Lactate production and glycolytic enzymes in sporadic and familial Alzheimer’s disease
In this paper we report the results of an investigation of lactate production and of the activity of phosphofructokinase (PFK), lactate dehydrogenase (LDH) and hexokinase (HK) in skin cultured fibroblasts from familial and sporadic Alzheimer’s disease patients. We found that the activity of HK was deficient in some patients with the familial dominant form of Alzheimer’s disease. These results indicate that some alterations on the energy metabolism are present in some subjects with the familial Alzheimer’s disease but not in sporadic cases.
KeywordsLactate Production Glycolytic Enzyme Unaffected Relative Cerebral Glucose Utilization Pyruvate Dehydrogenase Complex Activity
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- Lowrey OH, Passaneau J (1964) The relation between substrates and enzymes of glycolysis in brain. J Biol Chem 139: 31–38Google Scholar
- Sokoloff L (1966) Cerebral circulatory and metabolic changes associated with aging. Res Publ Assoc Res Nery Ment Dis 41: 237–241Google Scholar
- Sorbi S, Blass JP (1983) Fibroblast phosphofructokinase in Alzheimer’s disease and Down’s syndrome. Banbury Rep 15: 297–307Google Scholar