Abstract
Infectious diseases remain the preeminent health problems in the developing world, and immunization the most effective approach to controlling them. Recombinant DNA technology has provided a plethora of new approaches for the development of vaccines. The priorities for development of new vaccines and delivery methods have been redefined by the Children’s Vaccine Initiative. Among the diseases targeted for vaccine improvement or development are three arbovirus infections, dengue, Japanese encephalitis, and yellow fever. The burden of disease caused by these mosquito-borne viruses, the current status of classical vaccines, and progress toward development of genetically-engineered vaccines are reviewed. Since 1984, the World Health Organization has promulgated research leading toward the development of molecular approaches to vaccines against these flaviviruses. Considerable headway has been made in the understanding of genome variation, the identification of protective epitopes, and in cloning and expression of relevant proteins in vaccinia and baculovirus systems. In addition, the development of full-length complementary DNA clones which yield infectious RNA transcripts is being pursued as a means of producing stable, attenuated and chimeric flavivirus vaccines.
Chapter PDF
Similar content being viewed by others
Keywords
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
References
Henderson RH, Keja J (1989) Global control of vaccine-preventable diseases: how progress can be evaluated. Rev Infect Dis 11: 649
Nakajima H (1990) Epidemiology and the future of the world. PAHO Epidemiol Bull 11 :1
Bektimirov T, Lambert P-H, Torrigiani G (1990) Vaccine development perspectives of the World Health Organization. J Med Virol 31: 62
Anon (1990) Potential use of live viral and bacterial vectors for vaccines. WHO Meeting, Geneva, 19–22 June, 1989. Vaccine 8: 425
Institute of Medicine (1986) New Vaccine Development: Establishing Priorities. Vol II. Diseases of Importance in Developing Countries. Washington D.C., National Academy Press, 432 pp
Gubler DJ (1991) Dengue hemorrhagic fever: a global update. Virus Info Exch Newsletter 8: 2
Scott RMcN, Eckels KH, Bancroft WH, Summers PL, McCown JM, Anderson JH, Russell PK (1983) Dengue 2 vaccine: dose-response in volunteers in relation to yellow fever immune status. J Infect Dis 148: 1055
Bhamarapratavi N, Yoksan S, Chayaniyayothin T, Angsubphakorn S, Bunyratvej A (1987) Immunization with a live attenuated dengue-2-virus candidate vaccine (16681-PDK 53) : clinical, immunological and biological responses in adult volunteers. Bull WHO 65: 189
Bhamarapratavi N, Yoksan S (1989) Study of bivalent dengue vaccine in volunteers. Lancet 1: 770
Brandt WE (1990) Development of dengue and Japanese encephalitis vaccines. J Infect Dis 162: 577
Rice CM, Lenches EM, Eddy SR, Shin SJ, Sheets RL, Strauss JH (1985) Nucleotide sequence of yellow fever virus: implications for flavivirus gene expression and evolution. Science 229: 726
Chambers TJ, Hahn CS, Galler R, Rice CM (1990) Flavivirus genome organization, expression and replication. Ann Rev Microbiol 44: 649
Bray M, Zhao B, Markoff L, Eckels KH, Chanock RM, Lai CJ (1989) Mice immunized with recombinant vaccinia virus expressing dengue 4 virus structural proteins with or without nonstructural protein NS1 are protected against fatal dengue encephalitis. J Virol 63: 2853
Zhang Y M, Hayes EP, McCarty TC, Dubois DR, Summers PL, Eckels KH, Chanock RM, Lai CJ (1988) Immunization of mice with dengue structural proteins and nonstructural protein NSl expressed by baculovirus recombinant induces resistance to dengue virus encephalitis. J Virol 62: 3027
Falgout B, Bray M, Schlesinger J, Lai CJ (1990) Immunization of mice with recombinant vaccinia virus expressing dengue virus nonstructural protein NS1 protects against lethal dengue encephalitis. J Virol 64: 4356
Mason PW, Pincus S, Foumier MJ, Mason TL, Shope RE, Paoletti E (1991) Japanese encephalitis virus-vaccinia recombinants produce particulate forms of the structural membrane proteins and induce high levels of protection against lethal JEV infection. Virology 180: 294
Men R, Bray M, Lai CJ (1991) Carboxy-terminally truncated dengue virus envelope glycoproteins expressed on the cell surface and secreted extracellularly exhibit increased immunogenicity in mice. J Virol 65: 1400
Deubel V, Bordier M, Megret F, Gentry MK, Schlesinger JJ, Girard M (1991) Processing, secretion, and irnmunoreactivity of carboxy terminally truncated dengue-2 virus envelope proteins expressed in insect cells by recombinant baculoviruses. Virology 180: 442
Lai CJ, Zhao Z, Hori H, Bray M (1991) Infectious RNA transcribed from stably cloned full-length cDNA of dengue type 4 virus. Proc Natl Acad Sci (USA) (in press)
Hoke CH, Nisalak A, Sangawhipa N, Jatanasen S, Laorakapongse T, Innis BL, Kotchasenee S, Gingrich JB, Latendresse J, Fukai K, Burke DS (1988) Protection against Japanese encephalitis by inactivated vaccines. N Engl J Med 319: 608
Xin YY, Ming ZG, Peng GY, Jian A, Min LH (1988) Safety of a live-attenuated Japanese encephalitis virus vaccine (SA14–14–2) for children. Am J Trop Med Hyg 39: 214
Eckels KH, Yong-Xin Y, Dubois DR, Marchette NJ, Trent DW, Johnson AJ (1988) Japanese encephalitis virus live-attenuated vaccine, Chinese strain SA14–14–2; adaptation to primary canine kidney cell cultures and preparation of a vaccine for human usc. Vaccine 6: 513
Nitayaphan S, Grant JA, Chang G -J, Trent DW (1990) Nucleotide sequence of the virulent SA-14 strain of Japanese encephalitis virus and its attenuated vaccine derivative, SA14–14–2. Virology 177: 541
Sumiyoshi H, Mori C, Fuke I, Morita K, Kuhara S, Kondou J, Kikuchi Y, Nagamatu H, Igarashi A (1987) Complete nucleotide sequence of the Japanese encephalitis virus genome RNA. Virology 161: 497
Tice TR, Cowsar DR (1984) Biodegradable controlled release parenteral systems. Pharmacol Technol J 8: 26
DeCock KM, Monath TP, Nasidi A, Tukei PM, Enriquez J, Lichfield P, Craven RB, Fabiyi A, Okafor BC, Ravaonjanahary C, Sorungbe A (1988) Epidemic yellow fever in eastern Nigeria, 1986. Lancet 1: 630
Nasidi A, Monath TP, DeCock K, Tomori O, Cordellier R, Olaleye OD, Harry TO, Adeniyi JA, Sorungbe AO, Ajose-Coker AO, van der Laan G, Oyediran ABO (1989) Urban yellow fever epidemic in western Nigeria, 1987. Trans R Soc Trop Med Hyg 83: 401
Monath, TP, Nasidi A.Should yellow fever vaccine be a part of the Expanded Programme of Immunization in Africa? A cost-effectiveness analysis for Nigeria. Bull. WHO (submitted)
Hall AJ, Greenwood BM, Whittle H (1990) Modern Vaccines. Practice in developing countries. Lancet 335: 774
Khanum S, Uddin N, Mann G, Tomkins A (1987) Comparison of Edmonston-Zagreb and Schwarz strains of mneasles vacine given by aerosol or subcutaneous injection. Lancet 1: 150
Monath TP, Kinney RM, Schlesinger JJ, Brandriss MW, Bres P (1983) Ontogeny of yellow fever 17D vaccine: RNA olgonucleotide fingerprint and monoclonal antibody analysis of vaccines produced worldwide. J Gen Virol 64: 627
Liprandi F (1981) Isolation of plaque variants differing in virulence from the 17D strain of yellow fever virus. J Gen Virol 56: 363
Gould EA, Buckley A, Cane PA, Higgs S, Cammack N (1989) Use of a monoclonal antibody specific for wild-type yellow fever virus to identify a wild-type antigenic variant in 17D vaccine pools. J Gen Virol 70: 1889
Hahn CS, Dalrymple JM, Strauss JH, Rice CM (1987) Comparison of the virulent Asibi strain of yellow fever virus with the 17D vaccine strain derived from it. Proc Natl Acad Sei (USA) 84: 2019
Rice CM, Grakoui A, Galler R, Chambers TJ (1989) Transcription of infectious virus RNA from full-length cDNA templates produced by in vitro ligation. New Biology 1: 285
Robbins A, Freeman P (1988) Obstacles to developing vaccines for the Third World. Sei Am 259: 126
Bloom BR, Cerami A (eds) (1989) Biomedical science and the third world. Under the volcano. Ann NYAcad Sci 569: 1
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1992 Springer Science+Business Media New York
About this chapter
Cite this chapter
Monath, T.P. (1992). The Challenge: Biotechnology Transfer to Public Health. Examples from Arbovirology. In: Walker, D.H. (eds) Global Infectious Diseases. Springer, Vienna. https://doi.org/10.1007/978-3-7091-3449-8_2
Download citation
DOI: https://doi.org/10.1007/978-3-7091-3449-8_2
Publisher Name: Springer, Vienna
Print ISBN: 978-3-211-82329-3
Online ISBN: 978-3-7091-3449-8
eBook Packages: Springer Book Archive