Memory loss by glutamate antagonists: an animal model of Alzheimer’s disease?

  • W. J. Schmidt
Part of the Key Topics in Brain Research book series (KEYTOPICS)


Spatial learning of rats was tested in T- and 8-arm radial mazes. MK-801 (0.16 and 0.33 mg/kg i.p.) that blocks glutamatergic transmission at the NMDA receptor, caused deficits in short-term memory and induced a strong tendency for perseveration. These symptoms are reminiscent of some clinical features of Alzheimer’s disease. In connection with anatomical, neurochemical and electrophysiological data, a glutamatergic deficit may tentatively be assumed to be implicated in this disease.


NMDA Receptor Glutamatergic Transmission Perforant Pathway Glutamate Antagonist Spatial Reversal 
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  1. Bischoff C, Tiedtke PI, Schmidt W J (1988) Learning in an 8-arm-radial maze: effects of dopamine-and NMDA-receptor-antagonists. In: Elsner N, Barth FG (eds) Sense organs — Interfaces between environment and behaviour. Proceedings of the 16th Göttingen Neurobiology Conference. G Thieme, Stuttgart New York, p 358Google Scholar
  2. Deutsch SI, Morihisa JM (1988) Giutamatergic abnormalities in Alzheimer’s disease and a rationale for clinical trials with L-glutamate. Clin Neuropharmacol 11: 18–35PubMedCrossRefGoogle Scholar
  3. Gustafsson B, Wigström H (1988) Physiological mechanisms underlying longterm potentiation. TINS 11: 156–162PubMedGoogle Scholar
  4. Hyman BT, VanHoesen GW, Kromer LJ, Damasio AR (1986) Perforant pathway changes and the memory impairment of Alzheimer’s disease. Ann Rev Neurol 20: 472 — 481Google Scholar
  5. Pearson RCA, Esiri MM, Hiorns RW, Wilcock GK, Powell TPS (1985) Anatomical correlates of the distribution of the pathological changes in the neocortex in Alzheimer disease. Proc Natl Acad Sci USA 82: 4531–4534PubMedCrossRefGoogle Scholar
  6. Procter AW, Palmer AM, Stratmann GC, Bowen DM (1986) Glutamate/aspartate-releasing neurons in Alzheimer’s disease [Letter]. N Engl J Med 314: 1711–1712PubMedGoogle Scholar

Copyright information

© Springer-Verlag Wien 1990

Authors and Affiliations

  • W. J. Schmidt
    • 1
  1. 1.Zoologisches Institut, Abteilung NeuropharmakologieUniversity of TübingenFederal Republic of Germany

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