Somatostatin-like immunoreactivity and neurotransmitter metabolites in the cerebrospinal fluid of patients with senile dementia of Alzheimer type and Parkinson’s disease
The concentration of somatostatin-like immunoreactivity (SLI), the molecular forms of SLI, serotonin and dopamine metabolites in cerebrospinal fluid of patients with senile dementia of Alzheimer type (SDAT), Parkinson’s disease (PD) and age-matched control patients were determined by reverse phase HPLC and by specific radioimmunoassay. The mean SLI level in the control group was 29.5 ± 8.9 fmol/ml. In SDAT and PD the mean SLI level was significantly lower (18.6 7.9 fmol/ml, 21.4 ± 8.1 fmoI/ml). HPLC separation of SLI yielded four peaks with a preponderance of Somatostatin-14 (SST-14) and Somatostatin-28 (SST-28). In SDAT and PD changes in the molecular pattern of somatostatin indicate an altered biosynthesis and/or processing of somatostatin.
KeywordsAlzheimer Type Senile Dementia Dopamine Metabolite Global Deterioration Scale Neurotransmitter Metabolite
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