Advertisement

Morphology of white matter, subcortical, dementia in Alzheimer’s disease

  • A. Brun
  • L. Gustafson
  • E. Englund
Part of the Key Topics in Brain Research book series (KEYTOPICS)

Summary

Dementing disorders are not only caused by grey matter alterations but also by white matter lesions, either together with grey matter changes or as the sole change. In dementia of Alzheimer’s type white matter disease in the nature of a selective incomplete white matter infarction was found in around 60% of cases. It was regarded as being most likely due to regional hypoperfusion of the white matter and might therefore be prevented, halted or even partly reversed by therapy.

Keywords

White Matter White Matter Lesion White Matter Change Senile Dementia Normal Pressure Hydrocephalus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Brun A, Englund E (1986) A white matter disorder in dementia of the Alzheimer type: a pathoanatomical study. Ann Neurol 19: 253–262PubMedCrossRefGoogle Scholar
  2. Brun A (1987) Frontal lobe degeneration of non Alzheimer type. I. Neuropathology. Arch Gerontol Geriatr 6: 193–208CrossRefGoogle Scholar
  3. Englund E, Brun A, Persson B (1987) Correlations between histopathologic white matter changes and proton MR relaxation times in dementia. Alzheimer Disease and Associated Disorders 1 (3): 156–170PubMedCrossRefGoogle Scholar
  4. Englund E, Brun A, Alling C (1988) White matter changes in dementia of Alzheimer’s type. Brain 3: 1425–1539CrossRefGoogle Scholar
  5. Filley CM, Franklin GM, Heaton RK, Rosenberg NL (1989) White matter dementia. Clinical disorders and implications. Neuropsych Neuropsychol Behav Neurol 1 (4): 239–254Google Scholar
  6. George AE, deLeon MJ, Ferris SH, Kricheff II (1981) Parenchymal CT correlates of senile dementia (Alzheimer’s disease): loss of grey-white matter discriminability. AJNR 2: 205–211PubMedGoogle Scholar
  7. Gottfries CG, Karlsson I, Svennerholm L (1985) Senile dementia — a white matter disease? In: Gottfries CG (ed) Normal ageing, Alzheimer’s disease and senile dementia. Editions de’l Université, Bruxelles, pp 111–118Google Scholar

Copyright information

© Springer-Verlag Wien 1990

Authors and Affiliations

  • A. Brun
    • 1
  • L. Gustafson
    • 2
  • E. Englund
    • 1
  1. 1.Institute of Pathology, Department of NeuropathologyUniversity HospitalLundSweden
  2. 2.Department of PsychogeriatricsUniversity HospitalLundSweden

Personalised recommendations