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Characteristics of learning deficit induced by ibotenic acid lesion of the frontal cortex in rats

  • C. Hara
  • N. Ogawa
  • A. Mitani
  • S. Masuda
  • K. Kataoka
Part of the Key Topics in Brain Research book series (KEYTOPICS)

Summary

The present study examined influences of ibotenic acid lesions of the dorsolateral frontal cortex (DFC) and medial prefrontal cortex (MPC) having cholinergic input from the nucleus basalis of Meynert (NBM) on retention of discrimination avoidance learning in rats. The DFC and MPC lesions impaired the retention similar to the NBM lesion. In contrast to the NBM lesion, the DFC and MPC lesions reduced GAD activity, but not ChAT, in the cortex. Therefore, memory dysfunction based on the nerve cell loss of the frontal cortex may be involved in the GABAergic neuronal system.

Keywords

Medial Prefrontal Cortex Memory Dysfunction ChAT Activity Ibotenic Acid Ibotenic Acid Lesion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Wien 1990

Authors and Affiliations

  • C. Hara
    • 1
  • N. Ogawa
    • 1
  • A. Mitani
    • 2
  • S. Masuda
    • 2
  • K. Kataoka
    • 2
  1. 1.Department of PharmacologyEhime University School of MedicineEhime-kenJapan
  2. 2.First Department of PhysiologyEhime University School of MedicineEhime-kenJapan

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