Postreceptorial enhancement of neurotransmission for the treatment of cognitive disorders

  • H. Wachtel
  • R. Horowski
  • P. A. Löschmann
Part of the Key Topics in Brain Research book series (KEYTOPICS)


Based on the assumption that the impairment of cognitive functions in normal ageing, depression in the elderly, Morbus Parkinson or Morbus Alzheimer reflects the gradually different injury of the signal propagation in circumscribed neuronal systems due to degenerative and functional deficiencies, it is proposed to strengthen the signalling function of the remaining intact neurons in neurodegenerative disorders via manipulation of the intraneuronal availability of second messengers. This is illustrated for the noradrenergic system where the therapeutic usefulness of selective neuronal cyclic AMP phosphodiesterase inhibitors like rolipram or denbufylline appears particularly promising.


Adenylate Cyclase Locus Coeruleus Locus Coeruleus Neuron Messenger cAMP Presynaptic Component 
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Copyright information

© Springer-Verlag Wien 1990

Authors and Affiliations

  • H. Wachtel
    • 1
  • R. Horowski
    • 1
  • P. A. Löschmann
    • 1
  1. 1.Research Laboratories of Schering AGBerlin and BergkamenFederal Republic of Germany

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