The Antigens of the Major Histocompatibility Complex (HLA Antigens)

  • Helmut Schenkel-Brunner


The HLA (= ’Human Leucocyte antigen locus A’) antigens are transmitted by a group of genes representing the Major Histocompatibility Complex (= MHC) of humans.


Major Histocompatibility Complex Histocompatibility Antigen Antigen Binding Site Human Major Histocompatibility Complex Antigen Recognition Site 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Bjorkman, P.J., Saper, M.A., Samraoui, B., Bennett, W.S., Strominger, J.L. & Wiley, D.C. (1987): Structure of the human class I histocompatibility antigen, HLA-A2. Nature 329, 506–512.PubMedCrossRefGoogle Scholar
  2. 2.
    Bjorkman, P.J., Saper, M.A., Samraoui, B., Bennett, W.S., Strominger, J.L. & Wiley, D.C. (1987): The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens. Nature 329, 512–518.PubMedCrossRefGoogle Scholar
  3. 3.
    Bjorkman, P.J. & Parham, P. (1990): Structure, function, and diversity of class I major histocompatibility complex molecules. Annu. Rev. Biochem. 59, 253–288.PubMedCrossRefGoogle Scholar
  4. 4.
    Bodmer, J.G., Marsh, S.G.E., Albert, E.D., Bodmer, W.F., Dupont, B., Erlich, H.A., Mach, B., Mayr, W.R., Parham, P., Sasazuki, T., Schreuder, G.M.T., Strominger, J.L., Svejgaard, A. & Terasaki, P.I. (1994): Nomenclature for factors of the HLA system, 1994. Tissue Antigens 44, 1–18.PubMedCrossRefGoogle Scholar
  5. 5.
    Brown, J.H., Jardetzky, T.S., Gorga, J.C., Stern, L.J., Urban, R.G., Strominger, J.L. & Wiley, D.C. (1993): Three-dimensional structure of the human class Il histocompatibility antigen HLA-DR1. Nature 364, 33–39.CrossRefGoogle Scholar
  6. 6.
    Colombani, J. (1990): Conserved and variable structures in HLA class I molecules: a review. Tissue Antigens 35, 103–113.PubMedCrossRefGoogle Scholar
  7. 7.
    Dupont, B. (1989): Immunobiology of HLA (Vols. I and I I). Springer, New York — Berlin — Heidelberg.CrossRefGoogle Scholar
  8. 8.
    Garrett, T.P.J., Saper, M.A., Bjorkman, P.J., Strominger, J.L. & Wiley, D.C. (1989): Specificity pockets for the side chains of peptide antigens in HLA-Aw68. Nature 342, 692–696.PubMedCrossRefGoogle Scholar
  9. 9.
    Goodfellow, P.N., Jones, E.A., van Hayningen, V., Solomon, E., Bobrow, M., Miggiano, V. & Bodmer, W.F. (1975): The β2 microglobulin gene is on chromosome 15 and not in the HLA region. Nature 254,267–269.PubMedCrossRefGoogle Scholar
  10. 10.
    Gorga, J.C. (1992): Structural analysis of class II major histocompatibility complex proteins. Crit. Rev. immunoi. 11, 305–335.Google Scholar
  11. 11.
    Kappes, D. & Strominger, J.L. (1988): Human class II major histocompatibility complex genes and proteins. Annu. Rev. Biochem. 57, 991–1128.PubMedCrossRefGoogle Scholar
  12. 12.
    Kaufman, J.F., Auffray, C., Korman, A.J., Shackelford, D.A. & Strominger, J. (1984): The class II molecules of the human and murine major histocompatibility complex. Cell 36, 1–13.PubMedCrossRefGoogle Scholar
  13. 13.
    Kennedy, L.J., Marsh, S.G.E. & Bodmer, J. (1987): Cytotoxic monoclonal antibodies. In: ImmunobiologyofHLA. Vol. I. Histocompatibility testing 1987. ( B. Dupont, ed.), Springer Verlag, Berlin, pp. 301–305.Google Scholar
  14. 14.
    Mayr, W.R. (1988): Das HLA-System. In: Transfusionsmedizin ( C. Mueller-Eckhardt, ed.), Springer Verlag, Berlin-Heidelberg-New York, pp. 173–193.Google Scholar
  15. 15.
    Mayr, W.R. (1989): HLA polymorphisms. In: Two-dimensional electrophoresis. Proceedings of the International Two-Dimensional Electrophoresis Conference, Vienna, Nov. 1988. (A.T. Endler & S. Hanash, eds.), pp. 112–119.Google Scholar
  16. 16.
    Mayr, W.R. (1990): HLA 1990. Blut 61, 207–212.PubMedCrossRefGoogle Scholar
  17. 17.
    Marsh, S.G.E. & Bodmer, J.G. (1989): HLA-DR and -DQ epitopes and monoclonal antibody specificity. Immunology Today 10, 305–312.PubMedCrossRefGoogle Scholar
  18. 18.
    Nakamuro, K., Tanigaki, N. & Pressman, D. (1973): Multiple common properties of human 132 microglobulin and the common portion fragment derived from HL-A antigen molecules. Proc. Natl. Acad. Sci. U.S.A. 70, 2863–2865.PubMedCrossRefGoogle Scholar
  19. 19.
    Nelson, K., Bodmer, J., Martin, A., Navarette, C.G. & Strong, D.M. (1987): Micro EIA and monoclonal antibodies. In: Immunobiologyof HLA. VoL. I. Histocompatibiity Testing 1987. ( B. Dupont, ed.), Springer Verlag, Berlin, pp. 292–301.Google Scholar
  20. 20.
    Saper, M.A., Bjorkman, P.J. & Wiley, D.C. (1991): Refined structure of the human histocompatibility antigen HLA-A2 at 2.6 A resolution. J. Mol. Biol. 219, 277–319.PubMedCrossRefGoogle Scholar
  21. 21.
    Trowsdale, J., Ragoussis, J. & Campbell, R.D. (1991): Map of the human MHC. Immunology Today 12, 443–446.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Wien 1995

Authors and Affiliations

  • Helmut Schenkel-Brunner
    • 1
  1. 1.Institut für BiochemieUniversität WienViennaAustria

Personalised recommendations