Cognitive enhancing properties of antagonist β-carbolines: new insights into clinical research on the treatment of dementias?
In animal studies, ZK 93426 antagonised scopolamine-induced decrements in certain tests measuring memory or vigilance, but did not show any effect when given on its own. On the other hand, studies in humans indicated that ZK 93426 selectively improves delayed recall of pictures shown after its administration. Additionally, evidence has been adduced for an improvement of performance in attentional tasks induced by ZK 93426.
In a memory test sensitive to scopolamine effects (word list), ZK 93426 had neither an effect on its own nor did it antagonise scopolamine induced decrements. Further studies in combination with scopolamine are required to clarify this apparent contradiction between the animal and the human data.
KeywordsBasal Forebrain Inverse Agonist Spontaneous Alternation Vigilance Task Muscarinic Antagonist Scopolamine
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