EEG- and cognitive changes in Alzheimer’s disease — a correlative follow-up study

  • M. B. Streifler
  • M. Simanyi
  • P. Fischer
  • W. Danielczyk
Part of the Key Topics in Brain Research book series (KEYTOPICS)


Electroencephalograms (EEG) obtained in a two years follow up period from 39 patients with Alzheimer’s disease — presenile (AD) and senile (SDAT) — were compared with psychomental ratings (MMS and OMDS) and with EEG records from two age-matched normal control groups, comprising 33 subjects. Normal EEGs were obtained 7 times more often in controls than in Alzheimer patients and alpha was mildly to severely disturbed in close to 68 percent of the latter.

The EEG-differences between controls and patients were significant for global rating, alpha activity and diffuse slowing. Beta activity was significantly reduced in SDAT. Alpha and beta activity were significantly more impaired in SDAT than in AD, but their changes with progression of disease did not differ significantly. Close to 10% of initial records were and remained normal.

The study of the sequential EEGs showed a good correlation between global rating, slowing of basic rhythm and irregularity of alpha activity and degrees of dementia.

This study, in consistency with most of reports in the literature shows, that sequential recording of EEG is a valuable tool in the confirmation of Alzheimer’s disease in doubtful cases and in the differentiation of this disease from normal ageing.


Alzheimer Patient Global Rating Alpha Activity Senile Dementia Beta Activity 


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Copyright information

© Springer-Verlag Wien 1990

Authors and Affiliations

  • M. B. Streifler
    • 1
  • M. Simanyi
    • 2
  • P. Fischer
    • 3
  • W. Danielczyk
    • 2
    • 4
  1. 1.Sackler Faculty of MedicineTel Aviv UniversityIsrael
  2. 2.Neurology DepartmentGeriatric Hospital-LainzViennaAustria
  3. 3.Neurological InstituteUniversity of ViennaAustria
  4. 4.Ludwig Boltzmann Institute for Aging ResearchWorkgroup Alzheimer-Dementia ResearchViennaAustria

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