Urinary excretion of salsolinol enantiomers and 1,2-dehydrosalsolinol in patients with degenerative dementia
The daily urinary excretion of total (R)- and (S)-salsolinol and 1,2-dehydrosalsolinol (free + sulfoconjugate) was measured in patients with degenerative dementia. (R)-Salsolinol was detectable in the urine of 5 out of 12 patients and 1,2-dehydrosalsolinol in the urine of 10 patients, whereas (S)-salsolinol was not detectable. The urinary excretion of 1,2-dehydrosalsolinol appears to be similar in demented and parkinsonian patients, suggesting that the biosynthesis of salsolinol precursors may be similar in the two groups.
KeywordsUrinary Excretion Parkinsonian Patient Demented Patient Phenylboronic Acid Daily Excretion
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