Ina and Inb

  • Helmut Schenkel-Brunner


The antigen collection ’Indian’ comprises two specificities, In a and In b(1). The In a antigen which is extremely rare in Europids but is found in 2–4% of the Indian population has been described by Badakere et al. [1]. The antithetical antigen In b , a common character in Europids, has been defined by Giles; it was found to be identical to the antigen originally specified by the serum ’Salis’ [8].


CD44 Protein High Endothelial Venule Neuraminic Acid Lymph Node Homing Lymphocyte Homing 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Badakere, S.S., Parab, B.B. & Bhatia, H.M. (1974): Further observations on the In° (Indian) antigen in Indian populations. Vox Sang. 26, 400–403.Google Scholar
  2. 2.
    Cobbold, S., Hale, G. & Waldmann, H. (1987): Non-lineage, LFA-1 family, and leucocyte common antigens: new and previously defined clusters. In: Leucocyte typing III: White Cell Differentiation Antigens, (A. J. McMichael et al., eds.), Oxford University Press, Oxford p. 788.Google Scholar
  3. 3.
    Dalchau, R., Kirkley, J. & Fabre, J.W. (1980): Monoclonal antibody to a human brain-granulocyte-T-lymphocyte antigen probably homologous to the W3113 antigen of the rat. Eur. J. fmmunof. 10, 745–749.Google Scholar
  4. 4.
    Doege, K., Sasaki, M., Horigan, E, Hassell, J. R. & Yamada, Y. (1987): Complete primary structure of the rat cartilage proteoglycan core protein deduced from cDNA clones. J. Biol. Chem. 262, 17757–17767.Google Scholar
  5. 5.
    Dougherty, G.J., Lansdorp, P.M., Cooper, D.L. & Humphries, R.K. (1991): Molecular cloning of CD44R1 and CD44R2, two novel isoforms of the human CD44 lymphocyte “homing” receptor expressed by hemopoietic cells. J. Exp. Med. 174, 1–5.Google Scholar
  6. 6.
    Ferguson, D.J. & Gall, H.D. (1988): Some observations on the Inb antigen and evidence that anti-Inb causes accelerated destruction of radiolabeled red cells. Transfusion 28, 479–482.PubMedCrossRefGoogle Scholar
  7. 7.
    Francke, U., Foellmer, B.F. & Haynes, B.F. (1983): Chromosome mapping of human cell surface molecules: monoclonal anti-human lymphocyte antibodies 4F2, A3D8, and A1G3 define antigens controlled by different regions of chromosome 11. Som. Cell Genet. 9, 333–344.Google Scholar
  8. 8.
    Giles, C.M. (1975): Antithetical relationship of anti-ln° with the Salis antibody. Vox Sang. 29, 73–78.PubMedCrossRefGoogle Scholar
  9. 9.
    Goldstein, L.A., Zhou, D.F.H., Picker, L.J., Minty, C.N., Bargatze, R.F., Ding, J. F. & Butcher, E.C. (1989): A human lymphocyte homing receptor, the Hermes antigen, is related to cartilage proteoglycan core and link proteins. Cell 56, 1063–1072.Google Scholar
  10. 10.
    Goodfellow, P.N., Banting, G., Wiles, M.V., Tunnacliffe, A., Parker, M., Solomon, E., Dalchau, R. & Fabre, J.W. (1982): The gene MIC4, which controls expression of the antigen defined by monoclonal antibody F 10.44.2, is on human chromosome 11. Eur. J. lmmuno/. 12, 659–663.Google Scholar
  11. 11.
    Herrlich, P., ZSller, M., Pals, S.T. & Ponta, H. (1993): CD44 splice variants: metastases meet lymphocytes. Immunology Today 14, 395–399.CrossRefGoogle Scholar
  12. 12.
    lsacke, C.M., Sauvage, C.A., Hyman, R., Lesley, J., Schulte, R. & Trowbridge, I.S. (1986): Identification and characterization of the human Pgp-1 glycoprotein. Immunogenetics 23, 326–331.Google Scholar
  13. 13.
    Jackson, D.G., Buckley, J. & Bell, J.I. (1992): Multiple variants of the human lymphocyte homing receptor CD44 generated by insertions at a single site in the extracellular domain. J. Biol. Chem. 267, 4732–4739.Google Scholar
  14. 14.
    Jalkanen, S., Bargatze, R.F., Herron, L.R. & Butcher, E.C. (1986): A lymphoid cell surface glycoprotein involved in endothelial cell recognition and lymphocyte homing in man. Eur. J. fmmunof. 16, 1195–1202.Google Scholar
  15. 15.
    Jalkanen, S., Reichert, R.A., Gallatin, W.M, Bargatze, R.F, Weissman, I.L. & Butcher, E.C. (1986): Homing receptors and the control of lymphocyte migration. lmmuno% Rev. 91, 39–60.Google Scholar
  16. 16.
    Jalkanen, S., Bargatze, R.F., de los Toyos, J. & Butcher, E.C. (1987): Lymphocyte recognition of high endothelium: antibodies to distinct epitopes of an 85–95kD glycoprotein antigen differentially inhibit lymphocyte binding to lymph node, mucosal, or synovial endothelial cells. J. Cell Biol. 105, 983–990.PubMedCrossRefGoogle Scholar
  17. 17.
    Jalkanen, S., Jalkanen, M., Bargatze, R.F, Tammi, M. & Butcher, E.C. (1988): Biochemical properties of glycoproteins involved in lymphocte recognition of high endothelial venules in man. J. /mmuno% 141, 1615–1623.Google Scholar
  18. 18.
    Letarte, M., Iturbe, S. & Quackenbusch, E.J. (1985): A glycoprotein of molecular weight 85,000 on human cells of B-lineage: detection with a family of monoclonal antibodies. Molec. fmmunof. 22, 113–118.Google Scholar
  19. 19.
    Lewinsohn, D.M., Bargatze, R.F. & Butcher, E.C. (1987): Leukocyte-endothelial cell recognition: evidence of a common molecular mechanism shared by neutrophils, lymphocytes, and other leukocytes. J. fmmunof. 138, 4313–4321.Google Scholar
  20. 20.
    Neame, P.J., Christner, J.E. & Baker, J.R. (1987): The link protein and proteoglycan amino-terminal globularGoogle Scholar
  21. domains have similar structures. J. Biol. Chem. 262,17768–17778.Google Scholar
  22. 21.
    Pals, S.T., Hogervorst, F., Keizer, G.D., Thepen, T., Horst, E. & Figdor, C.C. (1989): Identification of a widely distributed 90-kDa glycoprotein that is homologous to the Hermes-1 human lymphocyte homing receptor. J. lmmuno% 143, 851–857.Google Scholar
  23. 22.
    Picker, L.J., Nakache, M. & Butcher, E.C. (1989): Monoclonal antibodies to human lymphocyte homing receptors define a novel class of adhesion molecules on diverse cell types. J. Cell Biol. 109, 927–937.Google Scholar
  24. 23.
    Quackenbush, E.J., Gougos, A., Baumal, R. & Letarte, M. (1986): Differential localisation within human kidney of five membrane proteins expressed on acute lymphoblastic leukaemia cells. J. lmmuno% 136, 118–124.Google Scholar
  25. 24.
    Screaton, G.R., Bell, M.V., Jackson, D.G., Cornelis, F.B., Gerth, U. & Bell, J.I. (1992): Genomic structure of DNA encoding the lymphocyte homing receptor CD44 reveals at least 12 alternatively spliced exons. Proc. Natl. Acad. Seg. USA 89, 12160–12164.Google Scholar
  26. 25.
    Spring, F.A., Dalchau, R., Daniels, G.L., Mallinson, G., Judson, P.A., Parsons, S.F., Fabre, J.W. & Anstee, D.J. (1988): The Ina and In° blood group antigens are located on a glycoprotein of 80,000 MW (the CDw44 glycoprotein) whose expression is influenced by the In(Lu) gene. Immunology 64, 37 – 43.Google Scholar
  27. 26.
    Stamenkovic, I., Amiot, M., Pesandro, J. & Seed, B. (1989): A lymphocyte molecule implicated in lymph node homing is a member of the cartilage link protein family. Cell 56, 1057–1063.Google Scholar
  28. 27.
    Stamenkovic, I., Aruffo, A., Amiot, M. & Seed, B. (1991): The hematopoietic and epithelial forms of CD44 are distinct polypeptides with different adhesion potentials for hyaluronate-bearing cells. EMBO J.10, 343–348.Google Scholar
  29. 28.
    Stamper, H.B. & Woddruff, J.J. (1976): Lymphocyte homing into lymph nodes: in vitro demonstration of the selective affinity of recirculating lymphocytes for high endothelial venules. J. Exp. Med. 144, 828–833.Google Scholar
  30. 29.
    Telen, M.J., Palker, T.J. & Haynes, B.F. (1984): Human erythrocyte antigens. Il. The In(Lu) gene regulates expression of an antigen on an 80-kilodahon protein of human erythrocytes. Blood 64, 599–606.Google Scholar
  31. 30.
    Telen, M.J., Shehata, H. & Haynes, B.F. (1986): Human medullary thymocyte p80 antigen and In(Lu)-related p80 antigen reside on the same protein. Hum. lmmuno% 17, 311–324.Google Scholar
  32. 31.
    Talg, C., Hofmann, M., Herrlich, P. & Ponta, H. (1993): Splicing choice from ten variant exons establishes CD44 variability. Nucl. Acids. Fees. 21, 1225 – 1229.Google Scholar

Copyright information

© Springer-Verlag Wien 1995

Authors and Affiliations

  • Helmut Schenkel-Brunner
    • 1
  1. 1.Institut für BiochemieUniversität WienViennaAustria

Personalised recommendations