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Memory loss by glutamate antagonists: an animal model of Alzheimer’s disease?

  • W. J. Schmidt
Part of the Key Topics in Brain Research book series (KEYTOPICS)

Summary

Spatial learning of rats was tested in T- and 8-arm radial mazes. MK-801 (0.16 and 0.33 mg/kg i.p.) that blocks glutamatergic transmission at the NMDA receptor, caused deficits in short-term memory and induced a strong tendency for perseveration. These symptoms are reminiscent of some clinical features of Alzheimer’s disease. In connection with anatomical, neurochemical and electrophysiological data, a glutamatergic deficit may tentatively be assumed to be implicated in this disease.

Keywords

NMDA Receptor Glutamatergic Transmission Perforant Pathway Glutamate Antagonist Spatial Reversal 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer-Verlag Wien 1990

Authors and Affiliations

  • W. J. Schmidt
    • 1
  1. 1.Zoologisches Institut, Abteilung NeuropharmakologieUniversity of TübingenFederal Republic of Germany

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