Comparison between cerebral glucose metabolism and late evoked potentials in patients with Alzheimer’s disease
In an ongoing 2-year-prospective study 21 patients with probable Alzheimer’s disease (Global Deterioration Scale 3–6) using NINCDS-ADRDA criteria were examined by PET of glucose metabolism and P300 brain mapping to compare the power of both functional imaging methods to distinguish between patients and normals.
Data of P300 latency and topography were compared with a ratio of glucose metabolism in frontal and temporoparietal association areas over typically not affected regions. PET proved to be a method with high sensitivity (85%) and specificity (90%) while P300 mapping was less sensitive with 58% at a specificity of 90%.
KeywordsP300 Latency Metabolic Ratio Cerebral Glucose Metabolism Prediction Limit Subjective Memory Complaint
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