Unusual Stabilities of the Pyruvate-Glycinate Mixed Complexes with Some Divalent Metal Ions
Transamination between oxo- and amino-acids is one of the enzymatic reactions that can be duplicated in metal ion model systems (1–4). The reactive intermediates appear to be “mixed” complexes in which it is thought the ligands are condensed as Schiff bases. Recently, ways of applying pH- titration techniques to these systems and analyzing the data using high speed computers have been proposed (5). This earlier study (5) which concerned the Ni(II)-pyruvate-glycinate system has been extended to an examination of the Ca(II), Mn(II) and Zn(II) systems at 25°. An attempt was also made to obtain the heats and entropies of formation of the Mn(II), Ni(II) and Zn(II) complexes from additional titrimetric data at 10 and 40°.
KeywordsSchiff Base Pyruvic Acid Sodium Methoxide Mixed Complex High Speed Computer
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