In dogs subjected to incremental doses of morphine up to 1.2 mg/kg a progressive decrease of CMRO2 and CBF to 85% and 45% of control has been found. A single dose of morphine 2 mg/kg had the same effect. These effects were reversed by pain stimulation (Kuramoto et al. 1979) and nalorphine, which initially produce an overshoot in both CBF and CMRO2 (Takeshita et al. 1972). Compatible with these results, CSF pressure is unchanged when morphine is administered to artificially ventilated dogs, but under these circumstances nalorphine increases CSF pressure (Weitzner et al. 1963).
KeywordsNitrous Oxide Spinal Cord Blood Flow Fentanyl Anaesthesia High Dose Fentanyl Traumatic Coma
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