During the last decade, the effects of anaesthetics on cerebral blood flow (CBF), cerebral metabolic rate of oxygen (CMRO2) and intracranial pressure (ICP) have been studied experimentally and clinically, and several reviews have been published (Lassen and Christensen 1976, Frost 1984, Messick et al. 1985, Shapiro 1986). However, deductions concerning the effects of anaesthetics of cerebral circulation and metabolism, and the clinical applications of anaesthetics in neurosurgical practice are primarily based on experimental studies. One reason for this dilemma is, that clinical studies of CBF and metabolism during neuroanaesthesia is difficult because flow detectors have to be placed within the operative field.


Cerebral Blood Flow Nitrous Oxide Operative Field Blocking Agent Neuromuscular Blockade 
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© Springer-Verlag Wien 1990

Authors and Affiliations

  • Jörn Bo Madsen
    • 1
  • Georg Emil Cold
    • 2
  1. 1.Department of AnaesthesiologyCopenhagen County Hospital at HvidovreHvidovreDenmark
  2. 2.Department of NeuroanaesthesiologyÅrhus KommunehospitalÅrhusDenmark

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