Regulation of EEG delta activity by the cholinergic nucleus basalis
To study the relationship between cholinergic pathology and EEG deterioriation, spectral EEG and CSF neurotransmitter markers were examined in 23 probable AD patients. CSF acetylcholinesterase was correlated with delta power and alpha/delta ratio. In an autopsy study, cortical ChAT activity and the nucleus basalis cell number were lower and delta power higher in 4 demented patients than in 6 age-matched controls. In the group of demented patients, the lowest ChAT activities were associated with the highest delta power.
KeywordsHigh Pressure Liquid Chromatography Nucleus Basalis Demented Patient ChAT Activity Delta Power
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