Alzheimer-like changes of cortical amino acid transmitters in elderly Down’s syndrome
The concentrations of glutamate and GABA were determined in samples of frontal and temporal cortex and hippocampus taken post mortem from nine patients with Down’s syndrome and nine control subjects. These results were correlated with neuropathological findings and compared to changes found in patients with Alzheimer’s disease. GABA demonstrated an Alzheimer-like reduction in the temporal cortex and hippocampus, although this was not found in the frontal cortex. These deficits correlated with cell density but not plaque or tangle counts. Glutamate was significantly reduced only in the hippocampus, but found not to be changed in Alzheimer’s disease.
KeywordsTemporal Cortex Neurofibrillary Tangle Glutamate Concentration Amino Acid Transmitter Hippocampal Glutamate
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