Alterations in catecholamine neurons in the locus coeruleus in dementias of Alzheimer’s and Parkinson’s disease

  • V. Chan-Palay
  • E. Asan
Part of the Key Topics in Brain Research book series (KEYTOPICS)


A differentiation can be made between the LC in normal brain, in SDAT and PD for diagnostic purposes, based on the findings concerning the morphological alterations of the TH-immunoreactive neurons, the topographical distribution of neuron loss within the length of the LC, and, to some extent, the total reduction in cell number.


Locus Coeruleus Neuritic Plaque Rostral Part Locus Coeruleus Neuron Neuron Classis 


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  1. Chan-Palay V, Asan E (1989a) Quantitation of catecholamine neurons in the locus coeruleus in human brains of young and older adults. J Comp Neurol 287: 357–372CrossRefGoogle Scholar
  2. Chan-Palay V, Asan E (1989b) Alterations in catecholamine neurons of the locus coeruleus in senile dementia of the Alzheimer’s type, and in Parkinson’s disease with and without dementia. J Comp Neurol 287: 373–392CrossRefGoogle Scholar
  3. Chan-Palay V, Jentsch B, Lang W, Höchli M, Asan E (1990) Distribution of neuropeptide Y, C-terminal flanking peptide of NPY and Galanin and coexistence with catecholamine in the locus coeruleus of normal human, Alzheimer’s dementia and Parkinson’s disease brains. Dementia 1: 18–31Google Scholar

Copyright information

© Springer-Verlag Wien 1990

Authors and Affiliations

  • V. Chan-Palay
    • 2
  • E. Asan
    • 1
  1. 1.Neurology ClinicUniversity HospitalZürichSwitzerland
  2. 2.Neurology ClinicUniversity HospitalZürichSwitzerland

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