Summary
The concentration of somatostatin-like immunoreactivity (SLI), the molecular forms of SLI, serotonin and dopamine metabolites in cerebrospinal fluid of patients with senile dementia of Alzheimer type (SDAT), Parkinson’s disease (PD) and age-matched control patients were determined by reverse phase HPLC and by specific radioimmunoassay. The mean SLI level in the control group was 29.5 ± 8.9 fmol/ml. In SDAT and PD the mean SLI level was significantly lower (18.6 7.9 fmol/ml, 21.4 ± 8.1 fmoI/ml). HPLC separation of SLI yielded four peaks with a preponderance of Somatostatin-14 (SST-14) and Somatostatin-28 (SST-28). In SDAT and PD changes in the molecular pattern of somatostatin indicate an altered biosynthesis and/or processing of somatostatin.
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Strittmatter, M., Cramer, H., Reuner, C., Strubel, D., Kuntzmann, F. (1990). Somatostatin-like immunoreactivity and neurotransmitter metabolites in the cerebrospinal fluid of patients with senile dementia of Alzheimer type and Parkinson’s disease. In: Maurer, K., Riederer, P., Beckmann, H. (eds) Alzheimer’s Disease. Epidemiology, Neuropathology, Neurochemistry, and Clinics. Key Topics in Brain Research. Springer, Vienna. https://doi.org/10.1007/978-3-7091-3396-5_35
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DOI: https://doi.org/10.1007/978-3-7091-3396-5_35
Publisher Name: Springer, Vienna
Print ISBN: 978-3-211-82197-8
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