Summary
Biogenic amines and their metabolites in lumbar CSF and serum from 43 patients did not significantly differ between dementia of Alzheimer’s type (DAT), Binswanger’s disease (BD), multiinfarct dementia (MID) and Parkinson’s disease (PD). The only significant finding was elevated CSF 5-hydroxyindoleacetic acid (5HIAA) in DAT patients treated with neuroleptics relative to the other groups. The values found in a small number of patients with Pick’s, Huntington’s (CH) and Creutzfeldt-Jacob’s (CJ) disease were within the range of the other groups. CSF lactate, measured in 28 of the patients, tended to be elevated in vascular dementia (BD, MID). A crude estimate of cognitive impairment showed correlations to inner and outer brain atrophy in CT-scans. There were, however, no definite correlations between clinical impairments and CSF or serum findings.
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© 1990 Springer-Verlag Wien
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Sofic, E., Fritze, J., Schnaberth, G., Bruck, J., Riederer, P. (1990). Neurodegenerative diseases: CSF amines, lactate and clinical findings. In: Maurer, K., Riederer, P., Beckmann, H. (eds) Alzheimer’s Disease. Epidemiology, Neuropathology, Neurochemistry, and Clinics. Key Topics in Brain Research. Springer, Vienna. https://doi.org/10.1007/978-3-7091-3396-5_34
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DOI: https://doi.org/10.1007/978-3-7091-3396-5_34
Publisher Name: Springer, Vienna
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