Tyrosine hydroxylase, tryptophan hydroxylase, biopterin and neopterin in the brains and biopterin and neopterin in sera from patients with Alzheimer’s disease

  • T. Nagatsu
  • M. Sawada
  • M. Hagihara
  • N. Iwata
  • H. Arai
  • R. Iizuka
Part of the Key Topics in Brain Research book series (KEYTOPICS)


The activities of tyrosine hydroxylase (TH), tryptophan hydroxylase (TPH), and the concentrations of biopterin (BP) and neopterin (NP) were examined in postmortem brains from histologically verified patients of senile dementia of Alzheimer type (SDAT). The results suggest that the reductions in TH, TPH, and BP may be related to the reduction in monoamine neurotransmitters, due to destruction of monoaminergic neurons in SDAT, and may be an event independent of the cholinergic dysfunction. Serum BP levels were also significantly reduced in patients with SDAT.


Tyrosine Hydroxylase Locus Coeruleus Senile Dementia Tryptophan Hydroxylase Cholinergic Dysfunction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Wien 1990

Authors and Affiliations

  • T. Nagatsu
    • 1
  • M. Sawada
    • 2
  • M. Hagihara
    • 1
  • N. Iwata
    • 1
  • H. Arai
    • 3
  • R. Iizuka
    • 3
  1. 1.Department of BiochemistryNagoya University School of MedicineNagoyaJapan
  2. 2.Institute of Comprehensive Medical ScienceFujita Health UniversityToyoakeJapan
  3. 3.Department of Psychiatry, School of MedicineJuntendo UniversityTokyoJapan

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