High resolution regional cerebral blood flow measurements in Alzheimer’s disease and other dementia disorders

  • J. Risberg
  • L. Gustafson
  • A. Brun
Part of the Key Topics in Brain Research book series (KEYTOPICS)


High-resolution regional cerebral blood flow (rCBF) measurements using inhalation of 133xenon and a newly developed 254 detector system were performed in patients with organic dementia. Neuropathological findings were compared to rCBF in 13 deceased patients. A close relationship was found between the localization and severety of atrophy and/or infarcts situated in the cortical mantle and the rCBF-findings. Pathological changes in subcortical regions and white matter showed a less clear relationship to rCBF. The rCBF technique was found to be a useful diagnostic tool.


Regional Cerebral Blood Flow Frontal Flow Inhalation Technique Neuropathological Finding Cortical Mantle 
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Copyright information

© Springer-Verlag Wien 1990

Authors and Affiliations

  • J. Risberg
    • 1
  • L. Gustafson
    • 2
  • A. Brun
    • 3
  1. 1.Departments of PsychiatryUniversity HospitalLundSweden
  2. 2.PsychogeriatricsUniversity HospitalLundSweden
  3. 3.Institute of Pathology, Department of NeuropathologyUniversity HospitalLundSweden

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