Impairment of cerebral glucose metabolism parallels learning and memory dysfunctions after intracerebral streptozotocin
In early-onset Alzheimer’s disease, the cerebral glucose metabolism is disturbed in a characteristic manner. Here, we attempted to mimick these alterations by intracerebral injection of the pancreatic islet cell toxin streptozotocin (STZ) into the rat brain ventricles. This treatment resulted in a reduced arteriovenous difference (AVD) of glucose, an increased AVD of lactate, whereas the AVDs of oxygen and carbon dioxide remained unchanged. In addition, learning and memory functions were impaired. These alterations may be related to a disturbance of the local action of insulin on the brain. Furthermore, the approach reported here may provide a model for the study of the early pathogenetic events of Alzheimer’s disease.
KeywordsCerebral Glucose Metabolism Passive Avoidance Test Pancreatic Endocrine Cell Sensory Attention Cognitive Attention
Unable to display preview. Download preview PDF.
- Pellegrino DA, Miletich DJ, Albrecht RF (1987) Effects of superfused insulin on cerebral cortical glucose utilization in awake goats. Am J Physiol 253 (Endocrinol Metab 16): E418 - E427Google Scholar
- Yorek MA, Dunlap JA, Ginsberg BH (1987) Amino acid and putative neurotransmitter transport in human Y79 retinoblastoma cells. J Biol Chem 262: 10968–10993Google Scholar