Summary
We propose a classification of familial Alzheimer’s disease (FAD) based on our clinical and pathological analysis of 32 kindreds with multigeneration dementia. The classification can briefly be stated as follows I. Early onset FAD with mean age of onset before 50 years; II. Late onset FAD with mean age of onset after 60 years; III. Intermediate/variable onset FAD; IV. Familial dementia with atypical Alzheimer changes; V. FAD without multigeneration involvement.
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References
Bird TD, Lampe TH, Nemens EJ, Miner GW, Sumi SM, Schellenberg GD (1988) Familial Alzheimer’s disease in American descendants of the Volga Germans: probable genetic founder effect. Ann Neurol 23: 25–31
Bird TD, Sumi SM, Nemens EJ, Nochlin D, Schellenberg G, Lampe TH, Sadovnick A, Chui H, Miner GW, Tinklenberg J (1989) Phenotypic heterogeneity in familial Alzheimer’s disease: a study of 24 kindreds. Ann Neurol 25: 12–25
Cupples LA, Terrin NC, Meyers RH, D’Agostino RB (1989) Using survival methods to estimate age-at-onset distributions for genetic diseases with an application to Huntington disease. Genet Epidemiol 6: 361–371
McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM (1984) Clinical diagnosis of Alzheimer’s disease. Neurology 34: 939–944
Morris JC, Cole M, Banker BQ, Wright D (1984) Hereditary dysphasic dementia and the Pick-Alzheimer spectrum. Ann Neurol 16: 455–466
Sobel E, Davanipour Z, Alter M (1988) Genetic analysis of late-onset diseases using first-degree relatives. Neuroepidemiology 7: 81–88
Sumi SM, Nochlin D, Bird TD (1988) Familial presenile dementia with neurofibrillary tangles but without senile (neuritic) plaques: is this familial Alzheimer’s disease? Neurology 38 [Suppl 1]: 266
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© 1990 Springer-Verlag Wien
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Bird, T.D. et al. (1990). A proposed classification of familial Alzheimer’s disease based on analysis of 32 multigeneration pedigrees. In: Maurer, K., Riederer, P., Beckmann, H. (eds) Alzheimer’s Disease. Epidemiology, Neuropathology, Neurochemistry, and Clinics. Key Topics in Brain Research. Springer, Vienna. https://doi.org/10.1007/978-3-7091-3396-5_5
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DOI: https://doi.org/10.1007/978-3-7091-3396-5_5
Publisher Name: Springer, Vienna
Print ISBN: 978-3-211-82197-8
Online ISBN: 978-3-7091-3396-5
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