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Nerve growth factor in serum of patients with dementia (Alzheimer type)

  • U. Stephani
  • K. Maurer
Part of the Key Topics in Brain Research book series (KEYTOPICS)

Summary

Lack of nerve growth factor (NGF) has been suggested to play a causal role in Alzheimer’s disease. Employing sensitive biological and immunological assays for NGF we determined the levels of NGF in sera of controls and patients with Alzheimer’s disease. Absence of NGF immunoreactivity and elevated levels of NGF-like bioactivity were found in sera of the patient group. This might be relevant since NGF regulates and increases the transcription rate of many genes, including those for the β-amyloid precursor and the prion protein.

Keywords

Amyotrophic Lateral Sclerosis Nerve Growth Factor Prion Protein Basal Forebrain Cholinergic Neuron Spatial Memory Impairment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Wien 1990

Authors and Affiliations

  • U. Stephani
    • 1
  • K. Maurer
    • 2
  1. 1.KinderklinikUniversity of GöttingenFederal Republic of Germany
  2. 2.Psychiatrische KlinikUniversity of WürzburgFederal Republic of Germany

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