Colton System

  • Helmut Schenkel-Brunner


In the Colton blood group system thus far three specificities are defined, viz. Co a [3], its antithetical antigen Co b [2], and Co ab (= Co3), a specificity common to Co a and Co b [10](1).


Blood Group Blood Group Antigen Membrane Topology Human Blood Group Ancient Channel 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Agre, P., Preston, G.M., Smith, B.L., Jung, J.S., Raina, S., Moon, C., Guggino, W.B. & Nielsen, S. (1993): Aquaporin CHIP: the archetypal molecular water channel. Amer. J. Physiol. 265, F463–76PubMedGoogle Scholar
  2. 2.
    Giles, C.M., Darnborough, J., Aspinall, P. & Fletton, M.W. (1970): Identification of the first example of anti-Cob. Brit. J. Haematoi. 19, 267–269.CrossRefGoogle Scholar
  3. 3.
    Heistó, H., van der Hart, M., Madsen, GF., Moes, M., Noades, J., Pickles, M.M., Race, R.R., Sanger, R. & Swanson, J. (1967): Three examples of a new red cell antibody, anti-Coa. Vox Sang. 12, 18–24.CrossRefGoogle Scholar
  4. 4.
    Moon, C., Preston, G.M., Griffin, C., Jabs, E.W. & Agre, P. (1993): The human aquaporin CHIP gene: structure, organization, and chromosomal localization. J. Biol. Chem. 268, 15772–15778.PubMedGoogle Scholar
  5. 5.
    Nielsen, S., Smith, B.L., Christensen, E.I. & Agre, P. (1993): Distribution of the aquaporin CHIP in secretory and resorptive epithelia and capillary endothelia. Proc. Natl. Acad. Sol. USA 90, 7275–7279.CrossRefGoogle Scholar
  6. 6.
    Preston, G.M. & Agre, P. (1991): Molecular cloning of the red cell integral membrane protein of M, 28,000: a member of an ancient channel family. Proc. Nati. Acad. Sci. USA 88, 11110–11114.CrossRefGoogle Scholar
  7. 7.
    Preston, G.M., Jung, J.S., Guggino, W.B. & Agre, P. (1994): Membrane topology of aquaporin CHIP. Analysis of functional epitope-scanning mutants by vectorial proteolysis. J. Biol. Chem. 269, 1668–1673.PubMedGoogle Scholar
  8. 8.
    Preston, G.M., Smith, B.L., Zeidel, M.L., Moulds, J.J. & Agre, P. (1994): Mutations in aquaporin-1 in phenotypically normal humans without functional CHIP water channels. Science 265, 1585–1587.PubMedCrossRefGoogle Scholar
  9. 9.
    Race, R.R. & Sanger, R. (1975): The Colton blood groups. In: Blood Groups in Man. Blackwell Scientific Publications, Oxford, 6th edn., pp. 391–394.Google Scholar
  10. 10.
    Rogers, M.J., Stiles, P.A. & Wright, J. (1974): A new minus-minus phenotype: three Co(a-b-) individuals in one family. Transfusion 14, 508 (Abstract).Google Scholar
  11. 11.
    Smith, B.L. & Agre, P. (1991): Erythrocyte Mr 28,000 transmembrane protein exists as a multisubunit oligomer similar to channel proteins. J. Bioi. Chem. 266, 6407–6415.Google Scholar
  12. 12.
    Smith, B.L., Preston, G.M., Spring, F.A., Anstee, D.J. & Agre, P. (1994): Human red cell aquaporin CHIP. I. Molecular characterization of ABH and Colton blood group antigens. J. Clín. Invest. 94, 1043–1049.PubMedCrossRefGoogle Scholar
  13. 13.
    Zelinski, T.H., Kaita, T. Gilson, G., Coghlan, S., Philipps, S. & Lewis, M. (1990): Linkage between the Colton blood group locus and ASSP11 on chromosome 7. Genomics 6, 623–625.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Wien 1995

Authors and Affiliations

  • Helmut Schenkel-Brunner
    • 1
  1. 1.Institut für BiochemieUniversität WienViennaAustria

Personalised recommendations