A proposed classification of familial Alzheimer’s disease based on analysis of 32 multigeneration pedigrees
We propose a classification of familial Alzheimer’s disease (FAD) based on our clinical and pathological analysis of 32 kindreds with multigeneration dementia. The classification can briefly be stated as follows I. Early onset FAD with mean age of onset before 50 years; II. Late onset FAD with mean age of onset after 60 years; III. Intermediate/variable onset FAD; IV. Familial dementia with atypical Alzheimer changes; V. FAD without multigeneration involvement.
KeywordsAmyloid Plaque Spinocerebellar Degeneration Demented Person Multigeneration Pedigree Anterior Horn Cell Disease
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