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Hippocampal and cardiovascular effects of muscarinic agents

  • J. Loudon
  • F. Brown
  • M. Clark
  • G. Riley
Part of the Key Topics in Brain Research book series (KEYTOPICS)

Summary

Muscarinic full and partial agonists were compared in rats for induction of hippocampal EEG effects (RSA) and falls in blood pressure and heart rate. Full agonists induced strong RSA and strong, higher potency, cardiovascular (CVS) effects. Partial agonists induced weak RSA and weaker, lower potency, CVS effects. RSA involves the septo-hippocampal cholinergic system which degenerates in dementia. It is inferred that partial agonists will cause weaker anti-dementia effects but less undesirable side effects than full agonists.

Keywords

Partial Agonist Theta Rhythm Full Agonist Muscarinic Agonist Muscarinic Agent 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Bevan P (1984) Effect of muscarinic agents on the electrical activity recordedfrom the hippocampus: a quantitative approach. Br J Pharmacol 82: 431–440PubMedCrossRefGoogle Scholar
  2. Bland BH (1986) The physiology and pharmacology of hippocampal formation theta rhythms. Prog Neurobiol 26: 1–54PubMedCrossRefGoogle Scholar
  3. Brown F, Clark M, Graves D, Hadley M, Hatcher J, McArthur R, Riley G, Semple J (1988) Variation of muscarinic activities of oxotremorine analogues. Drug Dev Res 14: 343–347CrossRefGoogle Scholar
  4. Clark MSG, Hatcher J, Brown F (1989) Relative aversive potency of muscarinic agonists. TIPS [Suppl 4]: 100Google Scholar
  5. Wettstein A, Spiegel R (1984) Clinical trials with the cholinergic drug RS 86 in Alzheimer’s disease (AD) and senile dementia of the Alzheimer type (SDAT). Psychopharmacology 84: 572–573PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Wien 1990

Authors and Affiliations

  • J. Loudon
    • 1
  • F. Brown
    • 1
  • M. Clark
    • 1
  • G. Riley
    • 1
  1. 1.Beecham Pharmaceuticals Research DivisionHarlow, EssexUK

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