High resolution regional cerebral blood flow measurements in Alzheimer’s disease and other dementia disorders
High-resolution regional cerebral blood flow (rCBF) measurements using inhalation of 133xenon and a newly developed 254 detector system were performed in patients with organic dementia. Neuropathological findings were compared to rCBF in 13 deceased patients. A close relationship was found between the localization and severety of atrophy and/or infarcts situated in the cortical mantle and the rCBF-findings. Pathological changes in subcortical regions and white matter showed a less clear relationship to rCBF. The rCBF technique was found to be a useful diagnostic tool.
KeywordsRegional Cerebral Blood Flow Frontal Flow Inhalation Technique Neuropathological Finding Cortical Mantle
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