naiki, M. & Marcus, D.M. (1975): An immunochemical study of the human blood group P„ P and Pk glycosphingolipid antigens. Biochemistry 14, 4837–4841.PubMedCrossRefGoogle Scholar
  73. 73.
    Naiki, M. & Kato, M. (1979): Immunological identification of blood group Pk antigen on normal human erythrocytes and isolation of anti-Pk with different affinity. Vox Sang. 37, 30–38.PubMedCrossRefGoogle Scholar
  74. 74.
    Nudelman, E., Kannagi, R., Hakomori, S.I., Parsons, M., Lipinski, M., Wiels, J., Fellous, M. & Tursz, T. (1983): A glycolipid antigen associated with Burkitt lymphoma defined by a monoclonal antibody. Science 220, 509–511.PubMedCrossRefGoogle Scholar
  75. 75.
    Obrig, T.G., Louise, C.B., Lingwood, C.A., Boyd, B., Barley-Maloney, L & Daniel, T.O. (1993): Endothelial heterogeneity in Shiga toxin receptors and responses. J. Biol. Chem. 268, 15484–15488.Google Scholar
  76. 76.
    Paulsen, H. & Bünsch, A. (1982): Synthese der Tetrasaccharid-Kette des P-Antigen-Globosids. Eine ß-D-Glycosidsynthese für 2-Amino-2-Desoxyzucker. Carbohydr. Res. 101, 21–30.CrossRefGoogle Scholar
  77. 77.
    Poppe, L, Dabrowski, J., von der Lieth, C.W., Koike, K. & Ogawa, T. (1990): Three-dimensional structure of the oligosaccharide terminus of globotriaosylceramide and isoglobotriaosylceramide in solution. A rotating-frame NOE study using hydroxyl groups as long-range sensors in conformational analysis by ‘H-NMR spectroscopy. Eur. J. Brachem. 189, 313–325.CrossRefGoogle Scholar
  78. 78.
    Poppe, L. von der Ueth, C.W., & Dabrowski, J. (1990): Conformations of the glycolipid globoside head group in various solvents and in the micells-bound state. J. Amer. Chem. Soc. 112, 7762–7771.CrossRefGoogle Scholar
  79. 79.
    Prokop, O. & Schlesinger, D. (1965): Ober das Vorkommen von P, Blutgruppensubstanz in Ascaris suum. Dtsch. Gesundh. Wes. 1584.Google Scholar
  80. 80.
    Prokop, O. & Schlesinger, D. (1965): Ober das Vorkommen von P, Blutgruppensubstanz oder einer ‘P,-like-substance’ bei Lumbricus terrestris. Acta Biol. Med. Germ. 15, 180–181.Google Scholar
  81. 81.
    Race, R.R. & Sanger, R. (1975): The P-blood groups. In: Blood Groups in Man (Blackwell Scientific Publications, Oxford), 6th edn., pp. 139–177.Google Scholar
  82. 82.
    Sanger, R. (1955): An association between the P and Jay systems of blood groups. Nature 176, 1163–1164.PubMedCrossRefGoogle Scholar
  83. 83.
    Schnitzler, S., Moller, G. & Prokop, O. (1967): Ein ‘neuer’ Antikörper: Anti-Pm, aufgefunden im Rogen von Rutilus rutilus. Z Immun-Forsch. 134, 45–53.Google Scholar
  84. 84.
    Schwarting, G.A., Marcus, D.M. & Metaxas, M. (1977): Identification of sialosylparagloboside as an erythrocyte receptor for an ‘anti-p’ antibody. Vox Sang. 32, 257–261.PubMedCrossRefGoogle Scholar
  85. 85.
    Schwarting, G.A., Kundu, S.K. & Marcus, D.M. (1979): Reaction of antibodies that cause paroxysmal cold hemoglobinuria (PCH) with globoside and Forssman glycosphingolipid. Blood 53, 186–192.PubMedGoogle Scholar
  86. 86.
    SBderstrbm, T., Enskog, A., Samuelsson, B.E. & Cedergren, B. (1985): Immunoglobulin subclass (IgG3) restriction of anti-P and anti-Pk antibodies in patients of the rare p blood group. J. Immunof. 134, 1–3.Google Scholar
  87. 87.
    Staveley, J.M. & Cameron, G.L. (1958): The inhibiting action of hydatid cyst fluid on anti-Tj° sera. Vox Sang. 3, 114–118.PubMedCrossRefGoogle Scholar
  88. 88.
    Takeya, k, Hosomi, O., Shimoda, N. & Yazawa, S. (1992): Biosynthesis of the blood group P antigen-like GaINAc01—(3Gal131—>4GIcNAc/Glc structure: a novel N-acetylgalactosaminytransferase in human plasma. J. Biochem. 112, 389–395.PubMedGoogle Scholar
  89. 89.
    Taniguchi, N. & Makita, A. (1984): Purification and characterization of UDP-N-acetylgalactosamine: globotriaosylceramide 13–3-N-acetylgalactosaminyltransferase, a synthase of human blood group P antigen, from canine spleen. J. Biol. Chem. 259, 5637–5642.PubMedGoogle Scholar
  90. 90.
    Taniguchi, N., Yanagisawa, K., Makita, A. & Naiki, M. (1985): Purification and properties of rat liver globotriaosylceramide synthase, UDP-galactose:lactosylceramide al -4-galactosyltransferase. J. Biol. Chem. 260, 4908–4913.PubMedGoogle Scholar
  91. 91.
    Thorn, J.J., Levery, S.B., Salyan, M.E.K., Stroud, M.R., Cedergren, B., Nilsson, B., Hakomori, S.I. & Clausen, H. (1992): Structural characterization of xZ glycosphingolipid, its extended form, and its sialosyl derivatives: accumulation associated with the rare blood group p phenotype. Biochemistry 31, 6509–6517.PubMedCrossRefGoogle Scholar
  92. 92.
    Tippett, P., Sanger, R., Race, R.R., Swanson, J. & Bush, S. (1965): An agglutinin associated with the P and the ABO blood group system. Vox Sang. 10, 269–280.PubMedCrossRefGoogle Scholar
  93. 93.
    Tippett, P., Andrews, P.W., Knowles, B.B., Softer, D. & Goodfellow, P.N. (1986): Red cell antigens P (globoside) and Luke: Identification by monoclonal antibodies defining the murine stage-specific embryonic antigens-3 and -4 (SSEA-3 and SSEA-4). Vox Sang. 51, 53–56.PubMedCrossRefGoogle Scholar
  94. 94.
    Tonegawa, Y. & Hakomori, S.I. (1977): ‘Ganglioprotein and globoprotein’: The glycoproteins reacting with anti-ganglioside and anti-globoside antibodies and the ganglioprotein change associated with transformation. Biochem. Biophys. Res. Commun. 76, 9–17.Google Scholar
  95. 95.
    Vance, D.E. & Sweeley, C.C. (1967): Quantitative determination of the neutral glycosyl ceramides in human blood. J. Lipid Res. 8, 621–630.PubMedGoogle Scholar
  96. 96.
    Voak, D., Anstee, D.J. & Pardoe, G. (1973): The a-galactose specificity of anti-Pk. Vox Sang. 25, 263–270.PubMedCrossRefGoogle Scholar
  97. 97.
    Voak, D., Todd, G.M. & Pardoe, G.I. (1974): A study of the serological behaviour and nature of the anti-B/P/Pk activity of Salmonidae roe protectin. Vox Sang. 26, 176–188.PubMedCrossRefGoogle Scholar
  98. 98.
    Von dem Borne, A.E.G.K., Bos, M.J.E., Joustra-Maas, N., Tromp, J.F., van Wijngaarden–du Bois, R. & Tetteroo, P.A.T. (1986): A murine monoclonal IgM antibody specific for blood group P antigen (globoside). Brit. J. Haematol. 63, 35–46.CrossRefGoogle Scholar
  99. 99.
    Walsh, R.J. & Kooptzoff, O. (1954): The human blood group Tj“. Aust. J. Exp. Biol. Med. Sci 32, 387–392.PubMedCrossRefGoogle Scholar
  100. 100.
    Watkins, W.M. & Morgan, W.T.J. (1964): Blood-group P, substance. Il. Immunological properties. Proceedings of the IXth Congress of the International Society of Blood Transfusion, Mexico City 1962, Karger, Basel, pp. 230–234.Google Scholar
  101. 101.
    Wiels, J., Fellous, M. &Tursz, T. (1981): Monoclonal antibody against a Burkitt lymphoma-associated antigen. Proc. Natl. Acad. Sci. USA 78, 6485–6488.PubMedCrossRefGoogle Scholar
  102. 102.
    Worlledge, S.M. & Rousso, C. (1965): Studies on the serology of paroxysmal cold haemoglobinuria (P.C.H.), with special reference to its relationship with the P blood group system. Vox Sang. 10, 293–298.PubMedCrossRefGoogle Scholar
  103. 103.
    Yamasaki„ R., Bacon, B.E., Nasholds, W., Schneider, H. & Griffiss, J.M. (1991): Structural determination of oligosaccharides derived from lipooligosaccharide of Neisseria gonorrhoeae F62 by chemical, enzymatic, and two-dimensional NMR methods. Biochemistry 30, 10566–10575.PubMedCrossRefGoogle Scholar
  104. 104.
    Yates, A.D., Donald, A.S.R., Watkins, W.M. & Morgan, W.T.J. (1975): Immunochemical observations on the human blood group P system. XlVth Congress of the International Society of Blood Transfusion, Helsink; 1975, Finnish Red Cross Blood Transfusion Service, Helsinki, Abstract p. 95.Google Scholar
  105. 105.
    Yates, A.D., Morgan, W.T.J. & Watkins, W.M. (1975): Linkage-specific a-D-galactosidases from Trichomonas foetus: Characterization of the blood-group B-destroying enzyme as a 1,3-a-galactosidase and the blood group P,-destroying enzyme as a 1,4-a-galactosidase. FEBS Left. 60, 281–285.CrossRefGoogle Scholar
  106. 106.
    Zollo, P.H.A., Jacquinet, J.C. & Sinai’, P. (1983): Chemical synthesis of the human blood-group P1-antigenic determinant. Carbohydr. Res. 122, 201–208.CrossRefGoogle Scholar
  107. 107.
    Zoutendyk, A. & Levine, P. (1952): A second example of the rare serum anti-Jay (Tj°). Amer. J. Clin. Path. 22, 630–633.Google Scholar

Copyright information

© Springer-Verlag Wien 1995

Authors and Affiliations

  • Helmut Schenkel-Brunner
    • 1
  1. 1.Institut für BiochemieUniversität WienViennaAustria

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