Cognitive deterioration and dementia outcome in depression: the search for prognostic factors

  • F. M. Reischies
  • P. v. Spieß
  • J.-P. Hedde
Part of the Key Topics in Brain Research book series (KEYTOPICS)


The time course of recovery of depressed patients’ cognitive deficits and the eventual outcome in dementia was studied in patients (N = 59) over 45 years of age. In only two patients could a dementing illness be verified in the follow-up. For the other patients, after a slight recovery of cognitive performances parallel to the improvement of the depressed mood, a further decline to the level of the depressed state was observed after a period of 3 years. Age (pos.), severeness of depression (neg.) and the temporal/occipito-temporal perfusion (neg.) measured by 133 Xenon SPECT were found as probable prognostic factors, related to the decline of cognitive performance.


Cognitive Performance Depressed Mood Depressed State Depressive Syndrome Remit State 
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Copyright information

© Springer-Verlag Wien 1990

Authors and Affiliations

  • F. M. Reischies
    • 2
  • P. v. Spieß
    • 1
  • J.-P. Hedde
    • 1
  1. 1.Department of PsychiatryFreie Universität BerlinBerlinGermany
  2. 2.Department of PsychiatryFreie Universität BerlinBerlin 19Germany

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