Abstract
The biological phenomenon of“sleep” is an instinctual action, an active process, which represents an energy-restoring function for the organism, and which is entirely governed by the mid-brain. W. R. Hess showed in animal experiments that cats whose mid-brain region was electrically stimulated fell asleep, and Jouvet succeeded in isolating the putative neurotransmitter responsible for releasing sleep: it turned out to be serotonin (5-HT). He was also able to show that para-chlorophenylalanine, an antagonist of 5-HT-synthesis, could stop an animal from falling asleep. The precursors tryptophan and 5-hydroxytryptophan, both of which can cross the bloodbrain-barrier (see Fig. 2), are converted to serotonin in the nerve cell. Release of the neurotransmitter then induces sleep. The switching off of the conscious waking state goes hand in hand with a total biological transformation of the whole organism: the phase of sympathetic performance which is maintained by the transmitter noradrenaline (NA) is replaced by the energy-restoring recovery phase: blood-pressure is lowered, the pulse is slowed, breathing becomes shallower and the painthreshold is raised.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 1989 Springer-Verlag Wien
About this chapter
Cite this chapter
Birkmayer, W., Riederer, P. (1989). Sleep. In: Understanding the Neurotransmitters: Key to the Workings of the Brain. Springer, Vienna. https://doi.org/10.1007/978-3-7091-3451-1_4
Download citation
DOI: https://doi.org/10.1007/978-3-7091-3451-1_4
Publisher Name: Springer, Vienna
Print ISBN: 978-3-211-82100-8
Online ISBN: 978-3-7091-3451-1
eBook Packages: Springer Book Archive