Acetylcholine synthesis and membrane phospholipids
The effect of chronic treatment with pyritinol on the phospholipid composition of synaptosomal membranes has been examined in rats. The treatment does not significantly change phospholipid content of synaptosomal membranes obtained from the cortex of young rats; in old rats an increase in total phospholipid content and phosphatidylcholine was observed. The results suggest that the pyritinol induced increase in cerebral ACH levels does not occur at the expense of membrane phospholipids.
KeywordsPhospholipid Content Corpus Striatum Synaptosomal Membrane Acetylcholine Synthesis Synaptosomal Plasma Membrane
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