Abstract
Cysticercosis has existed since ancient times. The life cycle of the cestode responsible for this condition (Taenia solium) is often misunderstood. It is important to distinguish between taeniasis, an intestinal infection with the adult tapeworm, and cysticercosis, a tissue infection with larval T. solium. Humans are suseptible to both conditions. Clinically, cysticercosis exhibits great diversity. Neurocysticercosis is the most clinically significant form of the disease, but cysts can occur in almost any anatomic location. Geographic and age/gender-related differences in clinical manifestations also occur. Diagnosis depends on the appropriate use of radiologic, immunologic, and histopathologic techniques. Both surgical and medical treatments are available. The T. solium taeniasis/cysticercosis complex is endemic throughout the developing world where human consumption of inadequately cooked pork and swine husbandry practices favor transmission. The importance of person-to-person transmission is being increasingly recognized. Recent advances include the use of magnetic resonance imaging and improved immunologic techniques for diagnosis; alternative medical treatment with the new antiparasitic agent, albendazole; and recent epidemiologic insights into risk factors and transmission dynamics in both endemic and nonendemic areas.
Despite considerable progress, many unanswered questions remain. Future efforts should focus on controlled clinical trials, wider application of available technology, and expanded epidemiologic studies. Intervention efforts should emphasize education and social determinants of disease. Finally, better utilization of existing data to foster prevention is crucial. Despite a wide range of clinical and epidemiologic variables, the single most consistent and important aspect of this disease is that it is preventable.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Nieto D (1982) Historical notes on cysticercosis. In: Flisser A, Willms K, Laclette JP, Larralde C, Ridaura C, Beltran F (eds) Cysticercosis: present state of knowledge and perspectives.Academic Press Inc, New York, pp 1–2
Acha PD, Szyfres B (1987) Zoonoses and communicable diseases common to man and animals. 2nd ed. Washington, DC, Pan American Health Organization, pp 749–760
Richards F, Schantz PM (1991) Laboratory diagnosis of cysticercosis. Clin Lab Med 11: 1011–1028
Beaver PC, Jung RC, Cupp EW (1948) Clinical parasitology. 9th ed. Philadelphia, Lee and Febiger, pp 512–519
Nash TE (1986) Diagnosis and treatment of cysticercosis. In: Remington JS, Swartz MN (eds) Current clinical topics in infectious diseases. New York, McGraw Hill 7: 297–310
Sotelo J, Guerrero V, Rubio F (1985) Neurocysticercosis: a new classification based on active and inactive forms. A study of 753 cases. Arch Intern Med 145: 442–445
Bittencourt PRM, Costa AJ, Oliveira TV, et al (1990) Clinical, radiological and cerebrospinal fluid presentation of neurocysticercosis, a prospective study. Arq Neuropsiquiatr (Sao Paulo) 48: 286–295
Scharf D (1988) Neurocysticercosis: two hundred thirty-eight cases from a California hosp i tal. Arch Neurol 45: 777–780
Del Brutto OH, Sotelo J (1988) Neurocysticercosis: an update. Rev Infect Dis 10: 1075–1087
Flisser A, Larralde C (1986) Cysticercosis. In: Walls KW, Schantz PM (eds) Immunodiagnosis of parasitic diseases. Helminthic diseases, Academic Press Inc, Florida, pp 109–161
Dixon HBF, Lipscomb FM (1961) Cysticercosis: An analysis and follow-up of 450 cases. In: Report Series No. 299. London, Her Majesty’s Stationary Office
Earnest MP, Reller LB, Filley CM, Grek AJ (1987) Neurocysticercosis in the United States: 35 cases and a review. Rev Infect Dis 9: 961–979
Wei GZ, Li CJ, Meng JM, Ding MC (1988) Cysticercosis of the central nervous system. A clinical study of 1400 cases. Chin Med J 101: 493–500
Nash TE, Neva FA (1984) Recent advances in the diagnosis and treatment of cerebral cysticercosis. N Engl J Med 311: 1492–1496
Rabiela MT, Rivas A, Flisser A (1989) Morphological types of T solium cysticerci. Parasitol Today 5: 357–358
Welsh NH, Peters AL, Crewe-Brown W, Blignaut P, Donnoli P, Da Souza BS, Javary Y (1987) Ocular cysticercosis. A report of 13 cases. S Afr Med J 71: 719–722
Santayo H, Corona R, Sotelo J (1991) Total recovery of visual function after treatment for cerebral cysticercosis. N Engl J Med 324: 1137–1139
Pansey BK, Basra KS, Pasricha R (1989) Medically treated cysticercosis in a blind child. A case report. Surg Neurol 32: 56–58
DiLoreto DA, Kennedy RA, Neigel JM, Rootman J (1990) Infestation of extraocular muscle by cysticercus cellulosae. Br J Ophthalmol 74: 751–752
Cheung YY, Steinbaum S, Yuh W, Chiu L (1987) MR findings in extracranial cysticercosis: case report. J Assist Tomography 11: 179–181
Chi JG, Sung RH, Cho SY (1988) Tissue parasitic diseases in Korea. J Korean Med Sci 3: 51–62
Vuong PN (1989) Fine needle aspiration cytology of subcutaneous cysticercosis of the breast: case report and pathogenic discussion. Acta Cyto 33: 659–662
Wadia N, Desai S, Bhatt M (1988) Disseminated cysticercosis. New observations, including CT scan findings and experience with treatment by praziquantel. Brain 111: 597–614
California Morbidity (1990) Cysticercosis in California. June 15, 1990, 23–24.
Loo L, Braude A (1982) Cerebral cysticercosis in San Diego: a report of 23 cases and a review of the literature. Medicine (Baltimore) 61: 341–359
Sotelo J, Marin C (1987) Hydrocephalus secondary to cysticercotic arachnoiditis. A long-term follow-up of 92 cases. J Neurosurg 66: 686–689
Sotelo J, Del Brutto OH, Penagos P, Escobedo F, Torres B, Rodriguez-Carbajal J, Rubio-Donnadieu F (1990) Comparison of therapeutic regimen of anticysticercal drugs for parenchymal brain cysticercosis. J Neurol 237: 69–72
Sotelo J, Escobedo F, Rodriguez-Carbajal J, Torres B, Rubio-Donnadieu F (1984) Therapy of parenchymal brain cysticercosis with praziquantel. N Engl J Med 310: 1001–1007
Robles C, Sedano AM, Vargas-Tentori N, Galindo-Virgen S (1987) Long-term results of praziquantel therapy in neurocysticercosis. J Neurosurgery 66: 359–363
Van Dellen JR, McKeon CP (1988) Praziquantel in active cerebral cysticercosis. Neurosurgery 22: 92–96
Rangel R, Torres B, Del Brutto O, Sotelo J (1987) Cysticercotic encephalitis: a severe form in young females. Am J Trop Med Hyg 36: 387–392
Del Brutto OH, Garcia E, Talarnas O, Sotelo J (1988) Sex-related severity of inflamation in parenchymal brain cysticercosis. Arch Intern Med 148: 544–546
Lopez-Hernandez A (1983) Clinical manifestations and sequential computed tomography scans of cerebral cysticercosis in childhood. Brain Dev 6: 269–277
Mitchell WG, Snodgrass SR (1985) Intraparenchymal cerebral cysticercosis in children: a benign prognosis. Neurol 1: 151–156
Mitchell WG, Crawford TO (1988) Intraparenchymal cerebral cysticercosis in children: diagnosis and treatment. Pediatr 82: 76–82
Reeder MM, Palmer PES (1981) The radiology of tropical diseases with epidemiogical, pathological and clinical correlation. Baltimore, The Williams and Wilkins Co, pp 911— 931
Byrd SE, Daryabagi J, Thompson R, Zant J, Locke GE, Biggers S (1985) The computed tomographic spectrum of cerebral cysticercosis. J Natl Med Assoc 78: 553–560
Gottstein B, Zini D, Schantz PM (1987) Species-specific immunodiagnosis of Taenia solium cysticercosis by ELISA and immunoblotting. Trop Med Parasitol 38: 299–303
Tsang VCW, Brand JA, Boyer AE (1989) An enzyme-linked immunoelectrotransfer blot assay and glycoprotein antigens for diagnosing human cysticercosis (Taenia solium) . J Infect Dis 159: 50–59
Tsang VCW, Pilcher JA, Zhou W, et al (1991) Efficacy of the imm uno blo t assay for cysticercosis in pigs and modulated expression of distinct IgM/IgG activities to Taenia solium antigens in experimental infections. Vet Immunol Immunopathol 29: 69–78
Nuñez R, Muñoz A, Nuñez C, Gomez B (1989) A micro ELISA for the diagnosis of cerebral cysticercosis. J Immunoassay 10: 169–178
Schantz PM, Sarti-Gutierrez E (1989) Diagnostic methods and epidemiologic surveillance of Taenia solium infection. Acta Leidensia 57: 153–163
Feldman M, Plancarte A, Sandoval M, Wilson M, Flisser A (1990) Comparison of two assays (EIA and EITB) and two samples (saliva and serum) for the diagnosis of neurocysticercosis. Trans R Soc Trop Med Hyg 84:559–562
Wilson M, Bryan RT, Fried JA, et al (1991) Clinical evaluation of the cysticercosis enzyme-linked immunoelectrotransfer blot (EITB)) in patients with neurocysticercosis. J Inf Dis 164: 1007–1009
Kung ITM, Lee D, Yu HC (1989) Soft tissue cysticercosis: diagnosis by fine-needle aspiration. Am J Clin Pathol 92: 834–835
Sparks AK, Neahe RC, Connor DH (1976) Cysticercosis. In: Binford CH, Connor DH (eds) Pathology of tropical and extraordinary diseases. Washington, DC, Armed Forces Institute of Pathology, pp 539–542
Trenes JO, Trelles L (1979) Cysticercosis of the nervous system. In: Vinken PJ, Bruyn GW (eds) Handbook of clinical neurology. Amsterdam, NY, North Holland, pp 291–320
Case Records of the Massachusetts General Hospital (Case 20–1990) (1990) N Engl J Med 322: 1446–1457
Binstock PD, Azimi PH, Williams RA (1987) Cerebral cysticercosis in a 22-month-old infant. Am J Clin Pathol 88: 655–658
Zhi-biao X Wen-kai C, Hui-lan Z, et al (1985) Praziquantel in treatment of cysticercosis cellulosae: report of 200 cases. Chin Med J 98: 489–494
Castano S, Botero D (1985) Treatment of neurocysticercosis with praziquantel in Columbia. Progress in Clinical Neurosciences 2: 220–321
Joubert J, Joubert MJ, Lombaard CM (1985) Neurocysticercosis: a comprehensive approach to medical treatment. South Afr Med J 68: 11–14
King CH, Mahmoud AAF (1989) Drugs five years later: praziquantel. Ann Intern Med 110: 290–296
Spina-Franca A, Nobrega JPS, Machado LR, Livramento JA (1989) Neurocisticercose e praziquantel: evolucao a longo prazo de 100 pacientes (Portugese with English Abstract) . Arq Neuropsiquiat 47: 444–448
Pearson RD, Guerrant RL (1983) Praziquantel: a major advance in antihelminthic therapy. Ann Intern Med 99: 195–198
Moodley M, Moosa A (1989) Treatment of neurocysticercosis: is praziquantel the new hope? Lancet 1: 262
Baranski MC (1984) Treatment of dermal cysticercosis with praziquantel. A new cestocidal agent. Rev Inst Med Trop Sao Paulo 26: 259–266
Richards F (1986) Praziquantel in the treatment of cysticercosis (Letter) . JAMA 256: 349–50
Richards F (1986) Diagnosis and treatment of neurocysticercosis. IM 7: 1–11
Woo E, Yu YL Huang CY (1988) Cerebral infarct precipitated by praziquantel in neurocysticercosis: a cautionary note. Trop Geogr Med 40: 143–146
Ciferri F (1988) Delayed CSF reaction to praziquantel (Letter) Lancet
DeGhetaldi LD, Norman RM, Douville AW (1983) Cerebral cysticercosis treated biphasically with dexamethasone and praziquantel. Ann Intern Med 99: 179–181
Vasquez ML Helgi J, Sotelo J (1987) Plasma levels of praziquantel decrease when dexamethasone is given simultaneously. Neurology 37: 1561–1562
Joubert J (1990) Cysticercal meningitis: a pernicious form of neurocysticercosis which responds poorly to praziquantel. S Afr Med J 77: 528–530
Pawlowski ZS (1990) Cestodiases: taeniasis, cysticercosis, diphyllobothriasis, hymenolepiasis and others. In: Warrren KS, Mahmoud AAF (ed) Tropical and geographic medicine, 2nd ed. New York, McGraw Hill, pp 490–504
Trujillo-Valdes VM, Gonzalez-Barranco D, Orozco-Bohne R, et al (1981) Experimental treatment of cysticercosis with metrifonate. Arch Invest Med 12: 15–28
Skromme-Kadlubik G, Celis C (1981) Cysticercosis of the nervous system: treatment by means of specific internal radiation. Arch Neurol 38: 288
Tellez-Giron E, Ramos MC, Dufour L, et al (1984) Treatment of neurocysticercosis with flubendazole. Am J Trop Med Hyg 33: 627–631
Torres JR (1989) Use of praziquantel in populations at risk of neurocysticercosis (Letter) . Rev Inst Med Trop Sao Paulo 31: 290
Nemeth DJ (1989) Commentary: a study of the interactions of human, pig and the human pork tapeworm. Anthrozoos 3: 4–13
Salazar-Schettino PM (1983) Customs which predispose to Chagas’ disease and cysticercosis in Mexico. Am J Trop Med Hyg. 1983;32:1179–80.
Richards F, Schantz PM (1984) Cysticercosis and taeniasis (Letter) . N Engl J Med 312: 787
Sarti-Gutierrez EJ, Schantz PM, Lara-Aquilera R, et al (1988) Taenia solium taeniasis and cysticercosis in a Mexican village. Trop Med Parasitol 39: 194–198
Flisser A (1988) Neurocysticercosis in Mexico. Parasitol Today 4: 131–136
Gracia F, Chavarria R, Archibold C, et al (1990) Neurocysticercosis in Panama: preliminary epidemiologic study in the Azuero region. Am J Trop Med Hyg 42: 67–69
Sacks LV, Berkowitz I (1990) Cysticercosis in an urban black South African community: prevalence and risk factors. Trop Gastroenterol 11: 30–33
Schantz PM (1989) Surveillance and control programs for cestode diseases. In: Miller MJ, Love EJ (eds) Parasitic diseases: treatment and control. Florida, CRC Press, Inc, pp 275–290
Medina MT, Rosas E, Rubio-Donnadieu F, Sotelo J (1990) Neurocysticercosis as the main cause of late-onset epilepsy in Mexico. Arch Intern Med 150: 325–327
Gernmen M, Matayas Z, Pawlowski Z, et al (eds) (1983) Guidelines for Surveillance, Prevention and Control of Taeniasis/Cysticercosis. VPH/83.49. Geneva, WHO, pp 69–75
Muller R, Linywhite J, Bending JJ, Catford JC (1987) Human cysticercosis and intestinal parasitism amongst the Ekari people of Irian Jaya. J Trop Med Hyg 90: 291–296
Kent DL, Larson EB (1988) Magnetic resonance imaging of the brain and spine. Ann Intern Med 108: 402–424
Suss RA, Maravilla KR, Thompson J (1986) MR imaging of intracranial cysticercosis: comparison with CT and anatomopathologic features. AJNR 7: 235–242
Zee CS, Segall HD, Boswell W, et al (1988) MR imaging of neurocysticercosis. J Comp Assist Tomography 12: 927–934
Teitelbaum GP, Otto RJ, Lin M, et al (1989) MR imaging of neurocysticercosis. AJR 153: 857–866
Martinez HR, Rangel-Guerra R, Elizondo G, et al (1989) MR imaging in neurocysticercosis. AJNR 10: 1011–1019
Lotz J, Hewlett R, Alheit B, Bowen R (1988) Neurocysticercosis: correlative pathomorphology and MR imaging. Neuroradiol 30: 35–41
Sarti-Gutierrez E, Schantz PM, Plancarte A, et al (1991) Prevalence and risk factors for Taenia solium taeniasis and cysticercosis in humans and pigs in a village in Morelos, Mexico. Am J Trop Med Hyg (in press)
Diaz F, Garcia HH, Gilman R, et al (1991) Epidemiology of taeniasis and cysticercosis in a Peruvian tropical village. Am J Epidemiol (in press)
Garcia HH, Martinez M, Gilman R, et al (1991) Diagnosis of cysticercosis in endemic regions. Lancet 338: 549–551
Gonzalez AE, Cama V, Gilman RH, et al (1990) Prevalence and comparison of serologic assays, necropsy, and tongue examination for the diagnosis of porcine cysticercosis in Peru. Am J Trop Med Hyg 43: 194–199
Acosta E (1990) Antibodies to the metacestode of Taenia solium in the saliva from patients with neurocysticercosis. J Clin Lab Anal 4: 90–44
Correa D, Sandoval MA, Harrison LJS, et al (1989) Human neurocysticercosis: comparison of enzyme immunoassay capture techniques based on monoclonal and polyclonal antibod-ies for the detection of parasite products in cerebrospinal fluid. Trans Roy Soc Trop Med Hyg 83: 814–816
Choromanski L Estrada JJ, Kuhn RE (1990) Detection of antigens of larval Taenia solium in the cerebrospinal fluid of patients with the use of HPLC and ELISA. J Parasitol 76: 69–73
Rishi AK, McManus DP (1987) DNA probes which unambiguously distinguish Taenia solium from Taenia saginata (Letter). Lancet 1275–1276
Flisser A, Reid A, Garcia-Zepeda E, McManus DP (1988) Specific detection of Taenia saginata eggs by DNA hybridization (Letter). Lancet 1429–1430
Flisser A, Plancarte A, Correa D, et al (1990) New approaches in the diagnosis of Taenia solium cysticercosis and taeniasis. Ann Parasitol Hum Comp 65 [Suppl 1] : 95–98
Escobedo F, Penagos P, Rodriguez J, Sotelo J (1987) Albendazole therapy for neurocysticercosis. Arch Intern Med 147: 738–741
Escobedo F, Sotelo J, Penagos P, Rodriguez J, Del Brutto O (1989) Albendazole therapy for human neurocysticercosis, a controlled study with computerized tomography and magnetic resonance. Acta Leidensia 57: 247–254
Sotelo J, Penagos P, Escobedo F, Del Brutto OH (1988) Short course of albendazole therapy for neurocysticercosis. Arch Neurol 45: 1130–1133
Carpio A, Santiillan F, Leon P, Borreo A, Tinoco F(1988) New treatment of brain cysticercosis with albendazole (Abstract) . Ann Neurol 24: 144
Agapejev S, Meira DA, Barraviera B, et al (1988) Neurocysticercosis: treatment with albendazole and dextrochlorpheniramine (preliminary report) . Rev Inst Med Trop Sao Paulo 30: 387–389
Gupta R, Yupta NV (1990) Failure of praziquantel and albendazole in neurocysticercosis. JAPI 38: 313–314
Del Brutto OH, Sotelo J (1990) Albendazole therapy for subarachnoid and ventricular cysticercosis. J Neurosurg 72: 816–817
Jung H, Hurtado M, Medina MT, Sanchez M, Sotelo J (1990) Dexamethasone increases plasma levels of albendazole. J Neurol 237: 279–280
Quintero-Rodriquez E (1989) Praziquantel vs. albendazole for cysticercosis (Letter) . Neurosurgery 23: 128
Johnson KS, Harrison GB, Lightowlers MW, et al (1989) Vaccination against ovine cysticercosis using a defined recombinant antigen (Letter) . Nature 338: 585–587
Mitchell GH (1989) A vaccine for ovine cysticercosis (Editorial) . Vaccine 7: 379
Richards FO, Schantz PM, Ruiz-Tiben E, Sorvillo FJ (1985) Cysticercosis in Los Angeles County. JAMA 254: 3444–3448
Sorvillo FJ, Waterman SH, Richards FO, Schantz PM (1992) Cysticercosis surveillance: locally acquired and travel-related infections and detection of intestinal tapeworm carriers in Los Angeles county. Am J Trop Med Hyg (in press)
Centers for Disease Control (1992) Locally acquired neurocysticercosis — North Carolina, Massachusetts, and South Carolina, 1989–1991. MMWR 41: 1–4
Mata L (1982) Sociocultural factors in the control and prevention of parasitic diseases. Rev Infect Dis 4: 871–879
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1992 Springer Science+Business Media New York
About this chapter
Cite this chapter
Bryan, R.T. (1992). Current Issues in Cysticercosis: Proteins, Proglottids, Pigs, and Privies. In: Walker, D.H. (eds) Global Infectious Diseases. Springer, Vienna. https://doi.org/10.1007/978-3-7091-3449-8_11
Download citation
DOI: https://doi.org/10.1007/978-3-7091-3449-8_11
Publisher Name: Springer, Vienna
Print ISBN: 978-3-211-82329-3
Online ISBN: 978-3-7091-3449-8
eBook Packages: Springer Book Archive