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Lactate production and glycolytic enzymes in sporadic and familial Alzheimer’s disease

  • S. Sorbi
  • M. Mortilla
  • S. Piacentini
  • G. Tesco
  • S. Latorraca
  • B. Nacmias
  • S. Tonini
  • L. Amaducci
Part of the Key Topics in Brain Research book series (KEYTOPICS)

Summary

In this paper we report the results of an investigation of lactate production and of the activity of phosphofructokinase (PFK), lactate dehydrogenase (LDH) and hexokinase (HK) in skin cultured fibroblasts from familial and sporadic Alzheimer’s disease patients. We found that the activity of HK was deficient in some patients with the familial dominant form of Alzheimer’s disease. These results indicate that some alterations on the energy metabolism are present in some subjects with the familial Alzheimer’s disease but not in sporadic cases.

Keywords

Lactate Production Glycolytic Enzyme Unaffected Relative Cerebral Glucose Utilization Pyruvate Dehydrogenase Complex Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Wien 1990

Authors and Affiliations

  • S. Sorbi
    • 1
  • M. Mortilla
    • 1
  • S. Piacentini
    • 1
  • G. Tesco
    • 1
  • S. Latorraca
    • 1
  • B. Nacmias
    • 1
  • S. Tonini
    • 1
  • L. Amaducci
    • 1
  1. 1.Department of Neurology and PsychiatryUniversity of FlorenceFlorenceItaly

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