Rh System

  • Helmut Schenkel-Brunner


In 1939, Levine and Stetson [64] first assumed that serological incompatibility between mother and child was the cause of erythroblastosis foetalis, or haemolytic disease of the newborn (HDN). The authors found that a maternal antibody entering the foetal circulation leads to destruction of foetal erythrocytes. One year later, Wiener and Peters [113] were able to identify the same antibody in the serum of individuals showing transfusion reactions after ABO-compatible blood transfusions. In 1941, Levine et al. [65] reported that the antibody responsible for this disease had the same specificity as the anti-Rhesus antibody obtained by Landsteiner and Wiener [59,60] after injecting rabbits and guinea pigs with erythrocytes of rhesus monkeys.


Blood Group Erythrocyte Membrane Human Erythrocyte Membrane Blood Group System Human Blood Group 
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Copyright information

© Springer-Verlag Wien 1995

Authors and Affiliations

  • Helmut Schenkel-Brunner
    • 1
  1. 1.Institut für BiochemieUniversität WienViennaAustria

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