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In vivo studies of hippocampal atrophy in Alzheimer’s disease

  • M. J. de Leon
  • A. E. George
  • L. A. Stylopoulous
  • D. C. Miller
  • G. Smith
Part of the Key Topics in Brain Research book series (KEYTOPICS)

Summary

Using 5 mm negative angulation CT scans, observations on the temporal lobes and hippocampal areas were made on 113 Alzheimer (AD) patients and 72 controls. The results indicate that hippocampal changes including dilatation of the choroidal and hippocampal fissures, appear to be an early feature of AD. Over a three year interval these changes are predictive of AD type clinical deterioration in non-demented elderly subjects. The CT hippocampal changes are correlated with postmortem hippocampal changes. Hippocampal evaluations in individuals <80 years of age are a useful addition to the diagnostic workup of AD patients.

Keywords

Hippocampal Formation Hippocampal Atrophy Perforant Pathway Choline Acetyl Granulovacuolar Degeneration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Ball MJ (1978) Topographic distribution of neurofibrillary tangles and granulovacuolar degeneration in hippocampal cortex of aging and demented patients. A quantitative study. Neuropathologica 42: 73–80CrossRefGoogle Scholar
  2. Ball MJ, Hachinski V, Fox A, Kirshen AJ, Fisman M, Blume W, Kral VA, Fox H (1985) A new definition of Alzheimer’s disease: a hippocampal dementia. Lancet i: 14–16Google Scholar
  3. Davies P, Maloney AJF (1976) Selective loss of central cholinergic neurons in Alzheimer’s disease. Lancet ii: 1403Google Scholar
  4. Leon MJ, McRae T, Tsai JR, George AE, Marcus DL, Freedman M, Wolf AP, McEwen B (1988) Abnormal hypercortisolemic response in Alzheimer’s disease linked to hippocampal atrophy. Lancet ii: 391–392Google Scholar
  5. Leon MJ, George AE, Stylopoulos LA, Smith G, Miller DC (1989) Early marker for Alzheimer’s disease: the atrophic hippocampus. Lancet ii: 672–673Google Scholar
  6. George AE, de Leon MJ, Stylopoulos LA, Miller J, Kluger A, Smith G, Miller DC (1990) Temporal lobe CT diagnostic features of Alzheimer’s disease: dilatation of the choroidal/hippocampal fissure complex. Am J Neuroradiol 11: 101–107PubMedGoogle Scholar
  7. Hyman BT, Van Hoesen GW (1988) Sites of earliest Alzheimer-type pathological changes in entorhinal cortex and hippocampus visualized by ALZ-50 immunocytochemistry. Soc Neurosci Abstr 14 (2): 1084 (Abstract)Google Scholar
  8. Hyman BT, Van Hoesen GW, Damasio AR (1987) Alzheimer’s disease: glutamate depletion in the hippocampal perforant pathway zone. Ann Neurol 22:37 —40Google Scholar
  9. Hyman BT, Van Hoesen GW, Damasio AR, Barnes CL (1984) Alzheimer’s disease: cell-specific pathology isolates the hippocampal formation. Science 225:1168 —1170Google Scholar
  10. Kemper T (1984) Neuroanatomical and neuropathological changes in normal aging and in dementia. In: Albert ML (ed) Clinical neurology of aging. Oxford University Press, New York, pp 9–52Google Scholar
  11. LeMay M, Stafford JL, Sandor T, Albert M, Haykal B, Zamani A (1986) Statistical assessment of perceptual CT scan ratings in patients with Alzheimer type dementia. J Comput Assist Tomogr 10: 802–809PubMedCrossRefGoogle Scholar
  12. Mann DMA, Esiri MM (1988) The site of the earliest lesions of Alzheimer’s disease. N Engl J Med 318 (12): 789–790PubMedCrossRefGoogle Scholar
  13. Powers RE, Struble RG, Casanova MF, O’Connor DT, Kitt CA, Price DL (1988) Innervation of human hippocampus by noradrenergic systems: normal anatomy and structural abnormalities in aging and Alzheimer’s disease. Neuroscience 25: 401–417PubMedCrossRefGoogle Scholar
  14. Reisberg B, Ferris SH, de Leon MJ, Crook T (1982) The global deterioration scale for assessment of primary degenerative dementia. Am J Psychiatry 139: 1136–1139PubMedGoogle Scholar
  15. Seab JP, Jagust WS, Wong SFS, Roos MS, Reed BR, Budinger TF (1988) Quantitative NMR measurements of hippocampal atrophy in Alzheimer’s disease. Magn Reson Med 8: 200–228PubMedCrossRefGoogle Scholar
  16. Selkoe D, Kosik K (1983) Neurochemical changes with aging. In: Albert M (ed) The clinical neurology of aging. Oxford University Press, New York, pp 53–75Google Scholar
  17. Terry RD, Peck A, De Teresa R, Schechter K, Horoupian DS (1981) Some morphometric aspects of the brain in senile dementia of the Alzheimer type. Ann Neurol 10: 184–192PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Wien 1990

Authors and Affiliations

  • M. J. de Leon
    • 1
  • A. E. George
    • 1
  • L. A. Stylopoulous
    • 1
  • D. C. Miller
    • 1
  • G. Smith
    • 1
  1. 1.Departments of Psychiatry, Radiology and PathologyNew York University School of MedicineNew YorkUSA

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