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Comparison between cerebral glucose metabolism and late evoked potentials in patients with Alzheimer’s disease

  • B. Szelies
  • T. Wullen
  • R. Adams
  • M. Grond
  • H. Karbe
  • K. Herholz
  • W.-D. Heiss
Part of the Key Topics in Brain Research book series (KEYTOPICS)

Summary

In an ongoing 2-year-prospective study 21 patients with probable Alzheimer’s disease (Global Deterioration Scale 3–6) using NINCDS-ADRDA criteria were examined by PET of glucose metabolism and P300 brain mapping to compare the power of both functional imaging methods to distinguish between patients and normals.

Data of P300 latency and topography were compared with a ratio of glucose metabolism in frontal and temporoparietal association areas over typically not affected regions. PET proved to be a method with high sensitivity (85%) and specificity (90%) while P300 mapping was less sensitive with 58% at a specificity of 90%.

Keywords

P300 Latency Metabolic Ratio Cerebral Glucose Metabolism Prediction Limit Subjective Memory Complaint 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Wien 1990

Authors and Affiliations

  • B. Szelies
    • 1
  • T. Wullen
    • 1
  • R. Adams
    • 1
  • M. Grond
    • 1
  • H. Karbe
    • 1
  • K. Herholz
    • 1
  • W.-D. Heiss
    • 1
  1. 1.Klinik für Neurologie der UniversitätMax-Planck-Institut für Neurologische ForschungCologneFederal Republic of Germany

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