Hippocampal and cardiovascular effects of muscarinic agents
Muscarinic full and partial agonists were compared in rats for induction of hippocampal EEG effects (RSA) and falls in blood pressure and heart rate. Full agonists induced strong RSA and strong, higher potency, cardiovascular (CVS) effects. Partial agonists induced weak RSA and weaker, lower potency, CVS effects. RSA involves the septo-hippocampal cholinergic system which degenerates in dementia. It is inferred that partial agonists will cause weaker anti-dementia effects but less undesirable side effects than full agonists.
KeywordsPartial Agonist Theta Rhythm Full Agonist Muscarinic Agonist Muscarinic Agent
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