Sialic Acid-Containing Receptors for Cold Agglutinins

  • Helmut Schenkel-Brunner


Various cold agglutinins which react with sialic acid-dependent antigens of the red cell membrane have been described in human sera. Seven specificities have been defined to date: Pr [20], Gd [26], Sa [27], FI [28], Lud [29], Vo [33], and Li [35]. They are characterised as follows: the Pr antigen is completely destroyed by protease-treatment of the erythrocytes, whereas Sa and Lud are only partially degraded, and Gd, FI, Vo, and Li are protease-resistant. The occurrence of Pr, Gd, and Sa is independent of age; the antigens FI and Lud are fully expressed only on the red cells of adults; Vo and Li are present primarily on erythrocytes of newborns, but can also be found on i adult cells. All these serological properties are destroyed by neuraminidase, thus confirming the role of neuraminic acid as the immunodominant component. The characteristics of these antigens are summarised in Tab. 12.1.


Sialic Acid Erythrocyte Membrane Mycoplasma Pneumoniae Oligosaccharide Chain Cold Agglutinin 
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Copyright information

© Springer-Verlag Wien 1995

Authors and Affiliations

  • Helmut Schenkel-Brunner
    • 1
  1. 1.Institut für BiochemieUniversität WienViennaAustria

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