Acetylcholine synthesis and membrane phospholipids

  • K. J. Martin
  • L. Widdowson
Part of the Key Topics in Brain Research book series (KEYTOPICS)


The effect of chronic treatment with pyritinol on the phospholipid composition of synaptosomal membranes has been examined in rats. The treatment does not significantly change phospholipid content of synaptosomal membranes obtained from the cortex of young rats; in old rats an increase in total phospholipid content and phosphatidylcholine was observed. The results suggest that the pyritinol induced increase in cerebral ACH levels does not occur at the expense of membrane phospholipids.


Phospholipid Content Corpus Striatum Synaptosomal Membrane Acetylcholine Synthesis Synaptosomal Plasma Membrane 
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  1. Blusztajn JK, Liscovitch M, Richardson UI (1987) Synthesis of acetylcholine from choline derived from phosphatidylcholine in a human neuronal cell line. Proc Natl Acad Sci 84: 5474–5477PubMedCrossRefGoogle Scholar
  2. Breckenridge WC, Gombos G, Morgan IG (1972) The lipid composition of adult rat brain synaptosomal plasma membranes. Biochim Biophys Acta 266: 605–707CrossRefGoogle Scholar
  3. Gray EG, Whittaker VP (1962) The isolation of nerve endings from brain. An electron-microscopic study of cell fragments divided by homogenisation and centrifugation. J Anat (London) 96: 79–88Google Scholar
  4. Martin KJ, Vyas S (1987) Increase in acetylcholine concentrations in the brain of ‘old’ rats following treatment with pyrithioxin ( Encephabol ). Br J Pharmacol 90: 561–565Google Scholar
  5. Stein J, Smith G (1982) Techniques in the life sciences. Biochemistry — B4/1. Elsevier BiomedicalGoogle Scholar
  6. Ulus IH, Wurtman RJ, Mauron C, Blusztajn JK (1989) Choline increases acetylcholine release and protects against the stimulation-induced decrease in phophatide levels within membranes of rat corpus striatum. Brain Res 484: 217–227PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Wien 1990

Authors and Affiliations

  • K. J. Martin
    • 1
  • L. Widdowson
    • 1
  1. 1.Department of PharmacologyUniversity of CambridgeCambridgeUK

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