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Alzheimer’s Disease. Epidemiology, Neuropathology, Neurochemistry, and Clinics pp 437–445Cite as

Regulation of EEG delta activity by the cholinergic nucleus basalis

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Part of the book series: Key Topics in Brain Research ((KEYTOPICS))

Summary

To study the relationship between cholinergic pathology and EEG deterioriation, spectral EEG and CSF neurotransmitter markers were examined in 23 probable AD patients. CSF acetylcholinesterase was correlated with delta power and alpha/delta ratio. In an autopsy study, cortical ChAT activity and the nucleus basalis cell number were lower and delta power higher in 4 demented patients than in 6 age-matched controls. In the group of demented patients, the lowest ChAT activities were associated with the highest delta power.

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Author information

Authors and Affiliations

  1. Department of Neurology, University of Kuopio, P.O.B. 6, SF-70211, Kuopio, Finland

    Prof. P. J. Riekkinen

  2. Department of Neurology, University of Kuopio, Kuopio, Finland

    P. J. Riekkinen Jr., H. Soininen, K. J. Reinikainen, V. Laulumaa & T. Halonen

  3. Department of Neurophysiology, University of Kuopio, Kuopio, Finland

    V. S. J. Partanen

  4. Department of Pathology, University of Kuopio, Kuopio, Finland

    L. Paljärvi

Authors
  1. Prof. P. J. Riekkinen
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  2. P. J. Riekkinen Jr.
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  3. H. Soininen
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  4. K. J. Reinikainen
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  5. V. Laulumaa
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  6. V. S. J. Partanen
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  7. T. Halonen
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  8. L. Paljärvi
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Editor information

Editors and Affiliations

  1. Department of Psychiatry, University of Würzburg, Würzburg, Federal Republic of Germany

    Konrad Maurer , Peter Riederer  & Helmut Beckmann ,  & 

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© 1990 Springer-Verlag Wien

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Riekkinen, P.J. et al. (1990). Regulation of EEG delta activity by the cholinergic nucleus basalis. In: Maurer, K., Riederer, P., Beckmann, H. (eds) Alzheimer’s Disease. Epidemiology, Neuropathology, Neurochemistry, and Clinics. Key Topics in Brain Research. Springer, Vienna. https://doi.org/10.1007/978-3-7091-3396-5_51

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  • DOI: https://doi.org/10.1007/978-3-7091-3396-5_51

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-82197-8

  • Online ISBN: 978-3-7091-3396-5

  • eBook Packages: Springer Book Archive

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