Summary
Symptoms of depression are associated with both Multi-Infarct dementia (MID) and Dementia of Alzheimer’s type (DAT). We investigated anxiety and depressed mood in 37 MID-patients and 55 DAT-patients of various stages of dementia. Diagnosis was carried out using the commonly accepted criteria of the DSM-III-R and the NINCDS-ADRDA criteria for “probable DAT”, respectively. Severity of dementia was rated by the help of the Mini-Mental State examination.
We found comparable rates of depression in mild-to-moderate MID and DAT, respectively. Severely demented DAT-patients were far less anxious and depressed than equally demented MID-patients. Progression of dementia reduced depression in DAT but favoured depressive symptoms in MID.
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References
American Psychiatric Association (1987) Diagnostic and statistical manual of mental disorders, 3rd edn (revised). APA, Washington, DC
Brink TL, Yesavage JA, Lum O, Heersema PH, Adey M, Rose TL (1982) Screening tests for geriatric depression. Clin Gerontologist 1: 37–43
Crook T, Bartus RT, Ferris SH, Whitehouse P, Cohen GD, Gershon S (1986) Age-associated memory impairment: proposed diagnostic criteria and measures of clinical change — Report of a National Institute of Mental Health Work Group. Dev Neuropsychol 2: 261–276
Cummings JL, Miller B, Hill MA, Neshkes R (1987) Neuropsychiatric aspects of multi-infarct dementia and dementia of the Alzheimer type. Arch Neurol 44: 389–393
Danielczyk W (1984) Psychiatrische Komplikationen beim Morbus Parkinson: Krankheitssymptome, Folge der Alterung oder der Therapie? Neuropsychiatr Clin 3: 145–155
Fischer P, Gatterer G, Marterer A, Danielczyk W (1988) Nonspecificity of semantic impairment in dementia of Alzheimer’s type. Arch Neurol 45: 1341–1343
Fischer P, Jellinger K, Gatterer G, Marterer A, Danielczyk W (1989) Neuropathological validation of the Hachinski Scale. J Neural Transm (P-D Sect) 1: 57
Folstein MF, Folstein SE, McHugh PR (1975) “Mini-Mental State”. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12: 189–198
Folstein MF (1983) The mini-mental state examination. In: Crook TH, Ferris S, Bartus R (eds) Assessment in geriatric psychopharmacology. Mark Powley, Connecticut, pp 47–51
Gaitz CM, Varner RV, Overall JE (1977) Pharmacotherapy for organic brain syndrome in late life. Arch Gen Psychiatry 34: 839–845
Gurland B, Toner J (1987) The epidemiology of the concurrence of depression and dementia. In: Altmann HJ (ed) Alzheimer’s disease. Plenum Press, New York, pp 45–58
Hachinski VC, Iliff LD, Zilhka E, DuBoulay GH, McAllister VL, Marshall J, Russell RWR, Symon L (1975) Cerebral blood flow in dementia. Arch Neurol 32: 632–637
Hamilton M (1960) A rating scale for depression. J Neurol Neurosurg Psychiatry 23: 56–62
Jellinger K (1990) Histopathological validation of dementia disorders in the aged. In: Battistine L (ed) Aging brain and dementia: new trends in diagnosis and therapy. Liss, New York, pp 79–97
Knesevich JW, Martin RL, Berg L, Danzinger W (1983) Preliminary report of affective symptoms in the early stages of senile dementia of the Alzheimer type. Am J Psychiatry 140: 233–235
Lawton MP, Brody EM (1969) Assessment of older people: selfmaintaining and instrumental activities of daily living. Gerontologist 9: 179–186
Lazarus LW, Newton N, Cohler B, Lesser J, Schweon C (1987) Frequency and presentation of depressive symptoms in patients with primary degenerative dementia. Am J Psychiatry 144: 41–45
McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM (1984) Clinical diagnosis of Alzheimer’s disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s disease. Neurology 34: 939–944
Reding M, Haycox J, Blass J (1985) Depression in patients referred to a dementia clinic. A three-year prospective study. Arch Neurol 42: 894–896
Reifler BV, Larson E, Hanley R (1982) Coexistence of cognitive impairment and depression in geriatric outpatients. Am J Psychiatry 139: 623–626
Reisberg B, Borenstein J, Salob SP, Ferris SH, Franssen E, Georgotas A (1987) Behavioral symptoms in Alzheimer’s disease: phenomenology and treatment. J Clin Psychiatry 48: 9–15
Rosen WG, Terry RD, Fuld PA, et al (1980) Pathological verification of ischemic score in differentiation of dementias. Ann Neurol 7: 486–488
Shader RI, Harmatz JS, Salzman C (1974) A new scale for clinical assessment on geriatric populations: Sandoz clinical assessment geriatric (SCAG). J Am Geriatr Soc 22 (3): 107–113
Sheikh JI, Yesavage JA (1986) Geriatric depression scale (GDS). Recent evidence and development of a shorter version. Clin Gerontologist 5: 165–173
Siegel B, Gershon S (1987) Dementia, depression, and pseudodementia. In: Altman HJ (ed) Alzheimer’s disease problems, prospects, and perspectives. Plenum Press, New York, pp 29–44
Sunderland T, Alterman IS, Yount D, Hill JL, Tariot PN, Newhouse PA, Mueller EA, Mellow AM, Cohen RM (1988) A new scale for the assessment of depressed mood in demented patients. Am J Psychiatry 145: 955–959
Tomlinson BE, Blessed G, Roth M (1970) Observations on the brains of demented old people. J Neurol Sci 11: 205–242
Weiss IK, Nagel CL, Aronson MK (1986) Applicability of depression scales to the old person. J Am Geriatr Soc 34: 215–218
Wragg RE, Jeste DV (1989) Overview of depression and psychosis in Alzheimer’s disease. Am J Psychiatry 146: 577–587
Yesavage JA, Brink TL (1983) Development and validation of geriatric depression screening scale: a preliminary report. J Psychiatr Res 17: 37–49
Zubenko GS, Moossy J (1988) Major depression in primary dementia. Clinical and neuropathologie correlates. Arch Neurol 45: 1182–1186
Zung WWK (1965) A self-rating depression scale. Arch Gen Psychiatry 12: 6370
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Danielczyk, W., Fischer, P., Simanyi, M., Gatterer, G., Marterer, A. (1990). Symptoms of depression in the course of multi-infarct dementia and dementia of Alzheimer’s type. In: Maurer, K., Riederer, P., Beckmann, H. (eds) Alzheimer’s Disease. Epidemiology, Neuropathology, Neurochemistry, and Clinics. Key Topics in Brain Research. Springer, Vienna. https://doi.org/10.1007/978-3-7091-3396-5_43
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DOI: https://doi.org/10.1007/978-3-7091-3396-5_43
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