Tyrosine hydroxylase, tryptophan hydroxylase, biopterin and neopterin in the brains and biopterin and neopterin in sera from patients with Alzheimer’s disease
The activities of tyrosine hydroxylase (TH), tryptophan hydroxylase (TPH), and the concentrations of biopterin (BP) and neopterin (NP) were examined in postmortem brains from histologically verified patients of senile dementia of Alzheimer type (SDAT). The results suggest that the reductions in TH, TPH, and BP may be related to the reduction in monoamine neurotransmitters, due to destruction of monoaminergic neurons in SDAT, and may be an event independent of the cholinergic dysfunction. Serum BP levels were also significantly reduced in patients with SDAT.
KeywordsTyrosine Hydroxylase Locus Coeruleus Senile Dementia Tryptophan Hydroxylase Cholinergic Dysfunction
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