Nerve growth factor in serum of patients with dementia (Alzheimer type)
Lack of nerve growth factor (NGF) has been suggested to play a causal role in Alzheimer’s disease. Employing sensitive biological and immunological assays for NGF we determined the levels of NGF in sera of controls and patients with Alzheimer’s disease. Absence of NGF immunoreactivity and elevated levels of NGF-like bioactivity were found in sera of the patient group. This might be relevant since NGF regulates and increases the transcription rate of many genes, including those for the β-amyloid precursor and the prion protein.
KeywordsAmyotrophic Lateral Sclerosis Nerve Growth Factor Prion Protein Basal Forebrain Cholinergic Neuron Spatial Memory Impairment
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