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A proposed classification of familial Alzheimer’s disease based on analysis of 32 multigeneration pedigrees

  • T. D. Bird
  • J. P. Hughes
  • S. M. Sumi
  • D. Nochlin
  • G. D. Schellenberg
  • T. H. Lampe
  • E. J. Nemens
Part of the Key Topics in Brain Research book series (KEYTOPICS)

Summary

We propose a classification of familial Alzheimer’s disease (FAD) based on our clinical and pathological analysis of 32 kindreds with multigeneration dementia. The classification can briefly be stated as follows I. Early onset FAD with mean age of onset before 50 years; II. Late onset FAD with mean age of onset after 60 years; III. Intermediate/variable onset FAD; IV. Familial dementia with atypical Alzheimer changes; V. FAD without multigeneration involvement.

Keywords

Amyloid Plaque Spinocerebellar Degeneration Demented Person Multigeneration Pedigree Anterior Horn Cell Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Bird TD, Lampe TH, Nemens EJ, Miner GW, Sumi SM, Schellenberg GD (1988) Familial Alzheimer’s disease in American descendants of the Volga Germans: probable genetic founder effect. Ann Neurol 23: 25–31PubMedCrossRefGoogle Scholar
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Copyright information

© Springer-Verlag Wien 1990

Authors and Affiliations

  • T. D. Bird
    • 1
  • J. P. Hughes
    • 1
  • S. M. Sumi
    • 1
  • D. Nochlin
    • 1
  • G. D. Schellenberg
    • 1
  • T. H. Lampe
    • 1
  • E. J. Nemens
    • 1
  1. 1.University of Washington Medical School and VA Medical CenterSeattleUSA

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